The addition of continuous intravenous infusion of ketorolac to a patient-controlled analgetic morphine regime reduced postoperative myocardial ischemia in patients undergoing elective total hip or knee arthroplasty

Anesthesia and Analgesia

Volumn 84, Issue 4, 1997, Pages 715-722

  Beattie, W Scott ^a   Warriner, C Brian ^b   Etches, Richard ^c   Badner, Neal H ^d   Parsons, Dave ^e   Buckley, Norm ^a   Chan, Vincent ^f   Girard, Michel ^g  

^a MCMASTER UNIVERSITY   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d LONDON HEALTH SCIENCES CENTRE   (Canada)

^e VANCOUVER GENERAL HOSPITAL   (Canada)

^f TORONTO WESTERN HOSPITAL   (Canada)

^g UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KETOROLAC; MORPHINE SULFATE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART INFARCTION; HUMAN; INTRAVENOUS ANESTHESIA; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; PATIENT CONTROLLED ANALGESIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT DEPRESSION; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT;

AGED; ANALGESIA, PATIENT-CONTROLLED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; ELECTROCARDIOGRAPHY; HIP PROSTHESIS; HUMANS; INFUSIONS, INTRAVENOUS; KETOROLAC; KNEE PROSTHESIS; MIDDLE AGED; MYOCARDIAL ISCHEMIA; POSTOPERATIVE COMPLICATIONS; TOLMETIN;

EID: 0031003794     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199704000-00003     Document Type: Article

References (35)

