Thymic regression and apoptosis in the rat after treatment with the Leydig cell cytotoxin ethylene dimethanesulphonate (EDS)

Toxicology

Volumn 120, Issue 1, 1997, Pages 19-27

  Morris, I D ^a   Lendon, R G ^a   Waters, C ^a   Naylor, G ^a   Jones, N ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Apoptosis; Cell death; Ethylene dimethanesulphonate; Leydig cell; Thymocyte; Thymus

Indexed keywords

ETHYLENE GLYCOL DIMESYLATE; METHYLPREDNISOLONE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOCYTE; THYMUS;

ANIMALS; APOPTOSIS; CASTRATION; CELL COUNT; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; DNA FRAGMENTATION; ELECTROPHORESIS, AGAR GEL; FEMALE; GLUCOCORTICOIDS; INJECTIONS, INTRAPERITONEAL; LEYDIG CELLS; LYMPH NODES; MALE; MESYLATES; METHYLPREDNISOLONE; ORGAN SIZE; RATS; RATS, INBRED STRAINS; THYMUS GLAND;

ANIMALIA;

EID: 0031004624     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)03626-3     Document Type: Article

References (48)

1. Aronson, M. (1989) Reversible thymic collapse following acute stress is beneficial: a hypothesis. Thymus 14, 61-63.
2. Buggia, I., Locatelli, F., Regazzi, M.B. and Zecca, M. (1994) Busulfan. Ann. Pharmacother. 28, 1055-1062.
3. Cairns, J.S., Mainwaring, M.S., Cacchione, R.N., Walker, J.A. and McCarthy, S.A. (1993) Regulation of apoptosis in thymocytes. Thymus 21, 177-193.
4. Chow, S.C., Peters, I. and Orrenius, S. (1995) Re-evaluation of the role of de novo protein synthesis in rat thymocyte apoptosis. Exp. Cell. Res. 216, 149-159.
5. Damber, J.E., Bergh, A. and Widmark, A. (1987) Testicular blood flow and microcirculation in rats after treatment with ethane dimethyl sulfonate. Biol. Reprod. 37, 1291-1296.
6. Edwards, G., Lendon, R.G. and Morris, I.D. (1988) Accelerated recovery of Leydig cells of the immature rat after administration of the cytotoxic EDS. J. Endocrinol. 119, 475-482.
7. Edwards, K., Craig, A.W., Jackson, H. and Jones, A.R. (1969) Studies with alkylating esters-1: the fate of ethylene dimethanesulphonate. Biochem. Pharmacol. 18, 1693-1700.
8. Ehling, U.H. and Neuhauser-Klaus, A. (1995) Induction of specific-locus and dominant lethal mutations in male mice by n-propyl and isopropyl methanesulfonate. Mutat. Res. 328, 73-82.
9. Evans, D.L., Tilby, M. and Dive, C. (1994) Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation. Cancer Res. 54, 1594-1603.
10. Fesus, L., Szondy, Z. and Uray, I. (1995) Probing the molecular program of apoptosis by cancer preventative agents. J. Cell. Biochem. Suppl. 22, 151-161.
11. Frazier, D.E., Silverstone, A.E. and Gasiewicz, T.A. (1994) 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor. Biochem. Pharmacol. 47, 2039-2048.
12. Harvey, P.W., Fernandes, C., Rush, K.C., Major, I.R. and Cockburn, A. (1992) Corticosterone does not cause testicular toxicopathology in the rat: relevance to methylxanthines. ACTH and stress. Hum. Exp. Toxicol. 11, 505-509.
13. Hedger, M.P. and Hettiarachchi, S. (1994) Measurement of immunoglobulin G levels in adult rat testicular interstitial fluid and serum. J. Androl. 15, 583-590.
14. Jackson, C.M. and Jackson, H. (1984) Comparative protective actions of gonadotrophins and testosterone against the ant-spermatogenic action of ethylene dimethanesulphonate. J. Reprod. Fertil. 71, 393-401.
