Human Placenta Does Not Reduce AZT (Zidovudine) to 3′-Amino-3′-Deoxythymidine

Experimental Biology and Medicine

Volumn 215, Issue 3, 1997, Pages 243-247

  Plessinger, Mark A ^a   Boal, Jila H ^a,b   Miller, Richard K ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' AMINO 3' DEOXYTHYMIDINE; ANTIVIRUS AGENT; DRUG METABOLITE; ZIDOVUDINE;

ARTICLE; CELL PROLIFERATION; CHORIOCARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG METABOLISM; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PLACENTA; PLACENTA CIRCULATION; PREGNANCY; TOXICITY TESTING; TROPHOBLAST;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE TECHNIQUES; DIDEOXYNUCLEOSIDES; FEMALE; HUMANS; PLACENTA; PREGNANCY; TUMOR CELLS, CULTURED; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; MINO;

EID: 0031009276     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.3181/00379727-215-44134     Document Type: Article

References (24)

1. Centers for Disease Control. Zidovudine for the prevention of HIV transmission from mother to infant. MMWR 43:285-287, 1994.
2. Ayers KM. Preclinical toxicology of zidovudine. Am J Med 85:186-188, 1988.
3. Greene JA, Ayers KM, DeMiranda P, Tucker WE Jr. Postnatal survival in Wistar rats following oral dosage with zidovudine on gestation day 10. Fund Appl Toxicol 15:201-206, 1990.
4. Sieh E, Coluzzi ML, DeAngelis MGC, Mezzogiorno A, Floridia M, Canipari R, Cossu G, Vella S. The effects of AZT and DDI on pre- and postimplantation mammalian embryos: An in vivo and in vitro study. AIDS Res Hum Retrovir 8:639-649, 1992.
5. Stahlmann R, Chahoud I, Bochert G, Klug S, Korte M, Neubert D. Prenatal toxicity of zidovudine in rats. Teratology 38:28A, 1988.
6. Toltzis P, Marx CM, Kleinman N, Levine EM, Schmidt EV. Zidovudine-associated embryonic toxicity in mice. J Infect Dis 163:1212-1218, 1991.
7. Bui T, Bark D, Perkins M, Vu H, Unadkat JD, Ho RJY. Effect of Zidovudine on human placental trophoblast and Hofbauer cell functions. J Acquir Immune Defic Syndr 6:120-126, 1993.
8. Plessinger MA, Miller RK. Toxic effects of the anti-HIV drugs, dideoxyinosine (ddI) and zidovudine (AZT) upon human trophoblast cells. Toxicologist 14:149, 1994.
9. Boal JH, Plessinger MA, van den Reydt C, Miller RK. Pharmacokinetic and toxicity studies of AZT (Zidovudine) following perfusion of human term placenta for 14 hours. Toxicol Appl Pharmacol 143:13-21, 1997.
10. Cretton EM, Xie M-Y, Bevan RJ, Goudgaon NM, Schinazi RF, Sommadossi J-P. Catabolism of 3′-azido-3′-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3′-amino-3′-deoxythymidine, a highly toxic catabolite for human bone marrow cells. Mol Pharmacol 39:258-266, 1991.
11. Stagg MP, Cretton EM, Kidd L, Diasio RB, Sommadossi J-P. Clinical pharmacokinetics of 3′-azido-3′-deoxythymidine (zidovudine) and catabolites with formation of a toxic catabolite, 3′-amino-3′-deoxythymidine. Clin Pharmacol Ther 51:668-676, 1992.
12. Richman DD, Fischl MA, Grieco MH, Gottlieb MS, Volberding PA, Laskin OL, Leedom JM, Groopman JE, Mildvan D, Hirsch MS, Nusinoff-Lehrman S, Jackson GG, Durack DT, the AZT Collaborative Group. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N Engl J Med 317:192-197, 1987.
13. Northfelt DW, Mitsuyasu RT. Hematologic complications of HIV infection. In: DeVita VT, Hellman S, Rosenberg SA, Eds. AIDS, Etiology, Diagnosis, Treatment, and Prevention. Philadelphia: Lippincott, pp337-345, 1992.
14. Volberding PA. Clinical applications of antiviral therapy: Use of Zidovudine. In: Cohen PT, Sande MA, Volberding PA, Eds. The AIDS Knowledge Base. Waltham, PA: Medical Publishing Group, pp4.2.5.1-4.2.5.5, 1990.
15. Asai M, Faber W, Neth-Jessee L, di Sant'Agnese PA, Nakanishi M, Miller RK. Human placental transport and metabolism of all-trans retinoic acid in vitro. Trophoblast Res 7:25-33, 1993.
16. Placidi L, Cretton EM, Placidi M, Sommadossi J-P. Reduction of 3′-azido-3′-deoxythymidine to 3′-amino-3′-deoxythymidine in human liver microsomes and its relationship to cytochrome P450. Clin Pharmacol Ther 54:168-176, 1993.
17. Pasanen M, Pelkonen O. The expression and environmental regulation of P450 enzymes in the human placenta. Crit Rev Toxicol 24:211-229, 1994.
18. Bergheim P, Rathgen GH, Netter KJ. Interaction of drugs and steroids with human placental microsomes. Biochem Pharmacol 22:1633-1645, 1973.
19. Juchau MR, Symms KG. Aniline hydroxylation in the human placenta-mechanistic aspects. Biochem Pharmacol 21:2053-2064, 1972.
20. Patillo RA, Gey GO. The establishment of a cell line of human hormone-synthesizing trophoblast cells in vitro. Cancer Res 28:1231-1236, 1968.
21. Klecker RW Jr., Collins JM, Yarchoan R, Thomas R, Jenkins JF, Broder S, Myers CE. Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases. Clin Pharmacol Ther 41:407-412, 1987.
22. Schröder JM, Bertram M, Schnabel R, Pfaff U. Nuclear and mitochondrial changes of muscle fibers in AIDS after treatment with high doses of Zidovudine. Acta Neuropathol 85:39-47, 1992.
23. Miller RK, Wier PJ, Maulik D, di Sant'Agnese PA. Human placenta in vitro: Characterization during 12 hours of dual perfusion. Contrib Gynecol Obstet 13:77-84, 1985.
24. Miller RK, Wier PJ, Perez-D'Gregorio R, Eisenmann C, di Sant'Agnese PA, Shah Y, Neth-Jessee L. Human dual placental perfusions - Criteria for toxicity evaluations. Methods Toxicol 3B:246-259, 1993.