Structure of mescengricin, a novel neuronal cell protecting substance produced by Streptomyces griseoflavus

Tetrahedron Letters

Volumn 38, Issue 19, 1997, Pages 3431-3434

  Kim, Jung Sik ^a   Shin Ya, Kazuo ^a   Furihata, Kazuo ^b   Hayakawa, Yoichi ^a   Seto, Haruo ^a  

^a Institute of Molecular and Cellular Biosciences   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; GLUTAMIC ACID; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CHICKEN; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY; STREPTOMYCES;

EID: 0031006726     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00638-2     Document Type: Article

References (13)

1. Choi, D. W. J. Neurosci., 1990, 10, 2493-2501.
2. Coyle, J. T.; Puttfarcken, P. Science, 1993, 262, 689-695.
3. Yamamoto, T.; Taguchi, T. Neurosci. Lett., 1992, 139, 205-208 and references cited therein.
4. max nm (ε); 210 (10,500), 256 (5,200), 284 (6,400) and 400 (4,500) in MeOH; 238 (10,000) and 410 (4,800) in 0.01 N NaOH-MeOH.
5. 6 at 125 MHz): 149.1 (C-2), 112.8 (C-3), 131.6 (C-4), 111.7 (C-4a), 111.9 (C-4b), 126.0 (C-5), 110.1 (C-6), 157.9 (C-7), 96.8 (C-8), 141.4 (C-8a), 147.4 (C-9a), 95.8 (C-10), 165.9 (C-11), 71.0 (C-12), 38.4 (C-13), 181.1 (C-14), 20.6 (C-15), 167.1 (C-16), 68.0 (C-17), 70.6 (C-18), 63.9 (C-19).
6. 6 at 125 MHz): 148.4 (C-2), 112.4 (C-3), 134.0 (C-4), 112.2(C-4a), 112.0 (C-4b), 126.2 (C-5), 110.3 (C-6), 157.9 (C-7), 96.8 (C-8), 141.0 (C-8a), 146.3 (C-9a), 95.4 (C-10), 165.7 (C-11), 70.0 (C-12), 38.1 (C-13), 181.8(C-14), 20.2 (C-15), 167.6 (C-16).
7. Furihata, K.; Seto, H. Tetrahedron Lett., 1995, 36, 2817-2820.
8. Budavari, S.; O'Neil, M. J.; Heckelman, P. E.; Kinneary, J. F. The Merck Index; Merck & Co., Inc.: New Jersey, 1996; pp. 889-890.
9. 1 did not protect N18-RE-105 cells from L-glutamate toxicity at the concentration of 20 nM.
10. Malouf, A. T.; Schnaar, R. L.; Coyle, J. T. J. Biol. Chem., 1984, 20, 12756-12762.
11. Shin-ya, K.; Tanaka, M.; Furihata K.; Hayakawa Y.; Seto, H. Tetrahedron Lett., 1993, 34, 4943-4944.
12. Shin-ya, K.; Shmizu, S.; Kunigami, T.; Furihata K.; Furihata K.; Hayakawa Y.; Seto, H. J. Antibiotics, 1995, 48, 574-578.
13. Shin-ya, K.; Shmizu, S.; Kunigami, T.; Furihata K.; Hayakawa Y.; Seto, H. J. Antibiotics, 1995, 48, 1378-1381.