N-3 fatty acids and chylomicron metabolism in the rat

Journal of Lipid Research

Volumn 38, Issue 3, 1997, Pages 503-515

  Harris, William S ^a,b   Hustvedt, Bo E ^a,c   Hagen, Egil ^a,c   Green, Michael H ^a,d   Lu, Guoping ^a,e   Drevon, Christian A ^a,c  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b ST LUKE S HOSPITAL   (United States)

^c UNIVERSITY OF OSLO   (Norway)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

chylomicron; docosahexaenoic acid; eicosapentaenoic acid; fat absorption; multicompartmental modeling; SAAM; triacylglycerol rich lipoproteins; Triton WR1339

Indexed keywords

CHYLOMICRON; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LIPOPROTEIN LIPASE; OMEGA AMINO ACID; TYLOXAPOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DIGESTION; DRUG CLEARANCE; ENZYME ACTIVITY; HYPERLIPIDEMIA; INTESTINE ABSORPTION; LIPID ABSORPTION; LIPOPROTEIN METABOLISM; NONHUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT;

ANIMALS; BODY WEIGHT; CHYLOMICRONS; COMPUTER SIMULATION; DIETARY FATS; FATTY ACIDS, OMEGA-3; INTESTINE, SMALL; LYMPH; MALE; MODELS, BIOLOGICAL; PARTICLE SIZE; PHOSPHOLIPIDS; PLANT OILS; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SURFACE-ACTIVE AGENTS; TRIGLYCERIDES; VITAMIN A;

