Efficient preparation of aminoacylated dinucleoside phosphates with N-FMOC amino acid fluorides

Tetrahedron Letters

Volumn 38, Issue 23, 1997, Pages 4005-4008

  Oliver, John S ^a   Oyelere, Adegboyega K ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; DINUCLEOSIDE PHOSPHATE; FUNCTIONAL GROUP;

AMINOACYLATION; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS;

EID: 0031009099     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00820-4     Document Type: Article

References (24)

1. Abbreviations used: FMOC, [(9-fluorenylmethyl)oxy]carbonyl; T, thymidine; DMT, dimethoxytrityl; TBAF, tetrabutyl ammonium fluoride; BPOC, [[2-(4-biphenylyl)isopropyl]oxy]carbonyl; HOBt, 1-hydroxybenzotriazole.
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19. We have found that the FMOC and β-cyanoethyl groups are removed by tetramethylguanidine without the necessity of adding oximate. We thank a reviewer for this suggestion.
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21. 3 to give 1 as a white solid
22. + 1293.4198, found 1293.4235.
23. + 716.1945, found 716.1963.
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