Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 1, 1997, Pages 187-192

  Papageorgiou, Christos ^a   Kallen, Jörg ^a   France, Julien ^a   French, Richard ^a,b  

^a Sandoz Pharma Ltd   (Switzerland)

^b Inst fur Org Chem der Univ B   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOPHILIN A; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; PHOSPHATASE;

ALKYLATION; BINDING AFFINITY; CONFERENCE PAPER; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MIXED LYMPHOCYTE REACTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY;

CYCLOSPORINE; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; VALINE;

EID: 0031012454     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00204-0     Document Type: Conference Paper

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