EID: 0031003061     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Harris, W. S., and W. E. Connor. 1980. The effects of salmon oil upon plasma lipids, lipoproteins and triglyceride clearance. Trans. Assoc. Am. Physicians. 43: 148-155.
2. Harris, W. S., W. E. Connor, N. Alam, and D. R. Illingworth. 1988. Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. J. Lipid Res. 29: 1451-1460.
3. Weintraub, M. S., R. Zechner, A. Brown, S. Eisenberg, and J. L. Breslow. 1988. Dietary polyunsaturated fats of the ω-6 and CD-3 series reduce postprandial lipoprotein levels. J. Clin. Invest. 82: 1884-1893.
4. Harris, W. S., and S. L. Windsor. 1991. N-3 fatty acid supplements reduce chylomicron levels in healthy volunteers. J. Appl. Nutr. 43: 5-15.
5. Harris, W. S., and F. Muzio. 1993. Fish oil reduces posprandial triglyceride concentrations without accelerating lipid emulsion removal rates. Am. J. Clin. Nutr. 58: 68-74.
6. Brown, A. J., and D. C. K. Roberts. 1991. Moderate fish oil intake improves lipemic response to a standard fat meal: a study in 25 healthy men. Arterioscler. Thromb: 11: 457-466.
7. Williams, C. M., F. Moore, L. Morgan, and J. Wright. 1992. Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects. Br. J. Nutr. 68: 655-666.
8. Desager, J. P., J. Dricot, and C. Harvengt. 1989. Hypotriglyceridemic action of omega-3 fatty acids in healthy subjects does not occur by enhanced lipoprotein lipase and hepatic lipase activities. Res. Commun. Chem. Pathol. Pharmacol. 65: 269-272.
9. Nozaki, S., A. Garg, G. L. Vega, and S. M. Grundy. 1991. Postheparin lipolytic activity and plasma lipoprotem response to ω-3 polyunsaturated fatty acids in patients with primary hypertriglyceridemia. Am. J. Clim. Nutr. 53: 638-642.
10. Haug, A., A. T. Hostmark. 1987. Lipoprotein lipases, lipoproteins and tissue lipids in rats fed fish oil or coconut oil. J. Nutr. 117: 1011-1017.
11. Daggy, B., C. Arost, and A. Bensadoun. 1987. Dietary fish oil decreases VLDL production rates. Biochim. Biophys. Acta. 920: 293-300.
12. Huff, M. W., D. E. Telford, B. W. Edmonds, C. G. McDonald, and A. J. Evans. 1993. Lipoprotein lipases, lipoprotein density gradient profile and LDL receptor activity in miniature pigs fed fish oil and corn oil. Biochim. Biophys. Acta. 1210: 113-122.
13. Harris, W. S. 1989. Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. J. Lipid Res. 30: 785-807.
14. Herzberg, G. R., G. A. Chemenko, J. A. Barrowman, K. T. Keat, and K. M. W. Keough. 1992. Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. Biochim. Biophys. Acta. 1124: 190-194.
15. Rustan, A. C., B. E. Hustvedt, and C. A. Drevon. 1993. Dietary supplementation of very long chain n-3 fatty acids decreases whole body lipid utilization in the rat. J. Lipid Res. 34: 1299-1309.
16. Otway, S., and D. S. Robinson. 1967. The use of the nonionic detergent (Triton WR1339) to determine rates of triacylglycerol entry into the circulation of the rat under different physiological conditions. J. Physiol. 190: 321-332.
17. Blomhoff, R., P. Helgerud, S. Dueland, T. Berg, J. I. Pedersen, K. R. Norum, and C. A. Drevon. 1984. Lymphatic absorption and transport of retinol and vitamin D3 from rat intestine. Biochim. Biophys. Acta. 772: 109-116.
18. Kalogeris, T., and J. A. Story. 1992. Lymph chylomicron size is modified by fat saturation in rats. J. Nutr. 122: 1634-1642.
19. Mortimer, B. C., Y. Umeda, C. L. Elsegood, and T. Redgrave. 1993. Effect of anesthesia on the removal from plasma of i.v. injected chylomicron-like lipid emulsion in rats and mice. Clin. Exp. Pharmacol. Physiol. 20: 51-59.
20. Harkness, J. and J. Wagner 1977. Biology and Medicine of Rabbits and Rodents. Lea & Febiger, Philadelphia. 271.
21. Green, M. H., and J. B. Green. 1990. The application of compartmental analysis to research in nutrition. Annu. Rev. Nutr. 10: 41-61.
22. Green, M. H., E. R. Massaro, and J. B. Green. 1984. Multicompartmental analysis of the effects of dietary fat saturation and cholesterol on absorptive lipoprotein metabolism in the rat. Am. J. Clin. Nutr. 40: 82-94.
23. Green, M. H., J. B. Green, T. Berg, K. R. Norum, and R. Blomhoff. 1993. Vitamin A metabolism in rat liver: a kinetic model. Am. J. Physiol. 264: G509-G521.
24. Berr, F., and F. Kern. 1984. Plasma clearance of chylomicrons labeled with retinyl palmitate in healthy human subjects. J. Lipid Res. 25: 805-812.
25. Blaner, W. S., J. C. Obunike, S. B. Kurlandsky, M. Al-Haideri, R. Piantedosi, R. J. Deckelbaum, and I. J. Goldberg. 1994. Lipoprotein lipase hydrolysis of retinyl ester: possible implications for retinoid uptake by cells. J. Biol. Chem. 269: 16559-16565.
26. Krasinski, S. D., J. S. Cohn, R. M. Russell, and E. J. Schaefer. 1990. Postprandial plasma vitamin A metabolism in humans: a reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants. Metabolism. 39: 357-365.
27. Karpe, F., M. Bell, J. Bjorkegren, and A. Hamsten. 1995. Quantification of postprandial triglyceride-rich lipoproteins in healthy men by retinyl ester labeling and simultaneous measurement of apolipoproteins B-48 and B-100. Arterioscler. Thromb. Vasc. Biol. 15: 199-207.
