Pathogenesis of inflammatory bowel disease

Digestion

Volumn 58, Issue , 1997, Pages 59-61

  Zeitz, Martin ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Crohn s disease; Gut associated lymphoid tissue; Inflammatory bowel disease; Pathogenesis; Ulcerative colitis Immunology

Indexed keywords

CONFERENCE PAPER; CROHN DISEASE; ENTERITIS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOLOGY; INTESTINE MUCOSA; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOID TISSUE; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; ULCERATIVE COLITIS;

ANIMALS; HUMANS; IMMUNITY, MUCOSAL; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0031006007     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000201529     Document Type: Article

References (25)

1. Zeitz M: Immunorcgulatory abnormalities in infiammatory bowel disease. Eur J Gastroentero Hepatol 1990:2:246-250.
2. Strober W, James SP: The immunologic basis of infiammatory bowel disease. J Clin Immunol 1986:6:415-432.
3. MacDermott RP: Alterations in the mucosal immune system in ulcerative colitis and Crohn's disease. Med Clin North Ant 1994:78:1207-1231.
4. Pabst R: The anatomical basis for the immune function of the gut. Anal Embryol 1987:176: 135-144.
5. Zeitz M, James SP, Strober W: Die Funktion des gastrointestinalen Immunsystems in der Abwehr enteropathogener Bakterien. 7 Gastroenterol 1986:24(suppl 3):43-52.
6. Zeitz M, Schieferdecker I H, James SP, Riecken EO: Special functional features of T-lympho-cvte subpopulations in the elTcctor compartment of the intestinal mucosa and their relation to mucosal transformation. Digestion 1990; 46(suppl 2):280-289.
7. Bland PW, Warren LG: Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. Immunology 1986:58:9-14.
8. Mayer L, Shlien R: Evidence for function of la molecules on gut epithelial cells in man. J Exp Med 1987:166:1471-1483.
9. Mosmann TR. Coffman RL: Th 1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989:7:145-173.
10. Zeitz M, Ullrich R, Schieferdecker HE, Weiss-Breckwoldt AN, James SP, Riecken EO: Characterization of T cell subpopulations in the intestinal lamina propria in infiammatory bowel disease: in Goebell H. Ewe K, Malchow' H. Koelbcl C (eds): Inflammatory Bowel Diseases: Progress in Basic Research and Clinical Implications. Lancaster. Kluwer Academic. 1991. pp 63-70.
11. Schreiber S, MacDermott RP, Raedler A, Pinnau R, Bertovich MJ, Nash GS: Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease. Gastroenterology 1991:101:1020-1030.
12. Schieferdecker HL, Ullrich R, Hirseland H, Zeitz M: T ceil differentiation antigens on lymphocytes in the human intestinal lamina propria. J Immunol 1992;149:2816-2822.
13. Zeitz M, Quinn TC, Graelf AS, James SP: Mucosal T cells provide helper function but do not proliferate when stimulated by specific antigen in lymphogranuloma venereum proctitis in non-human primates. Gastroenterology 1988:94: 353-366.
14. Qiao L, Schürntann G, Betzler M, Mcucr SC: Activation and signaling status of human lamina propria T lymphocytes. Gastroenterology 1991:101:1529-1536.
15. Zeitz M, Schieferdecker HL, Ullrich R, James SP, Riecken EO: Phenotype and function of lamina propria T lymphocytes. Immunol Res 1991;10:199-206.
16. Pirzer U, Schönhaar A, Fleischer B, Hermann E, Meyer zum Büschenfelde KH: Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 1991:338:1238-1239.
17. Qiao L, Golling M, Autschbach F, Schurmann G, Meuer SC: T cell receptor repertoire and mitotic responses of lamina propria T lymphocytes in inflammatory bowel disease. Clin Exp Immunol 1994:97:303-308.
18. Duehmann R, Kaiser I, Hermann F, Mayel W, Ewe K, Meyer zum Büschenfelde KH: Tolerance exists towards intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995:102:448-455.
19. Mayer L, Eisenhardt D: Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. J Clin Invest 1990:86:1255-1260.
20. Kühn R, Löliler J, Rennick D, Rajewsky K, Müller W: Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993:75:263-274.
21. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I: Ulcerative colitis-like disease in mice with a disrupted inierleukin-2 gene. Cell 1993:75:253-261.
22. Kündig TM, Schorle LI, Bachmann MF, Hengartner H, Zinkernagel RM, Horak I: Immune responses in interleukin-2-deficient mice. Science 1993:262:1059-1061.
23. Monibacrts P, Mizoguchi E, Grusby MJ, Glimchcr LIT, Bhan AK, Tonegawa S: Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993: 75:274-282.
24. Mullin GE: Implications for T-cell lymphokine production patterns in mucosal disease. Mucosal Immunol Update 1994:2:9-12.
25. Breese E, Braegger CP, Corrigan CJ, Walker-Smith JA, MacDonald TT: Interleukin-2- and interferon-y-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993:78:127-131.