Amine precursor uptake and decarboxylation: Significance for processing of the rat gastrin precursor

Journal of Physiology

Volumn 501, Issue 2, 1997, Pages 363-374

  Voronina, Svetlana ^a   Henry, Julie ^a   Vaillant, Camille ^a   Dockray, Graham J ^a   Varro, Andrea ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; AMINO ACID DECARBOXYLASE; BAFILOMYCIN A1; BIOGENIC AMINE; CARBIDOPA; CHLOROQUINE; GASTRIN; HORMONE PRECURSOR; IONOPHORE; LEVODOPA; MONENSIN; PROGASTRIN; PROTEIN PRECURSOR; PROTON PUMP; RESERPINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL PH; CELL STRUCTURE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DECARBOXYLATION; DRUG EFFECT; ELECTRON MICROSCOPY; ENZYME INHIBITION; GASTRIN CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOPRECIPITATION; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MUCOSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RAT; SECRETORY GRANULE;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BIOGENIC AMINES; CARBIDOPA; DECARBOXYLATION; DOPAMINE AGENTS; GASTRIC MUCOSA; GASTRINS; HYDROGEN-ION CONCENTRATION; LEVODOPA; MALE; MICROSCOPY, ELECTRON; PRECIPITIN TESTS; PROTEIN PRECURSORS; PROTONS; RATS; RATS, WISTAR; RESERPINE;

EID: 0031009406     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.363bn.x     Document Type: Article

References (32)

