Effect of C-peptide on insulin and glucagon release by isolated perfused rat pancreas

Diabetes and Metabolism

Volumn 23, Issue 2, 1997, Pages 149-154

  Leclercq Meyer, V ^a   Malaisse, W J ^a   Johansson, B L ^b   Wahren, J ^b  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

C peptide; Glucagon; Insulin; Perfused pancreas

Indexed keywords

ARGININE; C PEPTIDE; GLUCAGON; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ARTICLE; FEMALE; GLUCAGON RELEASE; INSULIN RELEASE; NONHUMAN; PANCREAS; RAT;

ANIMALS; C-PEPTIDE; FEMALE; GLUCAGON; GLUCOSE; INSULIN; INSULIN ANTAGONISTS; ISLETS OF LANGERHANS; KINETICS; PERFUSION; RATS; RATS, WISTAR;

EID: 0031003565     PISSN: 03381684     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Steiner DF, Oyer PE. The biosynthesis of insulin and a probable precursor of insulin by a human islel cell adenoma. Proc Natl Acad Sci USA, 1967, 57, 473-480.
2. Steiner D. On the role of the proinsulin C-peptide. Diabetes, 1978, 27, 145-148.
3. Johansson B-L, Sjöberg S, Wahren J. The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients. Diabetologia, 1992, 35, 121-128.
4. Johansson B-L, Kernell A, Sjöberg S, Wahren J. Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. J clin Endocrinol Metab, 1993, 77, 976-981.
5. Johansson B-L, Linde B, Wahren J. Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of Type 1 (insulin-dependent) diabetic patients. Diabetologia, 1992, 35, 1151-1158.
6. Johansson B-L, Borg K, Fernqvist-Forbes E, Odergren T, Remahl S, Wahren J. C-peptide improves autonomic nerve function in IDDM patients. Diabetologia, 1996, 39, 687-695.
7. +-ATPasc activity in synergism with neuropeptide Y. Diabetologia, 1996, 39, 199-205.
8. Wojcikowski C, Blackman J, Ostrega D et al. Lack of effect of high-dose biosynthetic human C-peptide on pancreatic hormone release in normal subjects. Metabolism, 1990, 39, 827-832.
9. Toyota T, Abe K, Kudo M, Kimura K. Goto Y. Inhibitory effects of synthetic rat C-peptide 1 on insulin secretion in the isolated perfused rat pancreas. Tohoku J exp Med, 1975, 117, 79-83.
10. Wojcikowski C, Füssgänger RD, Pfeiffer EF. Inhibition of insulin and glucagon secretion of the isolated perfused rat pancreas by synthetic human and rat C-peptide. In : Beyer J, Krause U, Nacgelc W, eds. "Proceedings First International Symposium on C-peptide". Mainz : Schnetzor-Verlag Konstanz, 1977, 75-94.
11. Leclercq-Meyer V, Marchand J, Leclercq R, Malaisse WJ. Glucagon and insulin release by the in vitro perfused rat pancreases. Diab Métab, 1976, 2, 57-65.
12. Malaisse WJ, Leclercq-Meyer V, Malaisse-Lagae F. Methods for the measurement of insulin secretion in the rat. In : Hutton JC, Siddle K, eds. "Peptide hormone secretion : a practical approach". Oxford : Oxford University Press, 1990, 211-231.
13. Malaisse WJ, Malaisse-Lagae F, Wright PH. Effect of fasting upon insulin secretion in the rat. Am J Physiol, 1967, 213, 843-848.
14. Leclercq-Meyer V, Marchand J, Woussen-Colle M-C, Giroix M-H, Malaisse WJ. Multiple effects of leucine on glucagon, insulin and somatostatin secretion from the perfused rat pancreas. Endocrinology, 1985, 116, 1168-1174.
15. Harris V, Faloona GR, Unger RH., Glucagon. In : Jaffe B., Berhman H., eds. "Methods of hormone radioimmunoassay". 2nd ed. New York : Academic Press, 1978, 643-656.
16. Devis G, Somers G, Van Obberghen E, Malaisse WJ. Calcium antagonists and islet function. I. Inhibition of insulin release by verapamil. Diabetes, 1975, 24, 547-551.
17. Leclercq-Meyer V, Rebolledo O, Marchand J, Malaisse WJ. Glucagon release : paradoxical stimulation by glucose during calcium deprivation. Science, 1975, 189, 897-899.
18. Leclercq-Meyer V, Marchand J, Malaisse WJ. The role of calcium in glucagon release. Studies with verapamil. Diabetes, 1978, 27, 996-1004.
19. Cohen P, Barzilai N, Karnieli E. Suppression of insulin secretion by C-peptide infusions in humans, Isr J Med Sc., 1995, 31, 284-288.
20. Flatt PR, Swanston-Flatt SK, Hampton SM, Bailey CJ, Marks V. Specific binding of the C-peptide of proinsulin to cultured B-cells from a transplantable rat islet cell tumor. Biosci Rep, 1986, 6, 193-199.
21. Milner RDG, Hales CN. The sodium pump and insulin secretion. Biochim Biophys Acta, 1967, 135, 375-377.
22. Triner L, Killian P, Nahas GG. Ouabain hypoglycemia: insulin mediation. Science, 1968, 126, 560-561.
23. Malaisse WJ, Malaisse-Lagae F, Brisson G. The stimulus-secretion coupling of glucose-induced insulin release. II. Interaction of alkali and alkaline earth cations. Horm Metab Res, 1991, 3, 65-70.
24. +-ATPase activity: a negative feedback mechanism on insulin secretion ? [Abstract]. Diabetologia, 1996, 39 (suppl. 1), A71.
25. + fluxes in isolated islets. Pflügers Arch, 1976, 375, 197-206.