-
1
-
-
0024412071
-
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver: CDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine
-
AOYAMA, T., YAMANO, S., WAXMAN, D.J., LAPENSON, D.P., MEYER, U.A., FISHER, V., TYNDALE, R., INABA, T., WERNER, K., GELBOIN, H.V., and GONZALEZ, F.J. (1989). Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver: cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J. Biol. Chem. 264, 10388-10395.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 10388-10395
-
-
Aoyama, T.1
Yamano, S.2
Waxman, D.J.3
Lapenson, D.P.4
Meyer, U.A.5
Fisher, V.6
Tyndale, R.7
Inaba, T.8
Werner, K.9
Gelboin, H.V.10
Gonzalez, F.J.11
-
2
-
-
0029036087
-
Interaction between two probes used for phenotyping cytochrome P450 1A2 (caffeine) and P450 2E1 (chlorzoxazone) in humans
-
BERTHOU, F., GOASDUFF, T., LUCAS, D., DREANO, Y., LE BOT, M.H., and MÉNEZ, J.F. (1995). Interaction between two probes used for phenotyping cytochrome P450 1A2 (caffeine) and P450 2E1 (chlorzoxazone) in humans. Pharmacogenetics 5, 72-79.
-
(1995)
Pharmacogenetics
, vol.5
, pp. 72-79
-
-
Berthou, F.1
Goasduff, T.2
Lucas, D.3
Dreano, Y.4
Le Bot, M.H.5
Ménez, J.F.6
-
3
-
-
0025848338
-
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6
-
CRESPI, C.L., PENMAN, B.W., GELBOIN, H.V., and GONZALEZ, F.J. (1991). A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. Carcinogenesis 12, 1197-1201.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1197-1201
-
-
Crespi, C.L.1
Penman, B.W.2
Gelboin, H.V.3
Gonzalez, F.J.4
-
4
-
-
0025179176
-
Human cytochrome P450IIA3: CDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1
-
CRESPI, C.L., PENMAN, B.W., LEAKEY, J.A.E., ARLOTTO, M.P., STARK, A., PARKINSON, A., TURNER, T., STEIMEL, D.T., RUDO, K., DAVIES, R.L., and LANGENBACH, R. (1990). Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1. Carcinogenesis 11, 1293-1300.
-
(1990)
Carcinogenesis
, vol.11
, pp. 1293-1300
-
-
Crespi, C.L.1
Penman, B.W.2
Leakey, J.A.E.3
Arlotto, M.P.4
Stark, A.5
Parkinson, A.6
Turner, T.7
Steimel, D.T.8
Rudo, K.9
Davies, R.L.10
Langenbach, R.11
-
5
-
-
0029033092
-
Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture
-
DONATO, M.T., CASTELL, J.V., and GOMEZ-LECHON, M.J. (1995). Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture. Drug Metab. Dispos. 23, 553-558.
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 553-558
-
-
Donato, M.T.1
Castell, J.V.2
Gomez-Lechon, M.J.3
-
6
-
-
0029163541
-
Nitric oxide and ethylnitrosurea: Relative mutagenicity in the p53 tumor suppressor and hypoxanthine-phosphoribosyltransferase genes
-
FELLEY-BOSCO, E., MIRKOVITCH, J., AMBS, S., MACÉ, K., PFEIFER, A., KEEPER, L.K., and HARRIS, C.C. (1995). Nitric oxide and ethylnitrosurea: Relative mutagenicity in the p53 tumor suppressor and hypoxanthine-phosphoribosyltransferase genes. Carcinogenesis 16, 2069-2074.
