Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

European Journal of Medicinal Chemistry

Volumn 32, Issue 5, 1997, Pages 453-456

  Masereel, B ^a   Ouedraogo, R ^b   Dogne J M ^a   Antoine, M H ^b   De Tullio, P ^a   Pirotte, B ^a   Pochet, L ^a   Delarge, J ^a   Lebrun, P ^b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Diabetes; Insulin secretion; Sulfonamidonitroethylene; Sulfonylcyanoguanidine

Indexed keywords

ANTIDIABETIC AGENT; GLIBENCLAMIDE; SULFONYLUREA DERIVATIVE; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; FEMALE; INSULIN RELEASE; LIPOPHILICITY; NONHUMAN; PANCREAS ISLET CELL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0031004661     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)81682-0     Document Type: Article

References (12)

1. Thornber CW (1979) Chem Soc Rev 8, 563-580
2. Durant GJ, Emmett JC, Ganellin CR (1977) J Med Chem 20, 901-906
3. Brogden RN (1979) Drugs 24, 267-303
4. Lambert DM, Masereel B, Gallez B, Geurts M, Scriba GKE (1996) J Pharm Sci 85, 1077-1081
5. Masereel B, Dupont L, Laeckmann D et al (1995) Eur J Med Chem 30, 343-351
6. Arndt F, Martrus C (1932) Justus Liebigs Ann Chem 499, 228-287
7. Weber H, Aumüller W, Muth K et al (1969) Drug Research/Arz Forschung 19, 1326-1346
8. Hantzsch A, Wolvekamp M (1904) Justus Liebigs Ann Chem 331, 264-297
9. Gompper R, Schaefer H (1967) Chem Ber 100, 591-604
10. Geisen K (1988) Drug Research/Arz Forschung 38, 1120-1130
11. Cloux JL, Crommen J, Delarge J, Pirard ML, Thunus L (1988) J Pharm Belg 43, 141-151
12. Lebrun P, Antoine MH, Ouedraogo R et al (1996) J Pharmacol Exp Ther 277, 156-162