A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient

Alcoholism: Clinical and Experimental Research

Volumn 21, Issue 4, 1997, Pages 576-580

  Wang, James J L ^a   Martin, Peter R ^a,b   Singleton, Charles K ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Protein Assembly; Transketolase; Wernicke Korsakoff Syndrome

Indexed keywords

THIAMINE; TRANSKETOLASE;

ALCOHOL ABUSE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; THIAMINE DEFICIENCY; WERNICKE KORSAKOFF SYNDROME;

ESCHERICHIA COLI;

EID: 0031006714     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1997.tb03805.x     Document Type: Article

References (27)

1. Wilson JD: Vitamin Deficiency and Excess. Philadelphia, McGraw-Hill, 1991
2. Tanphaichitr V: Thiamine. New York, Lea and Febiger, 1994
3. Gibson GE, Nielsen P, Mykytyn V, Carlson K, Blass JP: Regionally selective alterations in enzymatic activities and metabloic fluxes during thiamin deficiency. Neurochem Res 14:17-24, 1989
4. Butterworth RF, Heroux M: Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acid and thiamine dependent enzymes. J Neurochem 52:1079-1084, 1989
5. Butterworth RF, Kril J, Harper C: Thiamine-dependent enzyme changes in the brains of alcoholics: Relationship to the Wernicke-Korsakoff syndrome. Alcohol Clin Exp Res 16:634-639, 1993
6. Heroux M, Butterworth RF: Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy. Neurochem Res 20:87-93, 1995
7. Butterworth RF: Effects of thiamine deficiency on brain metabolism implications for the pathogenesis of the Wernicke-Korsakoff syndrome. Alcohol Alcohol 24:271-279, 1989
8. Blass JP, Gibson GE: Abnormality of a thiamine requiring enzyme in patients with Wernicke-Korsakoff syndrome. N Engl J Med 297:1367-1370, 1977
9. Mukherjee AB, Svoronos S, Ghazanfari A, Martin PR, Fisher A, Roecklein B, Rodbard D, Staton R, Behar D, Berg CJ, Manjunath R: Transketolase abnormality in cultured fibroblasts from familial chronic alcoholic men and their male offspring. J Clin Invest 79:1039-1043, 1987
10. Nixon PF, Kaczmarek MJ, Tate J, Kerr RA, Price J: An erythrocyte transketolase isoenzyme pattern associated with the Wernicke-Korsakoff syndrome. Eur J Clin Invest 14:278-281, 1984
11. McCool BA, Plonk SG, Martin PR, Singleton CK: Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. J Biol Chem 268:1397-1404, 1993
12. Singleton CK, Pekovich SR, McCool BA, Martin PR: Hysteretic behavior of human transketolase: Implications for thiamine deficiency. J Nutr 125:189-194, 1995
13. Blanjaar BA, Zwang R, Blijenberg BG: No transketolase abnormalities in Wernicke-Korsakoff patients. J Neurol Sci 106:88-90, 1991
14. Tale JR, Nixon PF: Measurement of Michaelis constant for human erythrocyte transketolase and thiamine diphosphate. Anal Biochem 160:78-87, 1987
15. Egan RM, Sable HZ: Transketolase kinetics: The slow reconstitution of the holoenzyme is due to rate -limiting dimerization of the subunits. J Biol Chem 256:4877-4883, 1981
16. Booth CK, Nixon PF: Reconstitution of holotransketolase is by a thiamine-diphosphate-magnesium complex. Eur J Biochem 218:261-265, 1993
17. Wang J-L, Martin PR, Singleton CK: Aspartate 155 of human transketolase is essential for thiamine pyrophosphate-magnesium binding, and cofactor binding is required for dimer formation. Biochem Biophys Acta (in press)
18. Pekovich SR, Martin PR, Singleton CK: Thiamine pyrophosphate-requiring enzymes are altered during pyrithiamine-induced thiamine deficiency in cultured human lymphoblasts. J Nutr 126:1791-1798, 1995
19. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. Washington, D.C., American Psychiatric Association, 1987
20. Welch LW, Cunningham AT, Echardt MJ, Martin PR: Fine motor speed deficits in alcoholic Korsakoff's syndrome. Alcohol Clin Exp Res (in press), 1997
21. Neet KE, Ainslie GR Jr: Hysteretic enzymes. Methods Enzymol 64:192-226, 1980
22. Singleton CK, Wang JJ-L, Shen L, Martin PR: Conserved residues are functionally distinct within transketolases of different species. Biochemistry 49:15865-15869, 1996
23. Hames BD, Rickwood D: Gel Electrophoresis of Proteins. Oxford, UK, IRL Press, 1990
24. Hawkins CF, Borges A, Perham RN: A common structural motif in thiamine pyrophosphate-binding enzymes. FEBS Lett 255:77-82, 1989
25. Jeyasingham MD, Pratt OE: Rat brain apotransketolase: Activation and inactivation. J Neurochem 50:1537-1541, 1988
26. Tzagoloff A, Jang J, Glerum DM, Wu M: FLX1 codes for a carrier protein involved in maintaining a proper balance of flavin nucleotides in yeast mitochondria. J Biol Chem 271:7392-7397, 1996
27. Ross NS, Hansen TPB: Riboflavin deficiency is associated with selective preservation of critical flavoenzyme-dependent metabolic pathways. BioFactors 3:185-190, 1992