-
(1995)
Carcinogenesis
, vol.16
, pp. 2069-2074
-
-
Felley-Bosco, E.1
Mirkovitch, J.2
Ambs, S.3
MacÉ, K.4
Pfeifer, A.5
Keeper, L.K.6
Harris, C.C.7
-
7
-
-
0026082836
-
cDNA-expressed human cytochrome P450s: A new age of molecular toxicology and human risk assessment
-
GONZALEZ, F.J., CRESPI, C.L., and GELBOIN, H.V. (1991). cDNA-expressed human cytochrome P450s: A new age of molecular toxicology and human risk assessment. Mutat. Res. 247, 113-127.
-
(1991)
Mutat. Res.
, vol.247
, pp. 113-127
-
-
Gonzalez, F.J.1
Crespi, C.L.2
Gelboin, H.V.3
-
8
-
-
0023854270
-
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
-
GONZALEZ, F.J., SKODA, R.C., KIMURA, S., UMENO, M., ZANGER, U.M., NEBERT, D.W., GELBOIN, H.V., HARDWICK, J.P., and MEYER, U.A. (1988a). Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331, 442-446.
-
(1988)
Nature
, vol.331
, pp. 442-446
-
-
Gonzalez, F.J.1
Skoda, R.C.2
Kimura, S.3
Umeno, M.4
Zanger, U.M.5
Nebert, D.W.6
Gelboin, H.V.7
Hardwick, J.P.8
Meyer, U.A.9
-
9
-
-
0023858226
-
Human P450PCN1: Sequence, chromosome, localization and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase
-
GONZALEZ, F.J., B.J. UMENO, M., MCBRIDE, O.W., HARDWICK, J.P., MEYER, U.A., GELBOIN, H.V., and IDLE, J.R. (1988b). Human P450PCN1: Sequence, chromosome, localization and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 7, 76-86.
-
(1988)
DNA
, vol.7
, pp. 76-86
-
-
Gonzalez, F.J.1
J., B.2
Umeno, M.3
Mcbride, O.W.4
Hardwick, J.P.5
Meyer, U.A.6
Gelboin, H.V.7
Idle, J.R.8
-
10
-
-
0020466499
-
Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium
-
LECHNER, J.F., HAUGEN, A., MCCLENDON, I.A., and PETTIS, E.W. (1982). Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium. In Vitro 18, 633-642.
-
(1982)
In Vitro
, vol.18
, pp. 633-642
-
-
Lechner, J.F.1
Haugen, A.2
Mcclendon, I.A.3
Pettis, E.W.4
-
11
-
-
0022357460
-
A serum-free method for culturing normal human bronchial epithelial cells at clonal density
-
LECHNER, J.F., and LA VECK, M.A. (1985). A serum-free method for culturing normal human bronchial epithelial cells at clonal density. J. Tissue Culture Methods 9, 43-48.
-
(1985)
J. Tissue Culture Methods
, vol.9
, pp. 43-48
-
-
Lechner, J.F.1
La Veck, M.A.2
-
12
-
-
0028171339
-
Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2
-
MACÉ, K., GONZALEZ, F.J., MCCONNELL, I.R., GARNER, R.C., AVANTI, O., HARRIS, C.C., and PFEIFER, A.M.A. (1994). Activation of promutagens in a human bronchial epithelial cell line stably expressing human cytochrome P450 1A2. Mol. Carcinogen. 11, 65-73.
-
(1994)
Mol. Carcinogen.
, vol.11
, pp. 65-73
-
-
MacÉ, K.1
Gonzalez, F.J.2
Mcconnell, I.R.3
Garner, R.C.4
Avanti, O.5
Harris, C.C.6
Pfeifer, A.M.A.7
-
13
-
-
0001285525
-
Drug metabolism and carcinogen activation studies with human genetically engineered cells
-
J.V. Castell and M.J. Gomez-Lechon (eds.) Academic Press: London
-
MACÉ, K., OFFORD, E.A., and PFEIFER, A.M.A. (1996). Drug metabolism and carcinogen activation studies with human genetically engineered cells, in: In Vitro Methods in Pharmceutical Research. J.V. Castell and M.J. Gomez-Lechon (eds.) Academic Press: London, pp. 433-456.
