Cisplatin, mitomycin, and vindesine followed by intraoperative and postoperative radiotherapy for stage III non-small cell lung cancer: Final results of a Phase II study

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 20, Issue 3, 1997, Pages 276-281

  Aristu, Javier ^a   Rebollo, José ^a   Martínez Monge, Rafael ^b   Aramendía, Jose M ^a   Viera, Juan C ^b   Azinovic, Ignacio ^b   Herreros, Jesús ^a   Brugarolas, Antonio ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b Clin Universitaria de Navarra ^*

Author keywords

Complete pathologic response; Neoadjuvant chemotherapy; Non small cell lung cancer; Resectability; Survival

Indexed keywords

CISPLATIN; DEXAMETHASONE; DEXCHLORPHENIRAMINE; METOCLOPRAMIDE; MITOMYCIN; VINDESINE;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEARING LOSS; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROTOXICITY; PERIPHERAL NEUROPATHY; PEROPERATIVE CARE; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE CARE; SURVIVAL RATE; TREATMENT OUTCOME; VOMITING;

ADULT; AGED; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CHEMOTHERAPY, ADJUVANT; CISPLATIN; FEMALE; HUMANS; INTRAOPERATIVE CARE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MITOMYCINS; NEOPLASM STAGING; POSTOPERATIVE CARE; RADIOTHERAPY, ADJUVANT; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VINDESINE;

EID: 0031005545     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-199706000-00014     Document Type: Article

References (29)

1. Holmes EC. Surgical adjuvant therapy of non-small-cell lung cancer. J Surg Oncol 1989;42(suppl 1):26-33.
2. Mountain CF. Assessment of the role of surgery for the control of lung cancer. Ann Thorac Surg 1977;24:365-73.
3. Perez CA, Pajak TF, Rubin P, et al. Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy. Cancer 1987;59:1874-81.
4. 369.6 Gy in favorable patients with radiation therapy oncology stage III non-small-cell lung carcinoma. Report of Radiation Therapy Oncology Group 83-11. J Clin Oncol 1990;8:1543-55.
5. Byhardt RW, Pajak TF, Emami B, Herskovic A, Dogget S, Olsen LA. A phase I/II study to evaluate accelerated fractionation via concomitant boost for squamous, adeno, and large cell carcinoma of the lung. Report of Radiation Therapy Oncology Group 84-07. Int J Radiat Oncol Biol Phys 1993;26: 459-68.
6. Schaake-Koning C, Van Den Bogaert W, Dalesio O, et al. Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer. N Engl J Med 1992;326:524-30.
7. Dillman RO, Seagren SL, Propert KL, et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N Engl J Med 1990;323:940-5.
8. Martini N. Surgical treatment of lung cancer. Semin Oncol 1990; 17(suppl 7):9-10.
9. Martini N, Kris MG, Gralla RJ, et al. The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2MO). Ann Thorac Surg 1988;45:370-9.
10. Kris MG, Gralla RJ, Wertheim MS, et al. Trial of the combination of mitomycin, vindesine, and cisplatin in patients with advanced non-small cell lung cancer. Cancer Treat Rep 1986;70:1091-6.
11. Martini N, Kris MG, Flehinger BJ, et al. Preoperative chemotherapy for stage IIIa (N2) lung cancer. The Sloan-Kettering experience with 136 patients. Ann Thorac Surg 1993;55:1365-74.
12. Burkes RL, Ginsberg RJ, Shepherd FA, et al. Induction chemotherapy with mitomycin, vindesine, and cisplatin for stage III unresectable non-small-cell lung cancer; results of the Toronto phase II trial. J Clin Oncol 1992;10:580-6.
13. Fukuoka M, Masuda N, Furuse K, et al. A randomized trial in inoperable non-small-cell lung cancer, vindesine and cisplatin versus mitomycin, vindesine, and cisplatin versus etoposide and cisplatin alternating with vindesine and mitomycin. J Clin Oncol 1991;9:606-13.
14. Spain RC. Neoadjuvant mitomycin C, cisplatin, and infusion vinblastine in locally and regionally advanced non-small cell lung cancer; problems and progress from the perspective of long-term follow-up. Semin Oncol 1988; 15(suppl 4):6-15.
15. Pass HI, Pogrebniak HW, Steinberg SM, Mulshine J, Minna J. Randomized trial of neoadjuvant therapy for lung cancer; interim analysis. Ann Thorac Surg 1992;53:992-8.
16. Bitran JD, Golomb HM, Hoffman PC, et al. Protochemotherapy in non-small cell lung carcinoma. An attempt to increase surgical resectability and survival. A preliminary report. Cancer 1986;57:44-53.
17. Taylor SG IV, Trybula M, Bonomi PD, et al. Simultaneous cisplatin fluorouracil infusion and radiation followed by surgical resection in regionally localized stage III, non-small cell lung cancer. Ann Thorac Surg 1987;43:87-91.
18. Strauss GM, Herndon JE, Sherman DD, et al. Neoadjuvant chemotherapy and radiotherapy followed by surgery in stage IIIA non-small cell carcinoma of the lung; report of a cancer and leukemia group B phase II study. J Clin Oncol 1992;10: 1237-44.
19. Eagan RT, Ruud C, Lee RE, Pairolero PC, Gail MH. Pilot study of induction therapy with ciclophosphamide, doxorubicin, and cisplatin (CAP) and chest irradiation prior to thoracotomy in initially inoperable stage III M0 non-small cell lung cancer. Cancer Treat Rep 1987;71:895-900.
20. Rusch VW, Albain KS, Crowley JJ, et al. Surgical resection of stage IIIA and stage IIIB non-small-cell lung cancer after concurrent induction chemoradiotherapy. J Thorac Cardiovasc Surg 1993;105:97-106.
21. Weiden PL, Piantadosi S. Preoperative chemotherapy (cisplatin and fluorouracil) and radiation therapy in stage III non-small-cell lung cancer; a phase II study of the Lung Cancer Study Group. J Natl Cancer Inst 1991;83:266-72.
22. Rosell R, Gómez-Codina J, Camps C, et al. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl J Med 1994;330:153-8.
23. Pisters MW, Kris MG, Gralla RJ, Zaman M, Heelan RT, Martini N. Pathologic complete response in advanced non-small-cell lung cancer following preoperative chemotherapy; implications for the design of future non-small-cell lung cancer combined modality trials. J Clin Oncol 1993;11:1757-62.
24. Mountain CF. A new international staging system for lung cancer. Chest 1986;89(suppl);225-33.
25. Calvo FA, Ortiz De Urbina D, Abuchaibe O, et al. Intraoperative radiotherapy during lung cancer surgery; technical description and early clinical results. Int J Radiat Oncol Biol Phys 1990;19;103-9.
26. Calvo FA, Ortiz De Urbina D, Herreros J, Lloreus R. Lung cancer. In: Calvo FA, Santos M, Brady LW, eds. Intraoperative radiotherapy. Clinical results. Berlin: Springer Verlag, 1992, 43-50.
27. Miller AB, Hoogstraten B, Staquet M, Winkler A. Reporting results of cancer treatment. Cancer 1981;47:207-14.
28. Donnadieu N, Paesmans M, Sculier JP. Chemotherapy of non small cell lung cancer according to disease extent; a meta-analysis of the literature. Lung Cancer 1991;7:243-52.
29. Martínez-Monge R, Herreros J, Aristu JJ, Aramendia JM, Azinovic I. Combined treatment in superior sulcus tumors. Am J Clin Oncol 1994;17:317-22.