15. Jackson, H., Jackson, C.M. and Jones, P. (1973) Hormonal antagonism to the antispermatogenic effect of ethylene-dimethanesulphonate. J. Reprod. Fertil. 34, 133-135.
16. Jondal, M., Xue, Y., McConkey, D.J. and Okret, S. (1995) Thymocyte apoptosis by glucocorticoids and cAP. Curr. Top. Microbiol. Immunol. 200, 67-79.
17. Kelce, W.R. (1994) Buthionine sulfoximine protects the viability of adult rat Leydig cells exposed to ethane dimethanesulfonate. Toxicol. Appl. Pharmacol. 125, 237-246.
18. Kelce, W.R. and Zirkin, B.R. (1993) Mechanism by which ethane dimethanesulfonate kills adult rat Leydig cells: involvement of intracellular glutathione. Toxicol. Appl. Pharmacol. 120, 80-88.
19. Kerr, J.B., Bartlett, J.M. and Donachie, K. (1986) Acute response of testicular interstitial tissue in rats to the cytotoxic drug ethane dimethanesulphonate. An ultrastructural and hormonal assay study. Cell. Tissue Res. 243, 405-414.
20. Kerr, J.B., Bartlett, J.M., Donachie, K. and Sharpe, R.M. (1987) Origin of regenerating Leydig cells in the testis of the adult rat. An ultrastructural, morphometric and hormonal assay study. Cell. Tissue Res. 249, 367-377.
21. Kerr, J.B., Maddocks, S. and Sharpe, R.M. (1992) Testosterone and FSH have independent, synergistic and stage-dependent effects upon spermatogenesis in the rat testis. Cell. Tissue Res. 268, 179-189.
22. Kerr, J.B., Savage, G.N., Millar, M. and Sharpe, R.M. (1993) Response of the seminiferous epithelium of the rat testis to withdrawal of androgen: evidence for direct effect upon intercellular spaces associated with Sertoli cell junctional complexes. Cell. Tissue Res. 274, 153-161.
23. Klinefelter, G.R., Roberts, N.L. and Suarez, J.D. (1992) Direct effects of ethane dimethanesulphonate on epididymal function in adult rats. An in vitro demonstration. J. Androl. 13, 409-421.
24. Klinefelter, G.R., Laskey, J.W., Perreault, S.D., Ferrell, J., Jeffay, S., Suarez, J. and Roberts, N. (1994) The ethane dimethanesulfonate-induced decrease in the fertilizing ability of cauda epididymal sperm is independent of the testis. J. Androl. 15, 318-327.
25. Kumar, N., Shan, L.X., Hardy, M.P., Bardin, C.W. and Sundaram, K. (1995) Mechanism of androgen-induced thymolysis in rats. Endocrinology 136, 4887-4893.
26. Leeming, G., Lendon, R., McLean, J.M. and Morris, I.D. (1991) Changes in the rat lymphoid tissues after Leydig cell destruction by EDS. Exp. Pathol. 41, 115-120.
27. Liu, X., Temple-Smith, P. and Risbridger, G.P. (1993) Acute effects of ethane dimethanesulfonate (EDS) on the structure of the cauda epididymis in the rat: selective destruction of clear cells in the proximal region. Reprod. Fertil. Dev. 5, 295-306.
28. Minucci, S., Di Matteo, L., Fasano, S., Chieffi Baccari, G. and Pierantoni, R. (1994) Regeneration of the testicular interstitial compartment after ethane dimethane sulfonate treatment in the hypophysectomized frog Rana esculenta: independence of pituitary control. Gen. Comp. Endocrinol. 95, 84-91.
29. Morris, A.J., Taylor, M.F. and Morris, I.D. (1997) Leydig cell apoptosis in response to ethylene dimethanesulphonate both in vivo and in vitro. J. Androl. (in press).
30. Morris, I.D. (1996) The toxicology of the Leydig cell. In: Payne, A.H., Hardy, M.P. and Russell, L.D. (Eds.) The Leydig Cell, Cache River Press, Vienna, USA, Ch. 29, pp. 573-572.
31. Morris, I.D. (1985) Leydig cell resistance to the cytotoxic effect of ethylene dimethanesulphonate in the adult rat testis. J. Endocrinol. 105, 311-316.
