Impact of treatment changes on the interpretation of the Concorde trial

AIDS

Volumn 11, Issue 8, 1997, Pages 999-1006

  White, Ian R ^a   Walker, Sarah ^b   Babiker, Abdel G ^b   Darbyshire, Janet H ^b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Deferred treatment; HIV infection; Randomization based estimator; Treatment changes; Zidovudine

Indexed keywords

CD4 ANTIGEN; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AIDS RELATED COMPLEX; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG TOXICITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; NONBIOLOGICAL MODEL; PNEUMOCYSTIS PNEUMONIA; POLICY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL; TIME OF DEATH;

EID: 0031010553     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199708000-00008     Document Type: Article

References (13)

1. Concorde Coordinating Committee: Concorde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Lancet 1994, 343:871-881.
2. Graham N: Concorde trial of immediate versus deferred zidovudine [letter]. Lancet 1994, 343:1355-1356.
3. Havlir D, Richman DD: Antiretroviral therapy. Curr Opin Infect Dis 1995, 8:66-73.
4. Gore SM, Bird AG: Concorde trial of immediate versus deferred zidovudine [letter]. Lancet 1994, 343:1357.
5. Durrleman S, Simon R: Flexible regression models with cubic splines. Stat Med 1989, 8:551-561.
6. White IR, Pocock SJ: Statistical reporting of clinical trials with individual changes from allocated treatment. Stat Med 1996, 15:249-262.
7. Robins JM, Tsiatis AA: Correcting for non-compliance in randomized trials using rank preserving structural failure time models. Commun Stat Theory Methods 1991, 20:2609-2631.
8. Pocock SJ: Clinical Trials: A Practical Approach. Chichester: Wiley; 1983.
9. Newell DJ: Intention-to-treat analysis: implications for quantitative and qualitative research. Int J Epidemiol 1992, 21:837-841.
10. Oakes D, Moss AJ, Fleiss JL, et al.: Use of compliance measures in an analysis of the effect of diltiazem on mortality and reinfarction after myocardial infarction. J Am Stat Assoc 1993, 88:44-49.
11. Mark SD, Robins JM: A method for the analysis of randomised trials with compliance information: an application to the multiple risk factor intervention trial. Controlled Clin Trials 1993, 14:79-97.
12. Robins JM, Greenland S: Adjusting for differential rates of prophylaxis therapy for PCP in high-dose versus low-dose AZT treatment arms in an AIDS randomized trial. J Am Stat Assoc 1994, 89:737-749.
13. Siegel S, Castellan NJ: Nonparametric Statistic for the Behavioral Sciences. New York: McGraw-Hill; 1988.