An appraisal of the pharmacological and toxicological effects of a single oral administration of 3,4-methylenedioxymethamphetamine (MDMA) in the rat

Pharmacology and Toxicology

Volumn 80, Issue 5, 1997, Pages 207-210

  De Souza, I ^a   Kelly, J P ^a   Harkin, A J ^a   Leonard, B E ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL MODEL; ARTICLE; DEATH; DOSE RESPONSE; FEMALE; FLUID INTAKE; FOOD INTAKE; HYPERTHERMIA; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SEROTONIN SYNDROME; WEIGHT REDUCTION;

ANIMALIA;

EID: 0031010421     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb01961.x     Document Type: Article

References (26)

1. Callaway, C. W., L. Wing, & M. A. Geyer: Serotonin release contributes to the stimulant effects of 3,4 methylenedioxymethamphetamine in rats. J. Pharmacol. Exp. Therap. 1990, 254, 456-464.
2. Coore, J. R.: A fatal trip with ecstasy - a case of 3,4-methylenedioxymethamphetamine toxicity. J. Royal Soc. Med. 1996, 89, 5-52.
3. Derelenko, M. J.: Notification of new substances in the European Community. In: CRC Handbook of Toxicology. CRC Press, Florida, 1995, pp.763-770.
4. Geyer, M. A.: Serotonergic functions in arousal and motor activity. Behav. Brain Res. 1995, 73, 31-35.
5. Gold, L. H. & G. F. Koob: Methysergide potentiates the hyperactivity produced by MDMA in rats. Pharmacol. Biochem. Behav. 1988, 29, 645-648.
6. 2 receptors. Brit. J. Pharmacol. 1987, 84, 743-753.
7. 1A receptors). Neuropharmacology 1986, 25, 1307-1313.
8. Henry, J. A.: Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy"). Lancet 1992, 340, 386-387.
9. Hernandez, A. F., M. N. Montero, A. Pla & E. Villaneuva: Fatal moclobemide overdose or death caused by serotonin syndrome. J. Forensic Sci. 1995, 40, 128-130.
10. McCann, U., G. Hatzidimitriou, A. Ridenour, C. Fischer, J. Yuan, J. Katz & G. Ricaurte: Dexfenfluramine and serotonin neurotoxicity - further pre clinical evidence that clinical caution is indicated. J. Pharmacol. Exp. Therap. 1994, 269, 792-798.
11. McKenna, D. J. & S. J. Peroutka: Neurochemistry and neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"). J. Neurochem. 1990, 54, 14-21.
12. McNamara, M. G., J. P. Kelly & B. E. Leonard: Thermoregulatory and locomotor activity responses of 3,4-methylenedioxymethamphetamine (MDMA) in male and female rats. J Serotonin Res. 1995, 1, 275-282.
13. Nash, J. F. Jr. H. Y. Meltzer & G. A. Gudelsky: Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J. Pharmacol. Exp. Therap. 1988, 245, 873-879.
14. Nsimba, S. E. D., J. P. Kelly & B. E. Leonard: Dose-dependent behavioural effects of phencyclidine (PCP). Med. Sci. Res. 1994, 22, 207-209.
15. O'Connor, B: Hazards associated with the recreational drug Ecstasy. Brit. J. Hosp. Med. 1994, 57, 507-512.
16. Peroutka, S. J., H. Newman & H. Harris: Subjective effects of 3,4-methylenedioxy methamphetamine in recreational users. Neuropsychopharmacology. 1988, 1, 273-277.
17. Power, B. M., M. Pinder, L. P. Hackett & K. F. Ilett: Fatal serotonin syndrome following a combined overdose of moclobemide, clomipramine and fluoxetine. Anaesth. Intensive Care 1995, 23, 499-502.
18. Riley, V: Adaptation of orbital bleeding technic to rapid serial blood studies. Proc. Soc. Exp. Biol. Med. 1960, 104, 751-753.
19. Schmidt, C. J.: Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J. Pharmacol. Exp. Therap. 1987, 240, 1-7.
20. 2 receptors. Brain Res. 1990, 529, 85-90.
21. Series, H., S. Boeles, E. Dorkins & R. Peveler: Psychiatric complications of Ecstasy use. J. Psychopharmacol. 1994, 8, 60-61.
22. Shulgin, A. T.: The background and chemistry of MDMA. J. Psychoactive Drugs 1986, 18, 291-300.
23. Siegel, R. K.: MDMA: nonmedical use and intoxication. J. Psychoactive Drugs. 1986, 18, 349-354.
24. Spanos, L. J. & B. K. Yamamoto: Acute and subchronic effects of methylenedioxymethamphetamine (MDMA) on locomotion and serotonin syndrome behaviour in the rat. Pharmacol. Biochem. Behav. 1989, 32, 835-840.
25. Stone, D. M., D. C. Stahl, G. R. Hanson & J. W. Gibb: The effects of 3,4methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain. Eur. J. Pharmacol. 1986, 128, 41-48.
26. Tamborini, P., H. Sigg & G. Zbinden: Acute toxicity in a non lethal dose range: a new approach. Regulat. Toxicol. Pharmacol. 1990, 12, 69-87.