The anti-FcγRIII mAb 3G8 induces neutrophil activation via a cooperative action of FcγRIIIb and FcγRIIa

International Journal of Biochemistry and Cell Biology

Volumn 29, Issue 3, 1997, Pages 465-473

  Vossebeld, Paula J M ^a   Homburg, Christa H E ^a   Roos, Dirk ^a   Verhoeven, Arthur J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

CD16; CD32; Fc receptor; Granulocytes; Signal transduction

Indexed keywords

FC RECEPTOR; MONOCLONAL ANTIBODY; RECEPTOR SUBTYPE;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HUMAN; LEUKOCYTE ACTIVATION; NORMAL HUMAN;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CALCIUM; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; NEUTROPHILS; RECEPTORS, IGG; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0031006064     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(96)00160-4     Document Type: Article

References (30)

1. 2+ influx: analysis with indo-1. Biochem. Biophys. Res. Commun. 137, 500-506.
2. Buyon J. P., Abramson S. B., Philips M. R., Slade S. G., Ross G. D., Weissmann G. and Winchester R. J. (1988) Dissociation between increased surface expression of Gp165/95 and homotypic neutrophil aggregation. J. Immunol. 140, 3156-3160.
3. Buyon J. P., Slade S. G., Perdue R. A. and Winchester R. J. (1989) CD11b/CD18-dependent homotypic neutrophil aggregation: evidence for discrete adhesiotopes and activation of the molecule. In Leucocyte Typing IV. White Cell Differentiation Antigens (Edited by Knapp W., Dörken B., Gilks W. R.. et al.), pp. 560-562. Oxford University Press, New York.
4. Connelly P. A., Farrell C. A., Merenda J. M., Conklyn M. J. and Showell H. J. (1991) Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3). Biochem. Biophys. Res. Commun. 177, 192-201.
5. 2+ influx in human neutrophils. Biochem. J. 297, 595-601.
6. 2+ dependence of human Fcγ receptor-initiated phagocytosis. J. Biol. Chem. 270, 22301-22307.
7. Edberg J. C. and Kimberly R. P. (1994) Modulation of Fcγ and complement receptor function by the glycosyl-phosphatidylinositol-anchored form of FcγRIII. J. Immunol. 152, 5826-5835.
8. Fleit H. B., Wright S. D. and Unkeless J. C. (1982) Human neutrophil Fcγ receptor distribution and structure. Proc. Natl. Acad. Sci. U.S.A. 79, 3275-3279.
9. Fleit H. B., Kuhnle M. and Kobasiuk C. D. (1989) Monoclonal antibodies to CD16 detect antigenic differences in FcγRIII on neutrophils and natural killer cells. In Leucocyte Typing IV. White Cell Differentiation Antigens (Edited by Knapp W., Dörken B., Gilks W. R., et al.), pp. 579-581. Oxford University Press, New York.
10. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
11. Hsieh Ma S. T., Eaton A. M., Shi T. and Ring D. B. (1992) In vitro cytotoxic targeting by human mononuclear cells and bispecific antibody 2B1, recognizing c-erbB-2 protooncogene product and Fcγ receptor III. Cancer Res. 52, 6832-6839.
12. Huizinga T. W. J., Van der School C. E., Jost C., Klaassen R., Kleijer M., Von dem Borne A. E. G. Kr, Roos D. and Tetteroo P. A. (1988) The PI-linked receptor FcRIII is released on stimulation of neutrophils. Nature 333, 667-669.
13. Huizinga T. W. J., Kerst M., Nuyens J. H., Vlug A., Von dem Borne A. E. G. Kr, Roos D. and Tetteroo P. A. (1989) Binding characteristics of dimeric IgG subclass complexes to human neutrophils. J. Immunol. 142, 2359-2364.
14. Hundt M. and Schmidt R. E. (1992) The glycosylphosphatidylinositol-linked Fcγ receptor III represents the dominant receptor structure for immune complex activation of neutrophils. Eur. J. Immunol. 22, 811-816.
15. PMN mediates transmembrane signaling events distinct from FcγRII. J. Exp. Med. 171, 1239-1255.
16. 2+-independent route. J. Immunol. 142, 623-628.
17. Kurlander R. J. (1983) Blockade of Fc receptor-mediated binding to U937 cells by murine monoclonal antibodies directed against a variety of surface antigens. J. Immunol. 131, 140-145.
18. Kuypers T. W., Koenderman L., Weening R. S., Verhoeven A. J. and Roos D. (1990) Continuous cell activation is necessary for stable interaction of complement receptor type 3 with its counter-structure in the aggregation response of human neutrophils. Eur. J. Immunol. 20, 501-508.
19. Putney J. W. Jr. (1990) Capacitative calcium entry revisited. Cell Calcium. 11, 611-624.
20. Reumaux D., Vossebeld P. J. M., Roos D. and Verhoeven A. J. (1995) Effect of TNF-induced integrin activation on Fcγ receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies. Blood, in press.
21. Robinson J. J., Watson F., Bucknall R. C. and Edwards S. W. (1994) Role of Fc γ receptors in the activation of neutrophils by soluble and insoluble immunoglobulin aggregates isolated from the synovial fluid of patients with rheumatoid arthritis. Ann. Rheum. Dis. 53, 515-520.
22. Rosenfeld S. I., Looney R. J., Leddy J. P., Phipps D. C., Abraham G. N. and Anderson C. L. (1985) Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes. J. Clin. Invest. 76, 2317-2322.
23. Salmon J. E., Millard S. S., Brogle N. L. and Kimberly R. P. (1995) Fcγ receptor IIIb enhances Fcγ receptor IIa function in an oxidant-dependent and allele-sensitive manner. J. Clin. Invest. 95, 2877-2885.
24. Shi T., Eaton A. M. and Ring D. B. (1991) Selection of hybrid hybridomas by flow cytometry using a new combination of fluorescent vital stains. J. Immunol. Meth. 141, 165-175.
25. Stöckl J., Majdic O., Pickl W. F., Rosenkranz A., Prager E., Gschwantler E. and Knapp W. (1995) Granulocyte activation via a binding site near the C-terminal region of complement receptor type 3 α-chain (CD11b) potentially involved in intramembrane complex formation with glycosylphosphatidylinositol-anchored FcγRIIIB (CD16) molecules. J. Immunol. 154, 5452-5463.
26. Tax W. J., Willems H. W., Reekers P. P., Capel P. J. and Koene R. A. (1983) Polymorphism in mitogenic effect of IgG1 monoclonal antibodies against T3 antigen on human T cells. Nature 304, 445-447.
27. Van de Winkel J. G. J. and Capel P. J. (1993) Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today 14, 215-221.
28. 2+ response in human neutrophils. J. Biol. Chem. 270, 10671-10679.
29. Weiner L. M., Holmes M., Richeson A., Godwin A., Adams G. P., Hsieh Ma S. T., Ring D. B. and Alpaugh R. K. (1993) Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1. J. Immunol. 151, 2877-2886.
30. Werner G., Von dem Borne A. E. G. Kr., Bos M. J. E., Tromp J. F., Van der Plas-Van Dalen C. M., Visser F. J., Engelfriet C. P. and Tetteroo P. A. T. (1985) Localization of the human NA1 alloantigen on neutrophil Fcγ receptors. In Leucocyte Typing II. White Cell Differentiation Antigens (Edited by Reinherz E. L., Haynes B. F., Nadler L. M., and Bernstein I. D.), pp. 109-121. Springler-Verlag, New York.