32. Morris, I.D. and Jackson, C.M. (1978) Gonadotrophin response after castration and selective destruction of the testicular interstitium in the normal and aspermatogenic rat. Acta. Endocrinol. (Copenh) 88, 38-47.
33. Morris, I.D. and McCluckie, J.A. (1979) Temporal changes in serum androgen after temporary impairment of Leydig cell function by ethane 1,2 dimethanesulphonate. J. Steroid. Biochem. 10, 467-469.
34. Morris, I.D., Phillips, D.M. and Bardin, C.W. (1986) Ethylene dimethanesulfonate destroys Leydig cells in the rat testis. Endocrinology 118 (2, Feb), 709-719.
35. Rommerts, F.F.G., Teerds, K.J. and Hoogerbrugge, J.W. (1988) In vitro effects of ethylene dimethanesulphonate (EDS) on Leydig cells: inhibition of steroid production and cytotoxic effects are dependent on species and age of rats. Mol. Cell. Endocrinol. 55, 87-94.
36. Sakaguchi, Y., Stephens, L.C., Makino, M., Kaneko, T., Strebel, F.R., Danhauser, L.L., Jenkins, G.N. and Bull, J.M. (1994) Apoptosis in normal tissue induced by 5-fluorouracil: comparison between bolus injection and prolonged infusion. Anticancer Res. 14, 1489-1492.
37. Schwartzman, R.A. and Cidlowski, J.A. (1993) Mechanism of tissue specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids. Endocrinology 133, 591-599.
38. Seeley, M.R. and Faustman, E.M. (1995) Toxicity of four alkylating agents on in vitro embryo differentiation and development. Fundam. Appl. Toxicol. 26, 136-142.
39. Sharpe, R.M., Maddocks, S. and Kerr, J.B. (1990) Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement. Am. J. Anat. 188, 3-20.
40. Shealy, Y.F. and Krauth, C.A. (1993) Synthesis and antineo-plastic evaluation of alpha-substituted alkanesulfonates: analogues of clomesone. J. Pharm. Sci. 82, 1200-1204.
41. Smart, J.L., Massey, R.F., Lendon, R. and Morris, I.D. (1990) Growth and development of male and female rats treated with the Leydig cell cytoxin ethane 1,2 dimethanesulphonate during the suckling period. Food Chem. Toxicol. 28, 121-128.
42. Smith, C.A., Williams, G.T., Kingston, R., Jenkinson, E.J. and Owen, J.T.T. (1989) antibodies to CD3/T receptor complex induce death by apoptosis in immature thymic cells. Nature 337, 181-184.
43. Troiano, L., Fustini, M.F., Lovato, E., Frasoldati, A., Malorni, W., Capri, M., Grassilli, E., Marrama, P. and Franceschi, C. (1994) Apoptosis and spermatogenesis: evidence from an in vivo model of testosterone withdrawal in the adult rat. Biochem. Biophys. Res. Commun. 202, 1315-1321.
44. Veldhuizen-Tsoerkan, M.B., Ivell, R. and Teerds, K.J. (1994) hCG-induced changes in LH/CG receptor mRNA transcript levels in the testis of adult hypophysectomized, ethane dimethyl sulphonate-treated rats. Mol. Cell. Endocrinol. 105, 37-44.
45. Wang, J., Wreford, N.G., Lan, H.Y., Atkins, R. and Hedger, M.P. (1994) Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants. Biol. Reprod. 51, 551-561.
46. Wyllie, A.H. (1980) Glucocorticoid-induced apoptosis is associated with endonuclease activation. Nature 284, 555-556.
47. Wyllie, A.H. (1993) Apoptosis. Br. J. Cancer 67, 205-208.
48. Zimmerman, J.L., Todd, G.C. and Tamura, R.N. (1991) Target organ toxicity and leukopenia in Fischer 344 rats given intravenous doses of vinblastine and desacetyl vinblastine. Fundam. Appl. Toxicol. 17, 482-493.