-
(1996)
In Vitro Methods in Pharmceutical Research
, pp. 433-456
-
-
MacÉ, K.1
Offord, E.A.2
Pfeifer, A.M.A.3
-
14
-
-
29344433717
-
Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells
-
In Press
-
OFFORD, E.A., MACÉ, K., AVANTI, O., and PFEIFER, A.M.A. (1996). Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells. Cancer Lett. In Press.
-
(1996)
Cancer Lett.
-
-
Offord, E.A.1
MacÉ, K.2
Avanti, O.3
Pfeifer, A.M.A.4
-
15
-
-
0029101484
-
Rosemary components inhibit benzo(a)pyrene-induced genotoxicity in human bronchial cells
-
OFFORD, E.A., MACÉ, K., RUFFIEUX, C., MALNOË, A., and PFEIFER, A.M.A. (1995). Rosemary components inhibit benzo(a)pyrene-induced genotoxicity in human bronchial cells. Carcinogenesis 16, 2057-2062.
-
(1995)
Carcinogenesis
, vol.16
, pp. 2057-2062
-
-
Offord, E.A.1
MacÉ, K.2
Ruffieux, C.3
Malnoë, A.4
Pfeifer, A.M.A.5
-
16
-
-
0027512246
-
Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6
-
PENMAN, B.W., REECE, J., SMITH, T., YANG, C.S., GELBOIN, H.V., GONZALEZ, F.J., and CRESPI, C.L. (1993). Characterization of a human cell line expressing high levels of cDNA-derived CYP2D6. Pharmacogenetics 3, 28-39.
-
(1993)
Pharmacogenetics
, vol.3
, pp. 28-39
-
-
Penman, B.W.1
Reece, J.2
Smith, T.3
Yang, C.S.4
Gelboin, H.V.5
Gonzalez, F.J.6
Crespi, C.L.7
-
17
-
-
0024805129
-
Cooperation of c-ras-1 and c-myc protooncogenes in the neoplastic transformation of SV40 T-antigen immortalized human bronchial epithelial cells
-
PFEIFER, A., MARK, G.E., MALAN-SHIBLEY, L., GRAZIANO, S.L., AMSTAD, P., and HARRIS, C.C. (1989). Cooperation of c-ras-1 and c-myc protooncogenes in the neoplastic transformation of SV40 T-antigen immortalized human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 86, 10075-10079.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 10075-10079
-
-
Pfeifer, A.1
Mark, G.E.2
Malan-Shibley, L.3
Graziano, S.L.4
Amstad, P.5
Harris, C.C.6
-
18
-
-
0023944920
-
Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate co-precipitation with a plasmid containing SV40 early region genes
-
REDDEL, R.R., KE, Y., GERWIN, B.I., MCMENAMIN, M.G., LECHNER, J.F., SU, R.T., BRASH, D.E., PARK, J.B., RHIM, J.S., and HARRIS, C.C. (1988). Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate co-precipitation with a plasmid containing SV40 early region genes. Cancer Res. 48, 1904-1909.
-
(1988)
Cancer Res.
, vol.48
, pp. 1904-1909
-
-
Reddel, R.R.1
Ke, Y.2
Gerwin, B.I.3
Mcmenamin, M.G.4
Lechner, J.F.5
Su, R.T.6
Brash, D.E.7
Park, J.B.8
Rhim, J.S.9
Harris, C.C.10
-
19
-
-
0022869269
-
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P450s
-
SONG, B.-J., GELBOIN, H.V., PARK, S.-S., YANG, C.S., and GONZALEZ, F.J. (1986). Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P450s. J. Biol. Chem. 261, 16689-16697.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 16689-16697
-
-
Song, B.-J.1
Gelboin, H.V.2
Park, S.-S.3
Yang, C.S.4
Gonzalez, F.J.5
-
20
-
-
0018380453
-
Enumeration of 6-thioguanine-resistant peripheral blood lymphocytes in man as a potential test for somatic cell mutations arising in vivo
-
STRAUSS, G.H., and ALBERTINI, R.J. (1979). Enumeration of 6-thioguanine-resistant peripheral blood lymphocytes in man as a potential test for somatic cell mutations arising in vivo. Mutat. Res. 61, 353-379.
