End-capped antisense oligodeoxynucleotides effectively inhibit gene expression in vivo and offer a low-toxicity alternative to fully modified phosphorothioate oligodeoxynucleotides

Molecular Brain Research

Volumn 47, Issue 1-2, 1997, Pages 223-228

  Hebb, M O ^a   Robertson, H A ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Antisense oligodeoxynucleotide; End capped phosphorothioate; Gene suppression; Nuclease resistance

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCLING BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; DRUG SPECIFICITY; GENE EXPRESSION REGULATION; GENE REPRESSION; IMMEDIATE EARLY GENE; IMMUNOHISTOCHEMISTRY; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BEHAVIOR, ANIMAL; CORPUS STRIATUM; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031007054     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00048-X     Document Type: Article

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