1. ANDERSON, R. G. W. & ORCI, L. (1988). A view of acidic intracellular compartments. Journal of Cell Biology 106, 539-543.
2. BAILYES, E. M., SHENNAN, K. I. J., SEAL, A. J., SMEEKENS, S. P., STEINER, D. F., HUTTON, J. C. & DOCHERTY, K. (1992). A member of the eukaryotic subtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. Biochemical Journal 285, 391-394.
3. BENNETT, D. L., BAILYES, E. M., NIELSEN, E., GUEST, P. C., RUTHERFORD, N. G., ARDEN, S. D. & HUTTON, J. C. (1992). Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. Journal of Biological Chemistry 267, 15229-15236.
4. CHANAT, E. & HUTTNER, W. B. (1991). Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. Journal of Cell Biology 115, 1505-1519.
5. COLOMER, V., KIESKA, G. A. & RINDLERS, M. J. (1996). Secretory granule content proteins and the luminal domains of granule membrane proteins aggregate in vitro at mildly acidic pH. Journal of Biological Chemistry 271, 48-55.
6. DAVIDSON, H. W., RHODES, C. J. & HUTTON, J. C. (1988). Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases. Nature 333, 93-96.
7. DELVALLE, J. & YAMADA, T. (1990). Amino acids and amines stimulate gastrin release from canine antral G-cells via different pathways. Journal of Clinical Investigation 85, 139-143.
8. DIAL, E. J., COOPER, L. C. & LICHTENBEROER, L. M. (1991). Amino acid- and amine-induced gastrin release from isolated rat endocrine granules. American Journal of Physiology 260, G175-181.
9. DICKINSON, C. J., SAWADA, M., GUO, Y. J., FINNISS, S. & YAMADA, T. (1995). Specificity of prohormone convertase endoproteolysis of Progastrin in AtT-20 cells. Journal of Clinical Investigation 96, 1425-1431.
10. DOCHERTY, K. & STEINER, D. F. (1982). Post-translational proteolysis in polypeptide hormone biosynthesis. Annual Review of Physiology 44, 625-638.
11. DOCKRAY, G. J. & GREGORY, R. A. (1989). Gastrin. In The Gastrointestinal System II, 2nd edn, ed. MAKHLOUF, G. M., pp. 311-336. American Physiological Society, Bethesda, Maryland.
12. DOCKRAY, G. J., VARRO, A. & DIMALINE, R. (1996). Gastric endocrine cells: gene expression, processing, and targeting of active products. Physiological Reviews 76, 767-798.
13. EKELUND, M., AHREN, B., HAKANSON, R., LUNDQUIST, I. & SUNDLER, F. (1980). Quinacrine accumulates in certain peptide hormone-producing cells. Histochemistry 66, 1-9.
14. ERICKSON, J. D., EIDEN, L. E. & HOFFMAN, B. J. (1992). Expression cloning of a reserpine-sensitive vesicular monoamine transporter. Proceedings of the National Academy of Sciences of the USA 89, 10993-10997.
15. GREGORY, R. A. & TRACY, H. J. (1964). The constitution and properties of two gastrins extracted from hog antral mucosa. Gut 5, 103-114.
16. GREGORY, R. A. & TRACY, H. J. (1972). Isolation of two 'big gastrins' from Zollinger-Ellison tumour tissue. Lancet 2, 797-799.
17. HAKANSON, R. (1970). New aspects of the formation and function of histamine, 5-hydroxytryptamine and dopamine in gastric mucosa. Acta Physiologica Scandinavica 340S, 1-134.
18. HUTTNER, W. B. (1988). Tyrosine sulfation and the secretory pathway. Annual Review of Physiology 50, 363-376.
19. JOHNSON, R. G. JR (1988). Accumulation of biological amines into chromaffin granules: a model for hormone and neu retransmitter transport. Physiological Reviews 68, 232-307.
20. LANGLEY, K. (1994). The neuroendocrine concept today. Annals of the New York Academy of Science 733, 1-17.
21. LICHTENBERGER, L. M., DELANSORNE, R. & GRAZIANI, L. A. (1982). Importance of amino acid uptake and decarboxylation in gastrin release from isolated G cells. Nature 295, 698-700.
22. MACRO, J. A., DIMALINE, R. & DOCKRAY, G. J. (1996). Identification and expression of prohormone-converting enzymes in the rat stomach. American Journal of Physiology 279, G87-93.
23. MELLMAN, I., FUCHS, R. & HELENIUS, A. (1986). Acidification of the endocytic and exocytic pathways. Annual Review of Biochemistry 55, 663-700.
24. PEARSE, A. G. E. (1969). The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. Journal of Histochemistry and Cytochemistry 17, 303-313.
25. PETER, D., JIMENEZ, J., LIU, Y., KIM, J. & EDWARDS, R. H. (1994). The 'chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors. Journal of Biological Chemistry 269, 7231-7237.
26. RAHIER, J., PAUWELS, S. & DOCKRAY, G. J. (1987). Biosynthesis of gastrin: localization of the precursor and peptide products using electron microscopic-immunogold methods. Gastroenterology 92, 1146-1152.
27. VAILLANT, C., MACRO, J. A., VARRO, A., DOCKRAY, G. J., DIMALINE, R. & SEIDAH, N. G. (1996). Prohormone processing enzymes in G-cells of the rat antral mucosa. Regulatory Peptides 64, 195 (abstract).
28. VARRO, A., HENRY, J., VAILLANT, C. & DOCKRAY, G. J. (1994). Discrimination between temperature- and brefeldin A-sensitive steps in the sulfation, phosphorylation, and cleavage of progastrin and its derivatives. Journal of Biological Chemistry 269, 20764-20770.
29. VARRO, A., VORONINA, S. & DOCKRAY, G. J. (1995). Pathways of processing of the gastrin precursor in rat antral mucosa. Journal of Clinical Investigation 95, 1642-1649.
30. WALSH, J. H., DEBAS, H. T. & GROSSMAN, M. I. (1974). Pure human big gastrin: immunochemical properties, disappearance half time and acid stimulating action in dogs. Journal of Clinical Investigation 54, 477-485.
31. WALSH, J. H., ISENBERG, J. I., ANSFIELD, J. & MAXWELL, V. (1976). Clearance and acid-stimulating action of human big and little gastrins in duodenal ulcer subjects. Journal of Clinical Investigation 57, 1125-1131.
32. +-ATPases in the secretory pathway of HepG2 cells. Journal of Biological Chemistry 268, 19092-19100.