Stimulation of dog RVLM and A5 area changes sympathetic outflow to vascular beds without effect on the heart

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 272, Issue 3 41-3, 1997, Pages

  Dickerson, Linda W ^a   Panico, William H ^a   Kuhn, Frederick E ^a   Willis, Ashley C ^a   Fitzgerald, James F ^a   Meyer, Erin L ^a   Norman, Wesley P ^a   Gillis, Richard A ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

blood pressure; cardiac contractile force; catecholamine immunocytochemistry; coronary vascular bed; femoral vascular bed; L glutamate microinjection; mesenteric vascular bed; renal vascular bed

Indexed keywords

CATECHOLAMINE; GLUTAMIC ACID;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR AUTOREGULATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; FEMORAL ARTERY; HEART MUSCLE CONTRACTILE FORCE; IMMUNOCYTOCHEMISTRY; LEFT CORONARY ARTERY; MEDULLA OBLONGATA; MESENTERIC ARTERY; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RENAL ARTERY;

EID: 0031004321     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.272.3.r821     Document Type: Article

References (42)

1. Armour, J. A., and W. C. Randall. Canine left ventricular intramyocardial pressures. Am. J. Physiol. 220: 1833-1839, 1971.
2. Barnes, K. L., C. L. Chernicky, C. H. Block, and C. M. Ferrario. Distribution of catecholaminergic neuronal systems in the canine medulla oblongata and pons. J. Comp. Neurol. 274: 127-141, 1988.
3. Blessing, W. W., and Y.-W. Li. Inhibitory vasomotor neurons in the caudal ventrolateral region of the medulla oblongata. Prog. Brain Res. 81: 83-97, 1989.
4. Bonham, A. C., and I. Jeske. Cardiorespiratory effects of DL-homocysteic acid in caudal ventrolateral medulla. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H688-H696, 1989.
5. Carrive, P., R. Bandler, and R. A. L. Dampney. Viscerotopic control of regional vascular beds by discrete groups of neurons within the midbrain periaqueductal gray. Brain Res. 493: 385-390, 1989.
6. Chalmers, J., and P. Pilowsky. Brainstem and bulbospinal neurotransmitter systems in the control of blood pressure. J. Hypertens. 9: 675-694, 1991.
7. Charlton, C. G., and C. J. Heike. Substance P-containing medullary projections to the intermediolateral cell column: identification with retrogradely transported rhodamine-labeled latex microspheres and immunohistochemistry. Brain Res. 418: 245-254, 1987.
8. Connelly, J. D., L. W. McCallister, and M. P. Kaufman. Stimulation of the caudal ventrolateral medulla decreases total lung resistance in dogs. J. Appl. Physiol. 63: 912-917, 1987.
9. Dampney, R. The subretrofacial nucleus: its pivotal role in cardiovascular regulation. News Physiol. Sci. 5: 63-67, 1990.
10. Dampney, R. A. L. Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 74: 323-364, 1994.
11. Dampney, R. A. L., A. K. Goodchild, and E. Tan. Vasopressor neurons in the rostral ventrolateral medulla of the rabbit. J. Auton. Nerv. Syst. 14: 239-254, 1985.
12. Dampney, R. A. L., and R. M. McAllen. Differential control of sympathetic fibres supplying hindlimb skin and muscle by subretrofacial neurones in the cat. J. Physiol. Lond. 395: 41-56, 1988.
13. Dean, C., J. L. Seagard, F. A. Hopp, and J. P. Kampine. Differential control of sympathetic activity to kidney and skeletal muscle by ventral medullary neurons. J. Auton. Nerv. Syst. 37: 1-10, 1988.
14. Dickerson, L. W., F. E. Kuhn, W. H. Panico, W. P. Norman, and R. A. Gillis. Activation of the rostral ventrolateral medulla (RVLM) in dogs elicits an increase in arterial pressure (BP) without an increase in heart rate (HR). Soc. Neurosci. Abstr. 19: 951, 1993.
15. Dormer, K. J., M. Anwar, S. R. Ashlock, and D. A. Ruggiero. Organization of presumptive catecholamine-synthesizing neurons in the canine medulla oblongata. Brain Res. 601: 41-64, 1993.
16. Dormer, K. J., and T. G. Bedford. Cardiovascular control by the rostral ventrolateral medulla in the conscious dog. Prog. Brain Res. 81: 265-277, 1989.
17. Gatti, P. J., P. J. Homby, A. K. Mandal, W. P. Norman, A. M. T. DaSilva, and R. A. Gillis. Cardiovascular neurons in cat caudal ventrolateral medulla: location and characterization of GABAergic input. Brain Res. 693: 80-87, 1995.
18. Gillis, R. A., W. Flacke, J. M. Garfield, and M. H. Alper. Actions of anticholinesterase agents on ganglionic transmission in the dog. J. Pharmacol. Exp. Therap. 163: 277-286, 1968.
