Uptake and salvage of hypoxanthine mediates developmental arrest in preimplantation mouse embryos

Biology of Reproduction

Volumn 56, Issue 1, 1997, Pages 1-13

  Dienhart, Mary K ^a   O'Brien, Marilyn J ^b   Downs, Stephen M ^a  

^a MARQUETTE UNIVERSITY   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; BLASTOCYST; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; GENE TRANSFER; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; MOUSE; NONHUMAN; OOCYTE CLEAVAGE; PENTOSE PHOSPHATE CYCLE; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL;

1-METHYL-3-ISOBUTYLXANTHINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLASTOCYST; CELL COUNT; CULTURE TECHNIQUES; EMBRYO; EMBRYO TRANSFER; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC DEVELOPMENT; FEMALE; GLUCOSE; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MORULA; PREGNANCY; ZYGOTE;

EID: 0031012099     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod56.1.1     Document Type: Article

References (70)

1. Kelley WN. Purine and pyrimidine metabolism. In: Rothblatt GH, Cristofalo VJ (eds.), Growth, Nutrition, and Metabolism of Cells in Culture, 1. New York and London: Academic Press; 1972: 211-256.
2. Brinster RL. Nutrition and metabolism of the ovum, zygote, and blastocyst. In: Greep RO, Astwood EB (eds.), Handbook of Physiology, Section 7, Volume II, Part 2. Washington, DC: American Physiological Society; 973: 165-185.
3. Mintz B. Synthetic processes and early development in the mammalian egg. J Exp Zool 1964; 157:85-100.
4. Monesi V, Salfi V. Macromolecular synthesis during early development in the mouse embryo. Exp Cell Res 1967; 46:632-635.
5. Epstein CJ, Daentl DL. Precursor pools and RNA synthesis in preimplantation mouse embryos. Dev Biol 1971; 26:517-524.
6. Clegg KB, Piko L. RNA synthesis and cytoplasmic polyadenylation in the one-cell mouse embryo. Nature 1982; 295:342-345.
7. Thomson TenBroeck J. Effects of nucleosides and nucleoside bases on the development of preimplantation mouse embryos in vitro. J Reprod Fertil 1968; 17:571-573.
8. Loutradis D, John D, Kiessling AA. Hypoxanthine causes a 2-cell block in random-bred mouse embryos. Biol Reprod 1987; 37:311-316.
9. Nureddin A, Epsaro E, Kiessling AA. Purines inhibit the development of mouse embryos in vitro. J Reprod Fertil 1990; 90:455-464.
10. Alexiou M, Leese HJ. Purine utilisation, de novo synthesis and degradation in mouse preimplantation embryos. Development 1992; 114: 185-192.
11. Downs SM, Dow MPD. Hypoxanthine-maintained two-cell block in mouse embryos: dependence on glucose and effect of hypoxanthine phosphoribosyltransferase inhibitors. Biol Reprod 1991; 44:1025-1039.
12. Nasr-Esfahani MM, Johnson MH. The origin of reactive oxygen species in mouse embryos cultured in vitro. Development 1991; 113:551-560.
13. Dienhart MK, Downs SM. Cyclic AMP reversal of hypoxanthine-arrested preimplantation mouse embryos is EDTA-dependent. Zygote 1996; (in press).
14. Bastias MC, McGee-Belser ST, Bryan SH, Vasquez JM. In vitro deleterious effect of hypoxanthine in Ham's Nutrient Mixture F-10 culture medium on human oocyte fertilization and early embryonic development. Fertil Steril 1993; 60:876-880.
15. Loutradis DC, Kiessling AA, Kallianidis K, Siskos K, Creatsas G, Michalas S, Aravantinos D. A preliminary trial of human zygote culture in Ham's F-10 without hypoxanthine. J Assist Reprod Genet 1993; 10:271-275.
16. Kane MT, Foote RH. Culture of two- and four-cell rabbit embryos to the expanding blastocyst stage in synthetic media. Proc Soc Exp Biol Med 1970; 133:921-925.
17. Fissore R, O'Keefe S, Kiessling AA. Purine-induced block to mouse embryo cleavage is reversed by compounds that elevate cyclic adenosine monophosphate. Biol Reprod 1992; 47:1105-1112.
18. Downs SM, Daniel SAJ, Bornslaeger EA, Hoppe PC, Eppig JJ. Maintenance of meiotic arrest in mouse oocytes by purines: modulation of cAMP levels and cAMP phosphodiesterase activity. Gamete Res 1989; 23:323-334.
19. Epstein CJ. Phosphoribosyltransferase activity during early mammalian development. J Biol Chem 1970; 245:3289-3294.