1. Forrest JB, Cahalan MK, Rehder K, et al. Multicenter study of general anesthesia II. Results. Anesthesiology 1990;72:262-8.
2. Cohen MM, Duncan PG, Pope WDB, Wolkenstein C. A survey of 112,000 anaesthetics at one teaching hospital (1975-83). Can Anaesth Soc J 1986;33:22-31.
3. Tiret L, Desmonts JM, Hatton F, Vourc'h G. Complications associated with anaesthesia - a prospective survey in France. Can Anaesth Soc J 1986;33:336-44.
4. Forrest JB, Rehder K, Cahalan MK, Goldsmith CH. Multicenter study of general anaesthesia III. Predictors of severe perioperative adverse outcomes. Anesthesiology 1992;76:3-15.
5. Mangano DT, Browner WS, Hollenberg M, et al. Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. N Engl J Med 1990;323(26):1781-8.
6. Raby KE, Goldman L, Creager MA, et al. Correlation between preoperative ischemia and major cardiac events after peripheral vascular surgery. N Engl J Med 1989;321:1296-300.
7. Pasternac PF, Grossi EA, Baumann G, et al. Silent myocardial ischaemia monitoring predicts late as well as perioperative cardiac events in patients undergoing vascular surgery. J Vasc Surg 1992;16:171-90.
8. Beattie WS, Buckley DN, Forrest JB. Epidural morphine reduces the risk of postoperative myocardial ischaemia in patients with cardiac risk factors. Can J Anaesth 1993;40:532-41.
9. Tuman KJ, McCarthy RF, March RJ. Effects of epidural anesthesia and analgesia on coagulation and outcome after major vascular surgery. Anesth Analg 1991;73:696-704.
10. Yeager MP, Glass D, Neff RK. Epidural anesthesia and analgesia in high risk surgical patients. Anesthesiology 1987;66:729-36.
11. Christopherson R, Beattie CS, Mark SM. Perioperative morbidity in patients randomized to epidural or general anaesthesia for lower extremity vascular surgery. Anaesthesia 1993;79:422-34.
12. Mangano DT, Siliciano D, Hollenberg M, et al. Postoperative myocardial ischaemia therapeutic trials using intensive analgesia following surgery. Anesthesiology 1992;76:343-53.
13. The Steering Committee of the Physicians Health Survey. Preliminary report: findings from the aspirin component of the ongoing Physicians Health Study. N Engl J Med 1988;318:262-4.
14. Lewis HD, Davis JW, Archibald DG. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. N Engl J Med 1983;309:396-403.
15. Conrad KA, Fagan TC, Mackie MJ, Mayshar PV. Effect of ketorolac tromethamine on hemostasis in volunteers. Clin Pharmacol Ther 1988;43:542-6.
16. Kenny G, McArdle C, Aitken H. Parenteral ketoroloac: opiate-sparing effect and lack of cardiorespiratory depression in perioperative patients. Pharmacotherapy 1990;10:127S-31.
17. Forrest JB, Buckley DN, Beattie WS. Intramuscular ketorolac and PCA morphine use after major abdominal surgery. Perspect Pain Manag 1993;14:10-4.
18. Etches RC, Warriner CB, Badner N, et al. Continuous intravenous administration of ketorolac reduces pain and morphine consumption following total hip or knee arthroplasty. Anesth Analg 1995;81:1175-80.
19. Deedwana PC, Nelson JR. Pathophysiology of silent myocardial ischemia during daily life: hemodynamic evaluation by simultaneous electrocardiographic and blood pressure monitoring. Circulation 1990;82:1296-304.
20. Breslow MJ, Jordan DA, Christopherson R, et al. Epidural morphine decreases postoperative hypertension by attenuating sympathetic nervous system hyperactivity. JAMA 1989;261:3577-81.
21. Blomberg S, Emanuelsson H, Kvist H, et al. Effect of thoracic epidural anaesthesia on coronary arteries and arterioles in patients with coronary artery disease. Anesthesiology 1990;73:840-7.
22. Knight AA, Hollenberg M, London MJ, et al. Perioperative myocardial ischemia: importance of the preoperative ischemic pattern. Anesthesiology 1988;68:681-8.
23. Chung F, Houston PL, Cheng DCH, et al. Calcium channel blockade does not offer adequate protection from perioperative myocardial ischemia. Anesthesiology 1988;69:343-7.
24. Slogoff S, Keats A. Does chronic treatment with calcium channel entry blocking drugs reduce perioperative cardiac ischemia? Anesthesiology 1988;68:676-80.
25. Waters D. Proischemic complications of dihydropyridine calcium channel blockers. Circulation 1991;84:2589-600.
26. Gavaghan TP, Gebski V, Baron DW. Immediate postoperative aspirin improves vein graft patency early and late after coronary artery bypass graft surgery. Circulation 1991;83:1526-33.
27. Sanz G, Pajaron A, Alegeria E, et al. Prevention of early aortocoronary bypass occlusion by low-dose aspirin and dipyridamole. Circulation 1990;82:765-73.
28. Goldman S, Copeland J, Moritz T, et al. Saphenous vein graft patency 1 year after coronary artery bypass surgery and effects of antiplatelet therapy. Circulation 1989;80:1190-7.
29. Charlson ME, MacKenzie CR, Ales K, et al. Surveillance for postoperative myocardial infarction after noncardiac operations. Surg Gynecol Obstet 1988;167:407-14.
30. Glazier J, Piessens J. Mechanisms of painless myocardial ischaemia. J R Coll Physicians (Lond) 1991;25:102-3.
31. Hikita H, Kurita A, Takase B, et al. Usefulness of plasma betaendorphin pain threshold and autonomic function in assessing silent myocardial ischemia in patients with and without diabetes mellitus. Am J Cardiol 1993;72:140-3.
32. Kurita A, Takase B, Uehata A, et al. Difference in plasma β-endorphin and bradykinin levels between patients with painless or with painful myocardial ischemia. Am Heart J 1992;123:304-9.
33. Yang H. Intraoperative automated ST segment analysis: a reliable "black box"? Can J Anaesth 1996;43:1041-51.
34. Diamond G, Forrester JS. Analysis of probability as an aid in clinical diagnosis of coronary artery disease. N Engl J Med 1979;300:1350-8.
35. Garnett RL, MacIntrye A, Lindsay P. Perioperative ischemia in aortic surgery: combined epidural/general anesthesia and epidural analgesia vs general anesthesia and IV analgesia. Can J Anaesth 1996;43:769-78.