Amylin and food intake in mice: Effects on motivation to eat and mechanism of action

Pharmacology Biochemistry and Behavior

Volumn 56, Issue 1, 1996, Pages 123-129

  Morley, John E ^a,b,c   Suarez, Michael D ^a,b   Mattamal, Michael ^a,b   Flood, James F ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c School of Medicine (M239)   (United States)

Author keywords

amylin; anorexia; appetite; food intake; L arginine; lever press; motivation; nitric oxide; nitric oxide synthase

Indexed keywords

AMYLIN; ARGININE; LITHIUM CHLORIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APPETITE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; MALE; MOTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH FUNDUS; TASTE AVERSION;

AMYLOID; ANIMALS; APPETITE DEPRESSANTS; ARGININE; AVOIDANCE LEARNING; CONDITIONING, OPERANT; DRINKING; EATING; GASTRIC FUNDUS; MALE; MICE; MICE, INBRED STRAINS; MILK; MOTIVATION; NITRIC OXIDE SYNTHASE; TASTE; WATER;

EID: 0031012556     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00168-2     Document Type: Article

References (31)

1. Balasurbamaniam A., Renugopalakrishnan V., Stein M., Fischer J. E., Chance W. T. Synthesis, structures and anorectic effects of human and rat amylin. Peptides. 12:1991;919-924.
2. Billington C. J., Levine A. S., Morley J. E. Are peptides truly satiety agents? A method of testing for neurohumoral satiety effects. Am. J. Physiol. 245:1983;R920-R929.
3. Bradford M. A. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
4. Calignano A., Persico P., Mancuso F., Sorrrentino L. Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice. Eur. J. Pharmacol. 231:1993;415-419.
5. Carey R. J. Acquired aversion to amphetamine solutions. Pharmacol. Biochem. Behav. 1:1973;227-229.
6. Chance W. T., Balasurbamaniam A., Zhang F. S., Wimalawansa S. J., Fischer J. E. Anorexia following the intrahypothalamic administration of amylin. Brain Res. 539:1991;352-356.
7. Chance W. T., Balasurbamaniam A., Chen X., Fischer J. E. Tests of adipsia and conditioned taste aversion following the intrahypothalamic injection of amylin. Peptides. 13:1992;961-964.
8. Chance W. T., Balasurbamaniam A., Stallion A., Fischer J. E. Anorexia following the systemic injection of amylin. Brain Res. 607:1993;185-188.
9. Davis J. L., Buresova O., Bures J. Cortical spreading depression and conditioned taste aversion. An attempt to resolve a controversy Behav. Neural. Biol. 19:1977;55-63.
10. Desai K. M., Zembowicz A., Sessa W. C., Vane J. R. Nitroxergic nerves mediate vagally induced relation of the isolated stomach of guinea pig. Proc. Natl. Acad. Sci. U.S.A. 88:1991;11490-11494.
11. Deutsch J. A., Hardy W. T. Cholecystokinin produces bait shyness in rats. Nature. 266:1977;196.
12. Edwards B. J., Morley J. E. Amylin. Life Sci. 51:1992;1899-1912.
13. Flood J. F., Silver A. J., Morley J. E. Does peptide-induced changes in feeding occur because of changes in motivation to eat? Peptides. 11:1990;265-270.
14. Flood J. F., Hernandez E. N., Morely J. E. Modulation of memory processing by neuropeptide Y. Brain Res. 421:1987;280-290.
15. Gibbs J., Fauser D. J., Rowe E. A., Rolls E. T., Maddison S. P. Bombesin suppresses feeding in rats. Nature. 282:1979;208-210.
16. Keppel G. Design and analysis. A researcher's handbook:1973;Prentice-Hall, Englewood Cliffs, NJ.
17. Krahn D. D., Gosnell B.A., Levine A. S., Morley J. E. Effects of calcitonin gene-related peptide on food intake. Peptides. 5:1984;861-864.
18. Le Sauter J., Geary N. Pancreatic glucagon and cholecystoinin synergistically inhibit sham feeding in rats. Am. J. Physiol. 253:1987;R719-R725.
19. Moncado S. The L-arginine nitric oxide pathway. Acta Physiologcia Scandinavia. 145:1992;201-227.
20. Morley J. E. Neuropeptide regulation of appetitive and weight. Endocrine Rev. 8:1987;256-287.
21. Morley J. E. Appetite regulation by gut peptides. Ann. Rev. Nutr. 10:1990;383-386.
22. Morley J. E., Flood J. F. Amylin decreases food intake in mice. Peptides. 12:1991;865-869.
23. Morley J. E., Flood J. F. Evidence that nitric oxide modulates food intake in mice. Life Sci. 49:1991;707-711.
24. Morley J. E., Flood J. F. Competitive antagonism of nitric oxide synthetase causes weight loss in mice. Life Sci. 51:1992;1285-1289.
25. Morley J. E., Morley P. M. K., Flood J. F. Anorectic effects of amylin in rats over the life span. Pharmacol. Biochem. Behav. 44:1993;577-580.
26. Morley J. E., Flood J. F., Horowitz M., Morley P. M. K., Walter M. J. Modulation of food intake by peripherally administered amylin. Am. J. Physiol. 267:1994;R178-84.
27. Morley J. E., Levine A. S., Kneep J., Grace M., Billington C. J. The effect of peripherally administered satiety substances on feeding induced by butorphanol tartrate. Pharmacol. Biochem. Behav. 19:1983;577-582.
28. Nachman M., Ashe J. H. Learned taste aversions in rats as a function of dosage, concentration and route of administration of LiCl. Physiol. Behav. 10:1973;73-78.
29. Smith G. P., Gibbs J. Gut peptides and post prandial satiety. Fed. Proc. 43:1984;2889-2892.
30. Squadrito F., Calapai G., Altavilla D., Cucinotta D., Zingarelli B., Campo G. M., Arcoraci V., Sautebin L., Mazzaglia G., Caputi A. P. Food deprivation increases brain nitric oxide synthase and depresses brain serotonin levels in rats. Neuropharmacology. 33:1994;83-86.
31. Winer B. J Statistical principles in experimental design. 2:1971;McGraw-Hill, New York.