20. Kratzer PG. Expression of maternally and embryonically derived hypoxanthine phosphoribosyltransferase (HPRT) activity in mouse eggs and early embryos. Genetics 1983; 104:685-689.
21. Harper MI, Monk M. Evidence for translation of HPRT enzyme on maternal mRNA in early mouse embryos. J Embryol Exp Morphol 1983; 74:15-28.
22. Monk M. Biochemical microassays for X-chromosome-linked enzymes HPRT and PGK. In: Monk M (ed.), Mammalian Development: A Practical Approach. Oxford, Washington, DC: IRL Press; 1987: 140-161.
23. Alexiou M, Leese HJ. Enzymes of purine salvage and catabolism in the mouse preimplantalion embryo measured by high performance liquid chromatography. J Reprod Fertil 1994; 101:151-158.
24. Biggers JD, Whittingham DG, Donahue RP. The pattern of energy metabolism in the mouse oocyte and zygote. Proc Natl Acad Sci USA 1967; 58:560-567.
25. Brinster RL. Studies on the development of mouse embryos in vitro. IV. Interaction of energy sources. J Reprod Fertil 1965; 10:227-240.
26. Chatot CL, Ziomek CA, Bavister BD, Lewis JL, Torres I. An improved culture medium supports development of random-bred 1-cell mouse embryos in vitro. J Reprod Fertil 1989; 86:679-688.
27. Whitten WK. Culture of tubal ova. Nature 1957; 179:1081-1082.
28. Brinster RL, Thomson JL. Development of eight-cell mouse embryos in vitro. Exp Cell Res 1966; 42:308-315.
29. Brown JJG, Whittingham DG. The roles of pyruvate, lactate and glucose during preimplantation development of embryos from F1 hybrid mice in vitro. Development 1991; 112:99-105.
30. Chatot CL, Lewis-Williams J, Torres I, Ziomek CA. One-minute exposure of 4-cell mouse embryos to glucose overcomes the morula block in CZB medium. Mol Reprod Dev 1994; 37:407-412.
31. Nasr-Esfahani MH, Winston NJ, Johnson MH. Effects of glucose, glutamine, ethylenediaminetetraacetic acid and oxygen tension on the concentration of reactive oxygen species and on development of the mouse preimplantation embryo in vitro. J Reprod Fertil 1992; 96:219-231.
32. Martin KL, Leese HJ. Role of glucose in mouse preimplantation embryo development. Mol Reprod Dev 1995; 40:436-443.
33. Barbehenn EK, Wales RG, Lowry OH. The explanation for the blockade of glycolysis in early mouse embryos. PNAS 1974; 71:1056-1060.
34. Barbehenn EK, Wales RG, Lowry OH. Measurement of metabolites in single preimplantation embryos; a new means to study metabolic control in early embryos. J Embryol Exp Morphol 1978; 43:29-46.
35. Brinster RL. Hexokinase activity in the preimplantation mouse embryo. Enzymologia 1968; 34:304-308.
36. Gardner DK, Leese HJ. The role of glucose and pyruvate transport in regulating nutrient utilization by preimplantation mouse embryos. Development 1988; 104:423-429.
37. Leese HJ. Metabolism of the preimplantation mammalian embryo. In: Milligan SR (ed.), Oxford Reviews of Reproductive Biology, 13. London: Oxford University Press; 1991: 35-72.
38. Gardner HG, Kaye PL. Characterization of glucose transport in preimplantation mouse embryos. Reprod Fertil Dev 1995; 7:41-50.
39. O'Fallon JV, Wright RW. Quantitative determination of the pentose phosphate pathway in preimplantation mouse embryos. Biol Reprod 1986; 34:58-64.
40. Marz R, Wohlhueter RM, Plagemann PGW. Purine and pyrimidine transport and phosphoribosylation and their interaction in overall uptake by cultured mammalian cells. J Biol Chem 1979; 254:2329-2338.
41. Kuehn MR, Bradley A, Robertson EJ, Evans MJ. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 1987; 326:295-298.
42. Hoppe PC. Technique of fertilization in vitro. In: Dixon RL (ed.), Reproductive Toxicology. New York: Raven Press; 1985: 191-199.
43. Du ZF, Wales RG. Some effects of genotype and composition of the culture medium on the development of mouse zygotes in vitro. Reprod Fertil Dev 1993; 5:405-415.
44. King MT, Passonneau JV, Veech RL. Radiometric measurement of phosphoribosyl-pyrophosphate and ribose 5-phosphate by enzymatic procedures. Anal Biochem 1990; 187:179-186.
45. Brennan TJ, Ohkawa R, Gore SD, Behrman HR. Adenine-derived purines increase adenosine triphosphate (ATP) levels in the luteal cell: evidence that cell levels of ATP may limit the stimulation of adenosine 3′,5′-monophosphate accumulation by luteinizing hormone. Endocrinology 1982; 112:499-508.
