Systemic administration of insulin-like growth factor I (IGF-I) causes growth of the rat prostate

Journal of Urology

Volumn 158, Issue 1, 1997, Pages 222-227

  Tørring, Niels ^a   Vinter Jensen, Lars ^b   Pedersen, Steen Bønløkke ^b   Sørensen, Flemming Brandt ^b   Flyvbjerg, Allan ^b   Nexø, Ebba ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

Epidermal growth factor; Insulin like growth factor I; Ornithine decarboxylase; Prostate; Rats

Indexed keywords

EFLORNITHINE; EPIDERMAL GROWTH FACTOR; ORNITHINE DECARBOXYLASE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RAT; SEMINAL VESICLE;

EID: 0031005918     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-199707000-00075     Document Type: Article

References (35)

1. Butler, W. W. S. and Schade, A. L.: The effects of castration and androgen replacement on the nucleic acid composition, metabolism, and enzymatic capacities of the rat ventral prostate. Endocrinology, 63: 271, 1958.
2. George, F. W., Johnson, L. and Wilson, J. D.: The effect of a 5 alpha-reductase inhibitor on androgen physiology in the immature male rat. Endocrinology, 125: 2434, 1989.
3. Cunha, G. R., Donjacour, A. A., Cooke, P. S., Mee, S., Bigsby, R. M., Higgins, S. J. and Sugimura, Y.: The endocrinology and developmental biology of the prostate. Endocr. Rev., 8: 338, 1987.
4. Davies, P. and Eaton, C. L.: Regulation of prostate growth. J. Endocrinol., 131: 5, 1991.
5. Nishi, N., Matuo, Y., Nakamoto, T. and Wada, F.: Proliferation of epithelial cells derived from rat dorsolateral prostate in serum-free primary cell culture and their response to androgen. In. Vitro. Cell. Dev. Biol., 24: 778, 1988.
6. McKeehan, W. L., Adams, P. S. and Rosser, M. P.: Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture. Cancer Res., 44: 1998, 1984.
7. Hayward, S. W., Del Buono, R., Deshpande, N. and Hall, P. A.: A functional model of adult human prostate epithelium. The role of androgens and stroma in architectural organisation and the maintenance of differentiated secretory function. J. Cell. Sci., 102: 361, 1992.
8. Nishi, N., Shimizu, C., Okutani, T., Kagawa, Y., Takasuga, H., Suno, M. and Wada, F.: Rat prostatic growth factors: purification and characterization of high and low molecular weight epidermal growth factors from rat dorsolateral prostate. Biochim. Biophys. Acta, 1095: 268, 1991.
9. Atfi, A., Samperez, S. and Jouan, P.: Secretion of transforming growth factor-beta by the immature rat prostate. Prostate, 24: 149, 1994.
10. Jacobs, S. C., Story, M. T., Sasse, J. and Lawson, R. K.: Characterization of growth factors derived from the rat ventral prostate. J. Urol., 139: 1106, 1988.
11. Reiter, E., Bonnet, P., Sente, B., Dombrowicz, D., de Leval, J., Closset, J. and Hennen, G.: Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats. Mol. Cell. Endocrinol., 88: 77, 1992.
12. Cohen, P., Peehl, D. M., Lamson, G. and Rosenfeld, R. G.: Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. J. Clin. Endocrinol. Metab., 73: 401, 1991.
13. Fiorelli, G., De Bellis, A., Longo, A., Giannini, S., Natali, A., Costantini, A., Vannelli, G. B. and Serio, M.: Insulin-like growth factor-I receptors in human hyperplastic prostate tissue: characterization, tissue localization, and their modulation by chronic treatment with a gonadotropin-releasing hormone analog. J. Clin. Endocrinol. Metab., 72: 740, 1991.
14. Reiter, E., Kecha, O., Hennuy, B., Lardinois, S., Klug, M., Bruyninx, M., Closset, J. and Hennen, G.: Growth hormone directly affects the function of the different lobes of the rat prostate. Endocrinology, 136: 3338, 1995.
15. St. Arnaud, R., Poyet, P., Walker, P. and Labrie, F.: Androgens modulate epidermal growth factor receptor levels in the rat ventral prostate. Mol. Cell. Endocrinol., 56: 21, 1988.
16. Taylor, T. B. and Ramsdell, J. S.: Transforming growth factor-alpha and its receptor are expressed in the epithelium of the rat prostate gland. Endocrinology, 133: 1306, 1993.