-
(1979)
Mutat. Res.
, vol.61
, pp. 353-379
-
-
Strauss, G.H.1
Albertini, R.J.2
-
21
-
-
0026001618
-
Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochromes P450s
-
WAXMAN, D.J., LAPENSON, D.P., AOYAMA, T., GELBOIN, H.V., GONZALEZ, F.J., and KORZEKWA, K. (1991). Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochromes P450s. Arch. Biochem. Biophys. 290, 100-166.
-
(1991)
Arch. Biochem. Biophys.
, vol.290
, pp. 100-166
-
-
Waxman, D.J.1
Lapenson, D.P.2
Aoyama, T.3
Gelboin, H.V.4
Gonzalez, F.J.5
Korzekwa, K.6
-
22
-
-
0025161416
-
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)
-
WRIGHTON, S.A., BRIAN, W.R., SARI, M.-A., IWASAKI, M., GUENGERICH, F.P., RAUCY, J.L., MOLOWA, D.T., and VANDENBRANDEN, M. (1990). Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol. Pharmacol. 38, 207-213.
-
(1990)
Mol. Pharmacol.
, vol.38
, pp. 207-213
-
-
Wrighton, S.A.1
Brian, W.R.2
Sari, M.-A.3
Iwasaki, M.4
Guengerich, F.P.5
Raucy, J.L.6
Molowa, D.T.7
Vandenbranden, M.8
-
23
-
-
0024400702
-
Identification of a polymorphically expressed member of the human cytochrome P-450III family
-
WRIGHTON, S.A., RING, B.J., WATKINS, P.B., and VANDENBRANDEN, M. (1989). Identification of a polymorphically expressed member of the human cytochrome P-450III family. J. Biol. Chem. 36, 97-105.
-
(1989)
J. Biol. Chem.
, vol.36
, pp. 97-105
-
-
Wrighton, S.A.1
Ring, B.J.2
Watkins, P.B.3
Vandenbranden, M.4
-
24
-
-
0024464027
-
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver
-
YAMANO, S., NHAMBURO, P.T., AOYAMA, T., MEYER, U.A., INABA, T., KALOW, W., GELBOIN, H.V., MCBRIDE, O.W., and GONZALEZ, F.J. (1989). cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: Identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver. Biochemisty 28, 7340-7348.
-
(1989)
Biochemisty
, vol.28
, pp. 7340-7348
-
-
Yamano, S.1
Nhamburo, P.T.2
Aoyama, T.3
Meyer, U.A.4
Inaba, T.5
Kalow, W.6
Gelboin, H.V.7
Mcbride, O.W.8
Gonzalez, F.J.9
-
25
-
-
0025022689
-
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
-
YAMANO, S., TATSUNO, J., and GONZALEZ, F.J. (1990). The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 29, 1322-1329.
-
(1990)
Biochemistry
, vol.29
, pp. 1322-1329
-
-
Yamano, S.1
Tatsuno, J.2
Gonzalez, F.J.3
-
26
-
-
0023877321
-
Metabolism of N-Nitrosodialkylamines by human liver microsomes
-
YOO, J.-S.H., GUENGERICH, F.P., and YANG, C.S. (1988). Metabolism of N-Nitrosodialkylamines by human liver microsomes. Cancer Res. 88, 1499-1504.
-
(1988)
Cancer Res.
, vol.88
, pp. 1499-1504
-
-
Yoo, J.-S.H.1
Guengerich, F.P.2
Yang, C.S.3
|