Cyclophanes. VIII. Synthesis and DNA-cleaving activities of novel heterocyclophanes containing two 4,4'-bithiazole rings

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 1, 1997, Pages 189-193

  Sasaki, Hideaki ^a   Suehiro, Atsumi ^a   Nakamoto, Yasuyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

4,4' bithiazole; cobalt complex; cyclophane; DNA cleavage; heterocyclophane; polyamine

Indexed keywords

3,6,21,24 TETRAAZA[8.8](2,2')(4,4' BITHIAZOLOPHANE); 3,7,22,26 TETRAAZA[9.9](2,2')(4,4' BITHIAZOLOPHANE); ALKYLATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CYCLIZATION; DNA CLEAVAGE; DRUG CONFORMATION; DRUG DNA BINDING; DRUG SYNTHESIS; METAL BINDING; NONHUMAN; PLASMID; STRUCTURE ACTIVITY RELATION;

EID: 0031013019     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.189     Document Type: Article

References (18)

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11. Concerning thiazole-containing heterocyclophanes, two research groups have reported the synthesis and the conformational properties of [2.2](2,5)thiazolophane and the synthesis and the metal-binding abilities of macrocycles having one or more 2,2′-bithiazole rings. See: Mashraqui S. H., Keehn P. M., J. Am. Chem. Soc., 104, 4461-4465 (1982); Lehn J-M., Regnouf de Vains J-B., Helv. Chim. Acta, 75, 1221-1236 (1992) ; Lehn J-M., Regnouf de Vains J-B., Tetrahedron Lett., 30, 2209-2212 (1989).
12. Concerning thiazole-containing heterocyclophanes, two research groups have reported the synthesis and the conformational properties of [2.2](2,5)thiazolophane and the synthesis and the metal-binding abilities of macrocycles having one or more 2,2′-bithiazole rings. See: Mashraqui S. H., Keehn P. M., J. Am. Chem. Soc., 104, 4461-4465 (1982); Lehn J-M., Regnouf de Vains J-B., Helv. Chim. Acta, 75, 1221-1236 (1992) ; Lehn J-M., Regnouf de Vains J-B., Tetrahedron Lett., 30, 2209-2212 (1989).
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