17. Wu, H. H., Kawamata, H., Kawai, K, Lee, C. and Oyasu, R.: Immunohistochemical localization of epidermal growth factor and transforming growth factor alpha in the male rat accessory sex organs. J. Urol., 150: 990, 1993.
18. Jacobs, S. C. and Story, M. T.: Exocrine secretion of epidermal growth factor by the rat prostate: effect of adrenergic agents, cholinergic agents, and vasoactive intestinal peptide. Prostate, 13: 79, 1988.
19. Hiramatsu, M., Kashimata, M., Minami, N., Sato, A. and Murayama, M.: Androgenic regulation of epidermal growth factor in the mouse ventral prostate. Biochem. Int., 17: 311, 1988.
20. Marengo, S. R. and Chung, L. W.: An orthotopic model for the study of growth factors in the ventral prostate of the rat: effects of epidermal growth factor and basic fibroblast growth factor. J. Androl., 15: 277, 1994.
21. Müller, M., Bernstein, H. G., Pajunen, A., Järvinen, M. and Dorn, A.: Immunohistochemical demonstration of ornithine decarboxylase in tissues. A preliminary study. Acta Histochem. Suppl., 33: 197, 1986.
22. Rui, H., Brekke, I., Mørkas, L. and Purvis, K.: Androgen interaction with the polyamine system of the rat prostate. Andrologia, 19: 134, 1987.
23. Crozat, A., Palvimo, J. J., Julkunen, M. and Janne, O. A.: Comparison of androgen regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase gene expression in rodent kidney and accessory sex organs. Endocrinology, 130: 1131, 1992.
24. Gundersen, H. J., Bendtsen, T. F., Korbo, L., Marcussen, N., Møller, A., Nielsen, K., Nyengaard, J. R., Pakkenberg, B., Sørensen, F. B., Vesterby, A. and West, M.: Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS., 96: 379, 1988.
25. Pedersen, S. B., Flyvbjerg, A., Grønbæk, H. and Richelsen, B.: Increased ornithine decarboxylase activity in kidneys undergoing hypertrophy in experimental diabetes. Mol. Cell. Endocrinol., 86: 67, 1992.
26. Flyvbjerg, A., Frystyk, J., Østerby, R. and Ørskov, H.: Kidney IGF-I and renal hypertrophy in GH-deficient diabetic dwarf rats. Am. J. Physiol., 262: E956, 1992.
27. Frystyk, J., Vinter-Jensen, L., Skjærbsek, C. and Flyvbjerg, A.: The effect of epidermal growth factor on circulating levels of free and total IGF-I and IGF-binding proteins in adult rats. Growth Regul., 6: 48, 1996.
28. Pinski, J., Reile, H., Halmos, G., Groot, K. and Schally, A. V.: Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer. Int. J. Cancer., 59: 51, 1994.
29. Cohen, P., Peehl, D. M., Baker, B., Liu, F., Hintz, R. L. and Rosenfeld, R. G.: Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia. J. Clin. Endocrinol. Metab., 79: 1410, 1994.
30. Boudon, C., Rodier, G., Lechevallier, E., Mottet, N., Barenton, B. and Sultan, C.: Secretion of insulin-like growth factors and their binding proteins by human normal and hyperplastic prostatic cells in primary culture. J. Clin. Endocrinol. Metabol., 81: 612, 1996.
31. Kimura, G., Kasuya, J., Giannini, S., Honda, Y., Mohan, S., Kawachi, M. H., Akimoto, M. and Fujita-Yamaguchi, Y.: Insulin-like growth factor (IGF) system components in human prostatic cancer cell lines: LNCaP, DU145, and PC-3 cells. Int. J. Urol., 3: 39, 1996.
32. George, F. W., Russell, D. W. and Wilson, J. D.: Feed-forward control of prostate growth: dihydrotestosterone induces expression of its own biosynthetic enzyme, steroid 5 alpha-reductase. Proc. Natl. Acad. Sei. USA, 88: 8044, 1991.
33. Horton, R., Pasupuletti, V. and Antonipillai, I.: Androgen induction of steroid 5 alpha-reductase may be mediated via insulin-like growth factor-I. Endocrinology, 133: 447, 1993.
34. Hsueh, A. J., Welsh, T. H. and Jones, P. B.: Inhibition of ovarian and testicular steroidogenesis by epidermal growth factor. Endocrinology, 108: 2002, 1981.
35. Welsh, T. H. and Hsueh, A. J.: Mechanism of the inhibitory action of epidermal growth factor and testicular androgen biosynthesis in vitro. Endocrinology, 110: 1498, 1982.