Does antimitochondrial antibody status affect response to treatment in patients with primary biliary cirrhosis? Outcomes of ursodeoxycholic acid therapy and liver transplantation

Hepatology

Volumn 26, Issue 1, 1997, Pages 22-26

  Kim, W Ray ^a   Poterucha, John J ^a   Jorgensen, Roberta A ^a   Batts, Kenneth P ^a   Homburger, Henry A ^a   Dickson, E Rolland ^a   Krom, Ruud A F ^a   Wiesner, Russell H ^a   Lindor, Keith D ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRION ANTIBODY; URSODEOXYCHOLIC ACID;

ADULT; AGED; ANTIBODY RESPONSE; ARTICLE; CHOLESTASIS; FEMALE; HUMAN; IMMUNOFLUORESCENCE; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; QUALITY OF LIFE; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 0031011218     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260103     Document Type: Article

References (25)

1. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1987;316:521-528.
2. Poupon RE, Poupon R, Balkau B. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994;330:1342-1347.
3. Lindor KD, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Murtaugh PA, HarrisonJM, et al. Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994;106:1284-1290.
4. Heathcote EJ, Lindor KD, Poupon R, Cauch-Dubek K, Dickson ER, Trout R, Poupon RE. Combined analysis of French, American and Canadian randomized controlled trials of Ursodeoxycholic acid therapy in primary biliary cirrhosis [Abstract]. Gastroenterology 1995;108:A1082.
5. Markus BH, Dickson ER, Grambsch PM, Fleming TR, Mazzaferro V, Klintmalm GBG, Wiesner RH, et al. Efficacy of liver transplantation in patients with primary biliary cirrhosis. N Engl J Med 1989;320:1709-1713.
6. Starzl TE, Demetris AJ, Van Thiel DH. Liver transplantation. N Engl J Med 1989;321:1092-1099.
7. Michieletti P, Wanless IR, Katz A, Scheuer PJ, Yeaman SJ, Bassendine MF, Palmer JM, et al. Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis. Gut 1994;35:260-265.
8. Goodman ZD, McNally PR, Davis DR, Ishak KG. Autoimmune cholangitis: A variant of primary biliary cirrhosis. Clinicopathologic and serologic correlations in 200 cases. Dig Dis Sci 1995;40:1232-1242.
9. Lacerda MA, Ludwig J, Dickson Er, Jorgensen RA, Lindor KD. Antimitochondrial antibody-negative primary biliary cirrhosis. Am J Gastroenterol 1995;90:247-249.
10. Colombato LA, Alvarez F, Cote J, Huet PM. Autoimmune cholangiopathy: The result of consecutive primary biliary cirrhosis and autoimmune hepatitis? Gastroenterology 1994;107:1839-1843.
11. Ludwig J, Wiesner RH, LaRusso NF. Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis. J Hepatol 1988;7:193-199.
12. Balan V, Batts KP, Porayko MK, Krom RA, Ludwig J, Wiesner RH. Histological evidence for recurrence of primary biliary cirrhosis after liver transplantation. HEPATOLOGY 1993;18:1392-1398.
13. Sherlock S. Primary biliary cirrhosis: Clarifying the issues. Am J Med 1994;96:27-33.
14. Gershwin ME, MacKay IR, Sturgess A, Coppel RL. Identification and specificity of a cDNA encoding the 70kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 1987;138:3525-3531.
15. Van de Water J, Turchany J, Leung PSC, Lake J, Munoz S, Surh CD, Coppel R, et al. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest 1993;91:2653-2664.
16. Krams SM, Surh CD, Coppel RL. Immunization of experimental animals with dihydrolipoamide acetyltransferase, a purified recombinant polypeptide, generates mitochondrial autoantibodies but not primary biliary cirrhosis. HEPATOLOGY 1989;9:411-416.
17. Gordon SC, Quattrociocchi-Longe TM, Khan BA, Kodali VP, Chen J, Silverman AL, Kiechle FL. Antibodies to carbonic anhydrase in patients with immune cholangiopathies. Gastroenterology 1995;108:1802-1809.
18. Taylor SL, Dean PJ, Riely CA. Primary autoimmune cholangitis. An alternative to antimitochondrial antibody-negative primary biliary cirrhosis. Am J Surg Pathol 1994;18:91-99.
19. Ben-Ari Z, Dhillon AP, Sherlock S. Autoimmune cholangiopathy: part of the spectrum of autoimmune chronic hepatitis. HEPATOLOGY 1993;18:10-15.
20. Mitchison HC, Bassendine MF, Malcolm AJ, Watson AJ, Record CO, James OF. A pilot, double-blind, controlled 1-year trial of prednisolone treatment in primary biliary cirrhosis: hepatic improvement but greater bone loss. HEPATOLOGY 1989;10:420-429.
21. Hockerstedt K. Liver transplantation: a changing concept. Transplant Proc 1994;26:1706-1707.
22. Roberts SK, Czaja AJ, Charlton MR, Hay JE, Krom RAF, Porayko MK, Wiesner RH. Recurrent autoimmune hepatitis following orthotopic liver transplantation [Abstract]. HEPATOLOGY 1995;22:215A.
23. Neuberger J, Portmann B, MacDougall BRD, Calne RY, Williams R. Recurrence of primary biliary cirrhosis after liver transplantation. N Engl J Med 1982;306:1-4.
24. Van Thiel DH, Gavaler JS. Recurrent disease in patients with liver transplantation: when does it occur and how can we be sure? HEPATOLOGY 1987;7:181-183.
25. Hubscher SG, Elias E, Buckels JAC, Mayer AD, McMaster P, Neuberger JM. Primary biliary cirrhosis. Histological evidence of disease recurrence after liver transplantation. J Hepatol 1993;18:173-184.