19. Gutterman, D. D., A. C. Bonham, J. M. Arthur, G. F. Gebhart, M. L. Marcus, and M. J. Brody. Central neural regulation of coronary blood flow. In: Brain Peptides and Catecholamines in Cardiovascular Regulation, edited by J. P. Buckley and C. M. Ferrarrio. New York: Raven, 1987, p. 125-137.
20. Helke, J. J., K. B. Thor, and C. A. Sasek. Chemical neuro-anatomy of the parapyramidal region of the ventral medulla in the rat. Prog. Brain Res. 81: 17-28, 1989.
21. Huangfu, D., L.-J. Hwang, T. A. Riley, P. G. Guyenet. Splanchnic nerve response to A5 area stimulation in rats. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R437-R446, 1992.
22. Janes, R. D., D. E. Johnstone, J. D. Brandys, and J. A. Armour. Functional and anatomical variability of canine cardiac sympathetic efferent pathways: implications for regional denervation of the left ventricle. Can. J. Physiol. Pharmacol. 64: 958-969, 1986.
23. Jansen, A. S. P., X. V. Nguyen, V. Karpitskiy, T. C. Mettenleiter, and A. D. Loewy. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science Wash. DC 270: 644-646, 1995.
24. Lovick, T. A. Differential control of cardiac and vasomotor activity by neurones in nucleus paragigantocellularis lateralis in the cat. J. Physiol. Lond. 389: 23-35, 1987.
25. Mandal, A. K., K. J. Kellar, W. P. Norman, and R. A. Gillis. Stimulation of serotonin 2 receptors in the ventrolateral medulla of the cat results in nonuniform increases in sympathetic outflow. Circ. Res. 67: 1267-1280, 1990.
26. Marson, L., and A. D. Loewy. Topographic organization of substance P and monoamine cells in the ventral medulla of the cat. J. Auton. Nerv. Syst. 14: 271-285, 1985.
27. Massari, V. J., T. A. Johnson, I. J. Llewellyn-Smith, and P. J. Gatti. Substance P nerve terminals synapse on negative chronotropic vagal motoneurons. Brain Res. 660: 275-287, 1994.
28. McAllen, R. M. Action and specificity of ventral medullary vasopressor neurones in the cat. Neuroscience 18: 51-59, 1986.
29. McAllen, R. M. Identification and properties of subretrofacial bulbospinal neurones: a descending cardiovascular pathway in the cat. J. Auton. Nerv. Syst. 17: 151-164, 1986.
30. McAllen, R. M., and R. A. L. Dampney. The selectivity of descending vasomotor control by subretrofacial neurons. Prog. Brain Res. 81: 233-242, 1989.
31. McAllen, R. M., and C. N. May. Differential drives from rostral ventrolateral medullary neurons to three identified sympathetic outflows. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R935-R944, 1994.
32. Meyer, E. L., L. W. Dickerson, W. P. Norman, and R. A. Gillis. Immunohistochemical studies of sites in the ventrolateral medulla that exert control over cardiovascular function. Soc. Neurosci. Abstr. 20: 1061, 1994.
33. Minson, J. B., J. P. Chalmers, A. C. Caon, and B. Renaud. Separate areas of rat medulla oblongata with populations of serotonin- and adrenaline-containing neurons alter blood pressure after L-glutamate stimulation. J. Auton. Nerv. Syst. 19: 39-50, 1987.
34. Morrison, S. F., J. Callaway, T. A. Milner, and D. J. Reis. Rostral ventrolateral medulla: a source of the glutamatergic innervation of the sympathetic intermediolateral nucleus. Brain Res. 562: 126-135, 1991.
35. National Institutes of Health. (NIH) Guide for the Care and Use of Laboratory Animals [DHHS Publication No. (NIH) 85-23, Revised 1985, Office of Science and Health Reports, Bethesda, MD 20892].
36. Nicholson, C. Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res. 333: 325-329, 1985.
37. Ross, C. A., D. A. Ruggiero, D. H. Park, T. H. Joh, A. F. Sved, J. Fernandez-Pardal, J. M. Saavedra, and D. J. Reis. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin. J. Neurosci. 4: 474-494, 1984.
38. Ross, C. A., D. A. Ruggiero, and D. J. Reis. Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla. J. Comp. Neurol. 242: 511-534, 1985.
39. Ruggiero, D. A., P. J. Gatti, R. A. Gillis, W. P. Norman, M. Anwar, and D. J. Reis. Adrenaline-synthesizing neurons in the medulla of the cat. J. Comp. Neurol. 252: 532-542, 1986.
40. Stith, R. D., and K. J. Dormer. Pressor and endocrine responses to lesions of canine rostral ventrolateral medulla. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H2520-H2526, 1994.
41. Strack, A. M., W. B. Sawyer, K. B. Platt, and A. D. Loewy. CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Res. 491: 274-296, 1989.
42. Willette, R. N., S. Punnen-Grandy, A. J. Krieger, and H. N. Sapru. Differential regulation of regional vascular resistance by the rostral and caudal ventrolateral medulla in the rat. J. Auton. Nerv. Syst. 18: 143-151, 1987.