46. Bolton VN, Oades PJ, Johnson MH. The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo. J Embryol Exp Morphol 1984; 79:139-163.
47. Leese HJ, Barton AM. Pyruvate and glucose uptake by mouse ova and preimplantation embryos. J Reprod Fertil 1984; 72:9-13.
48. Gardner DK, Leese HJ. Non-invasive measurement of nutrient uptake by single cultured pre-implantation mouse embryos. Hum Reprod 1986; 1:25-27.
49. Quinn P, Wales RG. Adenosine triphosphate content of preimplantation mouse embryos. J Reprod Fertil 1971; 25:133-135.
50. Quinn P, Wales RG. The effect of culture in vitro on the levels of adenosine triphosphate in preimplantation mouse embryos. J Reprod Fertil 1973; 32:231-241.
51. Ginsberg L, Hillman N. ATP metabolism in cleavage-staged mouse embryos. J Embryol Exp Morphol 1973; 30:267-282.
52. Leese HJ, Biggers JD, Mroz EA, Lechene C. Nucleotides in a single mammalian ovum or preimplantation embryo. Anal Biochem 1984; 140:443-448.
53. Pratt HPM. Isolation, culture and manipulation of preimplantation mouse embryos. In: Monk M (ed.), Mammalian Development: A Practical Approach. Oxford, Washington DC: IRL Press; 1987: 13-41.
54. Gordon RB, Thompson L, Johnson LA, Emmerson BT. Regulation of purine de novo synthesis in cultured human fibroblasts: the role of P-Ribose-PP. Biochim Biophys Acta 1979; 562:162-176.
55. Snyder FF, Henderson JF. Effects of actinomycin D on purine ribonucleotide metabolism in Ehrlich ascites tumor cells in vitro. Can J Biochem 1974; 52:263-267.
56. Bagnara AS, Letter AA, Henderson JF. Multiple mechanisms of regulation of purine biosynthesis de novo in intact tumor cells. Biochim Biophys Acta 1974; 374:259-270.
57. Taylor MW, Olivelle S, Levine RA, Coy K, Hershey H, Gupta KC, Zawistowich L. Regulation of de novo purine biosynthesis in chinese hamster cells. J Biol Chem 1982; 257:377-380.
58. Becker MA, Raivio KO, Seegmiller JE. Synthesis of phosphoribosylpyrophosphate in mammalian cells. Adv Enzymol 1979; 49:281-306.
59. Karl DM. Cellular nucleotide measurements and applications in microbial ecology. Microbiol Rev 1980; 44:739-796.
60. Latham KE, Garrels JI, Chang C, Solter D. Quantitative analysis of protein synthesis in mouse embryos. I. Extensive reprogramming at the one- and two-cell stages. Development 1991; 112:921-932.
61. Rieger D. Relationships between energy metabolism and development of early mammalian embryos. Theriogenology 1992; 37:75-93.
62. McCollister RJ, Gilbert WR, Ashton DM, Wyngaarden JB. Pseudo-feedback inhibition of purine synthesis by 6-mercaptopurine ribonucleotide and other purine analogues. J Biol Chem 1964; 239:1560-1563.
63. Bennett LL, Brockman RW, Schnebli HP, Chumley S, Dixon GJ, Schabel FM, Dulmadge EA, Skipper HE, Montgomery JA, Thomas HJ. Activity and mechanism of action of 6-methylthiopurine ribonucleoside in cancer cells resistant to 6-mercaptopurine. Nature 1965; 205:1276-1279.
64. Elion GB. The purine path to chemotherapy. Science 1989; 244:41-47.
65. Plagemann PGW, Wohlhueter RM. Inhibition of the transport of adenosine, other nucleosides and hypoxanthine in Novikoff rat hepatoma cells by methylxanthines, papaverine, N6-cyclohexyladenosine and N6-phenylisopropyladenosine. Biochem Pharmacol 1984; 33:1783-1788.
66. Chatot CL, Lewis JL, Torres I, Ziomek CA. Development of 1-cell embryos from different strains of mice in CZB medium. Biol Reprod 1990; 42:432-440.
67. Brown JJG, Whittingham DG. The dynamic provision of different energy substrates improves development of one-cell random-bred mouse embryos in vitro. J Reprod Fertil 1992; 95:503-511.
68. Lawitts JA, Biggers JD. Optimization of mouse embryo culture media using simplex methods. J Reprod Fertil 1991; 91:543-556.
69. Paynton BV, Rempel R, Bachvarova R. Changes in state of adenylation and time course of degradation of maternal mRNAs during oocyte maturation and early embryonic development in the mouse. Dev Biol 1988; 129:304-314.
70. Gardner DK, Sakkas D. Mouse embryo cleavage, metabolism and viability: role of medium composition. Hum Reprod 1993; 8:288-295.