Manidipine improves spermatogenesis in the stroke-prone spontaneously hypertensive rat

Journal of Andrology

Volumn 18, Issue 2, 1997, Pages 210-216

  Akagashi, Keigo ^a   Kumamoto, Yoshiaki ^a   Itoh, Naoki ^a   Tsukamoto, Taiji ^a   Suzuki, Tsuneyuki ^b   Ohta, Yoshio ^b  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

insulin like growth factor I (IGF I); Testicular artery; transferrin

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; MANIDIPINE; SOMATOMEDIN C; TRANSFERRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; GERM CELL; MALE; MALE INFERTILITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGENESIS; SPONTANEOUSLY HYPERTENSIVE RAT; TESTIS BLOOD FLOW;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ARTERIOLES; ATROPHY; BLOOD PRESSURE; DIHYDROPYRIDINES; HYPERTENSION; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTIS;

EID: 0031010920     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Akagashi K, Itoh N, Kumamoto Y, Tsukamoto T, Suzuki T, Ohta Y. Hypertensive changes in intratesticular arteries impair spermatogenesis of the stroke-prone spontaneously hypertensive rat. J Androl 1996;17:367-374.
2. Andres TL, Trainer TD, Lapenas DJ. Small vessel alterations in the testes of infertile men with varicocele. Am J Clin Pathol 1981;76:378-384.
3. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principal of protein-dye binding. Anal Biochem 1976;72:248-252.
4. Chikugo T, Ohta Y, Okamoto K. The relationship among dosages, blood pressure levels and/or angiogenesis healing effects especially in renal arteriole. on SQ 29,852 and manidipine-treated M-SHRSP. Med J Kinki Univ 1981;16:41-44.
5. Dephilip RM, Feldman M, Spruill WA, French SF, Kierszenbaum AL. The secretion of androgen-binding protein and other proteins by rat Sertoli cells in culture: a structural and electrophoretic study. Ann NY Acad Sci 1982;383:360-371.
6. Dym M, Fawcett DW. The blood-testis-barrier in the rat and the physiological compartmentation of the seminiferous epithelium. Biol Reprod 1970;3:308-326.
7. Imamoto T, Nakayama T, Nagisa Y, Hamajo K, Sekiguchi M, Shino A, Nagai Y, Nagaoka A. Beneficial effects of manidipine 2HCl on neurological deficits and histological changes following cerebrovascular lesions in stroke-prone spontaneously hypertensive rats. Jpn Pharmacol Ther 1992;20:1175-1189.
8. Itoh N, Nanbu A, Tachiki H, Akagashi K, Nitta T, Mikuma N, Tsukamoto T, Kumamoto Y. Restoration of testicular transferrin, insulin-like growth factor-I (IGF-I), and spermatogenesis by exogenously administered purified FSH and testosterone in medically hypophysectomized rats. Arch Androl 1994;33:169-177.
9. Kakihana M, Suno M, Nagaoka A. Antihypertensive effect of CV-4093-2HCl, a new calcium antagonist, in three rat models of hypertension. Jpn J Pharmacol 1988;48:223-228.
10. Morimoto S, Ohyama T, Hisaki K, Matsumura Y. Effect of CV-4093, a new dihydropyridine calcium-channel blocker, on renal hemodynamics and function in stroke-prone spontaneously hypertensive rats (SHRSP). Jpn J Pharmacol 1989;51:257-265.
11. Nagaoka A, Iwatsuka H, Suzuoki Z, Okamoto K. Genetic predisposition to stroke in spontaneously hypertensive rats. Am J Physiol 1976;230:1354-1359.
12. Nagaoka A, Shibouta M, Hamajo K. Effects of a new dihydropyridine derivative, CV-4093-2HCl, on renal hemodynamics in spontaneously hypertensive rats. Jpn J Pharmacol 1989;51:25-35.
13. Nagaoka A, Shino A, Shibouta, M. Implication of renal perfusion pressure in stroke of spontaneously hypertensive rats. Am J Physiol 1980:238:H317-H324.
14. Nasah BT, Cox JN. Vascular lesions in testes associated with male infertility in Cameroon. Virchows Arch A Pathol Anal Histopathol 1978;377:225-236.
15. Okamoto K, Yamori Y, Nagaoka A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res 1974;34,35(suppl. 1):I143-I153.
16. Rodger L, Epstein M. Effects of calcium antagonists on renal hemodynamics. Am J Physiol 1985;249:619-629.
17. Shibouta Y, Kitayoshi T, Kitoh G, Nishikawa K. Calcium channel blocking action of flandipine hydrochloride (CV-4093-2HCl) in vitro and in vivo. Jpn J Pharmacol 1988;48:463-472.
18. Skinner MK, Cosand L, Griswald MD. Purification and characterization of testicular transferrin secreted by Sertoli cells. Biochem J 1984;218:313-320.
19. Spiteri-Grech J, Bartlett JMS, Nieschlag E. Hormonal regulation of epidermal growth factor and insulin-like growth factor-I in adult male hypophysectomized rats treated with ethane dimethane sulphonate. J Endocrinol 1991;129:109-117.
20. Tres LL, Smith EP, Van Wky JJ, Kierszenbaum AL. Immunoreactive sites and accumulation of somatomedin-C in rat Sertoli-spermatogenic cell co-cultures. Exp Cell Res 1986;162:33-50.
21. Vannelli BG, Natali A, Barni T, Serio M, Orlando C, Balboni GC. Insulin-like growth factor-I (IGF-I) and IGF-I receptor in human testis: an immunohistochemical study. Fertil Steril 1988;49:666-669.
22. Vannelli BG, Orlando C, Barni T, Natali A, Serio M, Nalboni GC. Immunostaining of transferrin and transferrin receptor in human seminiferous tubules. Fertil Steril 1986;45:536-541.
23. Yamamoto K. Characteristics of malignant hypertensive SHRSP (M-SHRSP) and normotensive WKY crossbred offspring. (1): establishment of 8 inbred substrains and their blood pressures and hypertensive vascular lesion incidence rates. Acta Med Kinki Univ 1989;14:91-116.