The total synthesis of UK-1

Tetrahedron Letters

Volumn 38, Issue 2, 1997, Pages 199-202

  DeLuca, Mark R ^a   Kerwin, Sean M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (2 HYDROXYPHENOL)BENZOXAZOL 4 YL] 4 BENZOXAZOLE CARBOXYLIC ACID; BENZOXAZOLE DERIVATIVE; UK 1; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

EID: 0031012286     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02288-5     Document Type: Article

References (11)

1. Ueki, M.; Ueno, K.; Miyadoh, S.; Abe, K.; Shibata, K.; Taniguchi, M.; Oi, S. J. Antibiotics 1993, 46, 1089-1094.
2. Shibata, K.; Kashiwada, M.; Ueki, M.; Taniguchi, M. J. Antibiotics 1993, 46, 1095-1100.
3. Previously reported synthetic, cytotoxic bis(benzoxazoles) have the 2-position of one benzoxazole ring joined to the 5-position of the second ring: Bathini, Y.; Rao, K.E.; Shea, R.G.; Lown, J.W. Chem. Res. Toxicol. 1990, 3, 268-280.
4. 4: 270.0766, found 270.0767.
5. Goldstein, S.W.; Dambek, P.J. J. Heterocyclic Chem. 1990, 27, 335-336.
6. 6: 495.1556, found 495.1547.
7. 2. Me-UK-1 was prepared in a similar manner (32 mg, 96%).
8. Frakas, L; Vermes, B.; Nogradi, M. Tetrahedron 1967, 23, 741-744.
9. Dunwell, D.W.; Evans, D.; Hicks, T.A.; Cashin, C.H.; Kitchen, A. J. Med. Chem. 1975, 18, 53-58.
10. 4: 346.1079, found 346.1076.
11. We gratefully acknowledge research support from the US Public Health Service Grant GM-50892.