Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme

Lipids

Volumn 32, Issue 6, 1997, Pages 605-610

  Wynn, James P ^a   Kendrick, Andrew ^a,b   Ratledge, Colin ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; LIPID; MALATE DEHYDROGENASE (DECARBOXYLATING); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SESAME SEED OIL;

ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; FUNGUS GROWTH; LIPID METABOLISM; METABOLITE; MUCOR; NONHUMAN; YEAST;

ANTIOXIDANTS; CATECHOLS; DIOXOLES; FUNGI; LIPID METABOLISM; MALATE DEHYDROGENASE; MUCOR; PHENOLS; STRUCTURE-ACTIVITY RELATIONSHIP; YEASTS;

EID: 0031008664     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-997-0077-1     Document Type: Article

References (24)

1. Shimizu, S., Akimoto, K., Kawashima, H., Shinmen, Y., and Yamada, H. (1989) Production of Dihomo-γ-linolenic Acid by Mortierella alpina 1S-4, J. Am. Oil Chem. Soc. 66, 237-241.
2. Shimizu, S., Akimoto, K., Shinmen, Y., Kawashima, H., Sugano, M., and Yamada, H. (1991) Sesamin Is a Potent and Specific Inhibitor of Δ5 Desaturase in Polyunsaturated Fatty Acid Biosynthesis, Lipids 26, 512-516.
3. Kendrick, A., and Ratledge, C. (1996) Cessation of Polyunsaturated Fatty Acid Formation in Four Selected Filamentous Fungi When Grown on Plant Oils, J. Am. Oil Chem. Soc. 73, 431-435.
4. Kendrick, A. (1991) The Fungal Production of Polyunsaturated Fatty Acids Currently Considered of Dietetic Importance, Ph.D. Thesis, University of Hull.
5. Ratledge, C. (1992) Microbial Lipids: Commercial Realities or Academic Curiosities, in Industrial Applications of Single Cell Oils (Kyle, D.J., and Ratledge, C., eds.), pp. 1-15, American Oil Chemists' Society, Champaign.
6. Kendrick, A., and Ratledge, C. (1992) Desaturation of Polyunsaturated Fatty Acids in Mucor circinelloides and the Involvement of the Novel Membrane-Bound Malic Enzyme, Eur. J. Biochem. 209, 667-673.
7. Wynn, J.P., and Ratledge, C. (1997) Malic Enzyme Is a Major Source of NADPH for Lipid Accumulation by Aspergillus nidulans, Microbiology 143, 253-257.
8. Bradford, M.M. (1976) A Rapid Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding, Anal. Biochem. 72, 248-254.
9. De Spiegeleer, B., Mannens, G., Sieger, G., Van den Bossche, W., and Claeys, A. (1986) Direct Assay for Phosphotransacetylase and Acetyl-Coenzyme A Carboxylase by High-Performance Liquid Chromatography, Anal. Biochem. 158, 195-200.
10. Srere, P.A. (1959) The Citrate Cleavage Enzyme. 1. Distribution and Purification, J. Biol. Chem. 234, 2544-2547.
11. Hsu, R.Y., and Lardy, H.A. (1969) Malic Enzyme, Meth. Enzymol. 13, 230-235.
12. Ochoa, S. (1955) Malic Dehydrogenase from Pig Heart, Meth. Enzymol. 1, 735-739.
13. Langdon, R.C. (1966). Glucose 6-phosphate Dehydrogenases from Erythrocytes, Meth. Enzymol. 9, 126-131.
14. Pontremoli, S., and Grazi, E. (1966). 6-Phosphogluconate Dehydrogenase-Crystalline, Meth. Enzymol. 9, 137-141.
15. Kornberg, A. (1955) Isocitric Dehydrogenase of Yeast (TPN), Meth. Enzymol. 1, 705-709.
16. Stoops, J.K., Awad, E.S., Arslannian, M.J., Gunsberg, S., and Wakil, S.J. (1978) Studies on the Yeast Fatty Acid Synthetase, Subunit Composition and Structural Organization of a Large Multifunctional Enzyme Complex, J. Biol. Chem. 253, 4464-4475.
17. Folch, J., Lees, M., and Sloane-Stanley, G.H. (1957) A Simple Method for the Isolation and Purification of Lipids from Animal Tissues, J. Biol. Chem. 226, 497-509.
18. Butte, W. (1983) Rapid Method for the Determination of Fatty Acid Profiles from Fats and Oils Using Trimethylsulphonium Hydroxide for Transesterification, J. Chromatogr. 261, 142-145.
19. Jackson, M.A., and Lanser, A.C. (1993) Glucose and Zinc Concentration Influence Fusarin-C Synthesis, Ethanol Synthesis, and Lipid Composition in Fusarium moniliforme Submerged Cultures, FEMS Microbiol. Lett. 108, 69-73.
20. Zink, M.W. (1972) Regulation of the Two "Malic" Enzymes in Neurospora crassa, Can. J. Microbiol. 18, 611-617.
21. Essaac, E.G., and Casida, J.E. (1969) Metabolism in Relation to Mode of Action of Methylenedioxyphenol Synergists in Houseflies, J. Agric. Food Chem. 17, 539-550.
22. Yamonoto, I., Kimmel, E.C., and Casida, J.E. (1969) Oxidative Metabolism of Pyrethroids in Houseflies, J. Agric. Food Chem 17, 1227-1236.
23. Mason, H.S., North, J.C., and Vanneste, M. (1965) Microsomal Mixed Function Oxidations: The Metabolism of Xenobiotics, Fed. Proc. 24, 1172-1180.
24. 14-Dioxyphenyl Compounds: Metabolism in Relation to Their Synergistic Action, Science 153, 1130-1133.