Plasticizer uptake by aqueous colloidal polymer dispersions used for the coating of solid dosage forms

International Journal of Pharmaceutics

Volumn 152, Issue 1, 1997, Pages 17-26

  Bodmeier, Roland ^a   Paeratakul, Ornlaksana ^b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Aquacoat ; Aqueous colloidal polymer dispersion; Coating; Controlled drug release; Ethyl cellulose; Eudragit ; Plasticizer

Indexed keywords

CITRIC ACID TRIBUTYL ESTER; CITRIC ACID TRIETHYL ESTER; ETHYL CELLULOSE; EUDRAGIT; EUDRAGIT RS; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID DIETHYL ESTER; PLASTICIZER; POLYMER; TRIACETIN;

ARTICLE; COLLOID; CONTROLLED DRUG RELEASE; DRUG COATING; PRIORITY JOURNAL;

EID: 0031008354     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)04882-5     Document Type: Article

References (16)

1. Bodmeier, R. and Paeratakul, O: Process and formulation variables affecting the drug release from chlorpheniramine maleate-loaded beads coated with commercial and self-prepared aqueous ethyl cellulose pseudolatexes. Int. J. Pharm., 70 (1991a) 59-68.
2. Bodmeier, R. and Paeratakul, O., Determination of plasticizers commonly used in pharmaceutical dosage forms by high performance liquid chromatography. J. Liq. Chromatogr., 14 (1991b) 365-375.
3. Bodmeier, R. and Paeratakul, O: The distribution of plasticizers between aqueous and polymer phases in aqueous colloidal polymer dispersions. Int. J. Pharm., 103 (1994a) 47-54.
4. Bodmeier, R. and Paeratakul, O: The effect of curing on drug release and morphological properties of ethylcellulose pseudolatex-coated beads. Drug Dev. Ind. Pharm., 20(9) (1994b) 1517-1533.
5. Dillon, R.E., Bradford, E.B. and Andrews, R.D., Plasticizing synthetic latexes. Ind. Eng. Chem., 45 (1953) 728-735.
6. Felton, L.A. and McGinity, J.W., The influence of plasticizers on the adhesive properties of acrylic resin copolymers. 15th Pharm. Technol. Conf., Oxford, Vol. 1, 1996, pp. 69-70.
7. Hennig, D. and Kala, H., Einfluß von Weichmachern auf die Permeabilität von Polymethacrylatüberzügen (Eudragit RS®). Pharmazie, (1986) 335-338.
8. Hoy, K.L., Estimating the effectiveness of latex coalescing aids. J. Paint Technol., 45 (1973) 51-56.
9. Hutchings, D.E. and Sakr, A., Influence of pH and plasticizers on drug release from ethylcellulose pseudolatex coated pellets. J. Pharm. Sci., 83(10) (1994) 1386-1390.
10. Iyer, U., Hong, W.-H., Das, N. and Ghebre-Sellassie, I., Comparative evaluation of three organic solvent and dispersion-based ethylcellulose coating formulations. Pharm. Technol., 14 (1990) 68-86.
11. Lehmann, K.O.R., Chemistry and application properties of polymethacrylate coating systems. In McGinity, J.W. (Ed.), Aqueous Polymeric Coatings for Pharmaceutical Applications, Dekker, New York, 1989, pp. 153-245.
12. Lin, S.-Y., Lee, C.-J. and Lin, Y.-Y., The effect of plasticizers on the compatibility, mechanical properties, and adhesion strength of drug-free Eudragit E films. Pharm. Res., 8(9) (1991) 1137-1143.
13. Lippold, B.H., Sutter, B.K. and Lippold, B.C., Parameters controlling drug release from pellets coated with aqueous ethyl cellulose dispersions. Int. J. Pharm., 54 (1989) 15-25.
14. Morton, M., Kaizerman, S. and Altier, M.W., Swelling of latex particles. J. Colloid. Sci., 9 (1954) 300-312.
15. Steuernagel, C.R., Latex emulsions for controlled drug delivery. In McGinity, J.W. (Ed.), Aqueous Polymeric Coatings for Pharmaceutical Applications, Dekker, New York, 1989, pp. 1-61.
16. Sutter, B., Aqueous Ethyl Cellulose Dispersions for Preparing Microcapsules with Controlled Drug Release. Ph.D. Thesis, University of Düsseldorf, West Germany, 1987.