Effect of inhaled heparin on adenosine-induced bronchial hyperreactivity

International Journal of Clinical Pharmacology and Therapeutics

Volumn 35, Issue 5, 1997, Pages 208-213

  Ceyhan, B B ^a,b   Celikel T ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Adenosine induced bronchial hyperreactivity; Inhaled heparin; Methacholine induced bronchial hyperreactivity

Indexed keywords

ADENOSINE; HEPARIN; METHACHOLINE;

ADOLESCENT; ADULT; AIRWAY CONSTRICTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INHALATION TEST; INHALATIONAL DRUG ADMINISTRATION; MALE; MAST CELL DEGRANULATION; NERVE POTENTIAL; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SINGLE BLIND PROCEDURE;

ADENOSINE; ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; CROSS-OVER STUDIES; FEMALE; FORCED EXPIRATORY VOLUME; HEPARIN; HUMANS; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED;

EID: 0031007257     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ahmed T, Hallmon J, Abraham WM 1991 The effect of heparin on immunologically induced tracheal smooth muscle contraction in allergic sheep. Am Rev Resp Dis 143 (Suppl A360)
2. Ahmed T, Abraham WM, D'brot J 1992 Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am Rev Resp Dis 145: 566-570
3. Ahmed T, Syriste T, Lucio J, Abraham W, Robinson M, D'brot J 1993 Inhibition of antigen induced airway and cutaneous responses by heparin: a pharmacodynamic study. J Appl Physiol 74: 1492-1498
4. Ahmed T, Garrigo J, Danta I 1993 Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med 329: 90-95
5. Block PE, Luscomb M, Marshall SE, Pepper DS, Holbrook JJ 1980 The multiple complexes formed by the interaction of platelet factor 4 with heparin. Biochem J 191: 769-776
6. Boushey HA, Holtzman MJ, Sheller JR, Nadel JA 1980 Bronchial hyperreactivity. Am Rev Respir Dis 121: 389-413
7. Bowler SD, Smith SM, Lavercombe PS 1993 Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am Rev Resp Dis 147: 160-163
8. Ceyhan B, Çelikel T 1995 The effect of inhaled heparin on methacholineinduced bronchial hyperreactivity. Chest 107: 1009-10012
9. Chilvers ER, Challis RA, Willcocks AL, Porter BV, Barnes PJ, Nahorski SR 1990 Characterisation of stereospecific binding sites for inositol 1,4,5-triphosphate in airway smooth muscle. Br J Pharmacol 99: 297-302
10. Coyle AJ, Ackerman SJ, Irvin CG 1993 Cationic proteins induce airway hyperresponsiveness dependent on charge interactions. Am Rev Respir Dis 147: 896-900
11. Crimi N, Palermo F, Oliveri R, Polosa R, Vancheri C, Palermo B, Mistretta A 1990 Tachyphylaxis to repeated challenges with inhaled adenosine in asthmatic subjects. Ann Allergy 65: 134-138
12. Crimi N, Palermo F, Oliveri R, Polosa R, Settinieri I, Mistretta A 1992 Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma. Eur Respir J 5: 560-565
13. Crimi ND, Polosa MD, Magri MD, Armado F, Santanocito MD, Mistretta MD 1995 Attenuation of the airways responsiveness to AMP by inhaled heparin in asthmatic subjects. Am J Respir Crit Care Med 151: A130
14. Cushley MJ, Holgate ST 1985 Adenosine-induced bronchoconstriction in asthma: role of mast cell mediator release. J Allergy Clin Immunol 75: 272-278
15. Daxun Z, Rafferty P, Richards R, Summerell S, Holgate ST 1989 Airway refractoriness to adenosine 5'-monophosphate after repeated inhalation. J Allergy Clin Immunol 83: 152-158
16. Dolowitz DA, Dougherty TF 1965 The use of heparin in the control of allergies. Ann Allergy 23: 309-313
17. Fain JN, Malbon CC 1979 Regulation of adenylate cyclase by adenosine. Mol Cell Biochem 25: 143-169
18. Gh́osh TK, Eis PS, Mullaney JM, Ebert CL, Gill DL 1988 Competitive, reversible, and potent antagonism of inositol 1,4,5-triphosphate-activated calcium release by heparin. J Biol Chem 11075-11079
19. Holtzman MJ, Sheller JR, Dimeo M, Nadel JA, Boushey HA 1980 Effect of ganglionic blockade on bronchial reactivity in atopic subjects. Am Rev Respir Dis 122: 17-25
20. 2-purinoceptor-mediated mechanism. Biochem Pharmacol 33: 3847-3852
21. Irvin CG, Honour JM 1994 Heparin and low molecular weight heparin block the effects of poly-L-Iysine and depress bronchial responsiveness. Am Rev Respir Dis 149: A761
22. Jacques LB 1979 Heparins-anionic polyelectrolyte drugs. Pharmacol Rev 31: 99-166
23. Johnson PRA, Armour CL, Carey D, Black JL 1994 The effect of heparin on human airway smooth muscle growth in culture. Am Rev Respir Dis 149: A300
24. Marquart DL, Walker LL, Wasserman SI 1984 Adenosine receptors on mouse bone marrow derived mast cells; functional significance and regulation by aminophylline. J Immunol 133: 932-937
25. Ng WH, Polosa R, Church MK 1990 Adenosine bronchoconstriction in asthma investigations into its possible mechanisms of asthma. J Clin Pharmacol 30: 89S-98S
26. O'Connor G, Chung KF, Chen-Worsdell YM, Fuller W, Barnes PJ 1991 Effect of inhaled furosemide and bumetanide on adenosine monophosphate-and sodium metabisulfite-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis 143: 1329-1333
27. O'Donnell WJ, Rosenberg MA, Kelleher K, Drazen JM, Israel E 1992 Inhaled heparin does not protect asthmatics against antigen-induced bronchoconstriction. Am Rev Resp Dis 145: A422
28. Oosterhoff Y, Koeter GH, De Monchy JGR, Postma DS 1993 Circadian variation in airway responsiveness to methacholine, propranolol, and AMP in atopic asthmatic subjects. Am Rev Respir Dis 147: 512-517
29. Pauwels RA, Van Derstraeten ME 1987 Animal model for adenosine-induced bronchoconstriction. Am Rev Respir Dis 136: 374-378
30. Pauwels R, Joos G, Van der Straeten M 1988 Bronchial hyperresponsiveness is not bronchial hyperresponsiveness is not bronchial asthma. Clin Allergy 18: 317-321
31. Phillips GD, Rafferty P, Beasley CRW, Holgate ST 1987 The effect of oral terfenadine on the bronchoconstrictor response to inhaled histamine and adenosine-5'-monophosphate in nonatopic asthma. Thorax 42: 939-945
32. Phillips GD, Scott VL, Richards R, Holgate ST 1989 Effect of nedocromil sodium and sodium cromoglycate against bronchoconstriction induced by inhaled adenosine-5'-monophosphate. Eur Respir J 2: 210-217
33. y-monophosphate and allergen in atopic nonasthmatic subjects. Am Rev Respir Dis 141: 9-13
34. Polosa R, Holgate ST, Church MK 1989 Adenosine as a pro-inflammatory mediator in asthma. Pulm Pharmacol 2: 21-26
35. Polosa R, Rajakulasingam K, Church MK, Holgate ST 1992 Repeated inhalation of bradykinin attenuates adenosine 5'-monphosphate (AMP) induced bronchoconstriction in asthmatic airways. Eur Respir J 5: 700-706
36. Schwartz LB, Bradford TRB 1986 Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer. J Biol Chem 261: 7372-7379