28. Berman, M., W. F. Beltz, P. C. Greif, R. Chabay, and R. C. Boston. 1983. CONSAM. Users Guide. U.S. Govt. Printing Office, Washington, DC. 1983-421-132:3279.
29. Berman, M., and M. F. Weiss. 1978. SAAM Manual. U.S. Govt. Printing Office, Washington, DC. DHEW Publication No. (NIH) 78-180.
30. Fraser, R. 1970. Size and lipid composition of chylomicrons of different Svedberg units of flotation. J. Lipid Res. 11: 60-65.
31. Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
32. Frolick, C. A., and J. A. Olson, 1984. In The Retinoids, M. B. Spom, A. B. Roberts, D. S. Goodman, editors. Academic Press, New York. 182-235.
33. Blomhoff, R., M. Rasmussen, A. Nilsson, K. R. Norum, T. Berg, W. S. Blaner, M. Kato, J. R. Mertz, D. S. Goodman, U. Eriksson, et al. 1985. Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells. J. Biol. Chem. 260: 13560-13565.
34. Mason, M. E., and G. R. Waller, 1964. Dimethoxypropane induces transesterification of fats and oils in preparation of methyl esters for gas chromatographic analysis. Anal. Chem. 36: 583-586.
35. Lewis, B., A. Chait, A. W. February, and M. Mattock. 1973. Functional overlap between "chylomicra" and "very low density lipoproteins" of human plasma during alimentary lipaemia. Atherosclerosis. 17: 455-462.
36. Berman, M. 1979. Kinetic analysis of turnover data. Prog. Biochem. Pharmacol. 15: 67-108.
37. 3H]retinyl ester by rat liver evidence for retinol transfer from parenchymal to non-parenchymal cells. Proc. Natl. Acad. Sci. USA. 79: 7326-7330.
38. Wong, S., E. A. Fisher, and J. B. Marsh. 1989. Effects of eicosapentaenoic and docosahexaenoic acids on apoprotein B mRNA and secretion of very low density lipoprotein in HepG2 cells. Arteriosclerosis. 9: 836-841.
39. Rustan, A. C., J. O. Nossen, E. N. Christiansen, and C. A. Drevon. 1988. Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase. J. Lipid Res. 29: 1417-1426.
40. Marsh, J. B., D. L. Topping, and P. J. Nestel. 1987. Comparative effects of dietary fish oil and carbohydrate on plasma lipids and hepatic activities of phosphatidate phosphohydrolase, diacylglycerol acyltransferase and neutral lipase activities in the rat. Biochim. Biophys. Acta. 922: 239-243.
41. Wang, H., X. Chen, and E. A. Fisher. 1993. N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes. J. Clin. Invest. 92: 1380-1389.
42. Harris, W. S., W. E. Connor, D. R. Illingworth, D. W. Rothrock, and D. M. Foster. 1990. Effects of fish oil on VLDL triglyceride kinetics in humans. J. Lipid Res. 31: 1549-1558.
43. Nestel, P. J., W. E. Connor, M. R. Reardon, S. L. Connor, S. Wong, and R. Boston. 1984. Suppression by diets rich in fish oil of very low density lipoprotein production in man. J. Clin. Invest. 74: 72-89.
44. Sanders, T. A. B., D. R. Sullivan, J. Reeve, and G. R. Thompson. 1985. Triglyceride-lowering effect of marine polyunsaturates in patients with hypertriglyceridemia. Arteriosclerosis. 5: 459-465.
45. Coleman, R. A., and E. B. Haynes. 1986. Monoacylglycerol acyltransferase. Evidence that the activities from rat intestine and suckling liver are tissue-specific isoenzynies. J. Biol. Chem. 261: 224-228.
46. Murthy, S., E. Albright, S. N. Mathur, and F. J. Field. 1990. Effect of eicosapentaenoic acid on triacylglycerol transport in CaCo-2 cells. Biochim. Biophys. Acta. 1045: 147-155.
47. Ranheim, T., A. Gedde-Dahl, A. C. Rustan, and C. A. Drevon. 1994. Effect of chronic incubation of CaCo-2 cells with eicosapentaenoic acid (20:5, n-3) and oleic acid (18: 1, n-9) on triacylglycerol production. Biochem. J. 393: 155-161.
48. Trotter, P. J., and J. Storch. 1993. Fatty acid esterification during differentiation of the human intestinal cell line CaCo-2. J. Biol. Chem. 268: 10017-10023.
49. Tso, P., and K. Fujimoto. 1991. The absorption and transport of lipids by the small intestine. Brain Res. Bull. 27: 477-482.
50. Herzberg, G. R., and M. Rogerson. 1989. The effect of dietary fish oil on muscle and adipose tissue lipoprotein lipase. Lipids. 24: 351-353.
51. Borensztajn, J., and T. J. Kotlar. 1990. Phospholipids as modulators of hepatic recognition of chylomicron remnants. Biochem. J. 269: 539-542.
52. Robins, S. F., J. M. Fasula, and G. M. Patton. 1988. Effect of different molecular species of phosphatidylcholine on the clearance of emulsion particle lipids. J. Lipid Res. 29: 1195-1203.
53. Brasaemie, D. L., K. Comely-Moss, and A. Bensadoun. 1993. Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E. J. Lipid Res. 34: 455-465.
54. Brown, D. F., A. S. Heslin, and J. T. Doyle. 1961. Postprandial lipemia in health and ischemic heart disease. N. Engl. J. Med. 264: 733-737.
55. Berr, F., R. Eckel, and F. Kern. 1985. Plasma decay of chylomicron remnants is not affected by heparin-stimulated plasma lipolytic activity in normal fasting man. J. Lipid Res. 26: 852-859.
56. Levy, E., C. C. Roy, R. Goldstein, H. Bar-On, and E. Ziv. 1991. Metabolic fate of chylomicrons obtained from rats maintained on diets varying in fatty acid composition. J. Am Coll. Nutr. 10: 69-78.
57. 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo. J. Biol. Chem. 21: 15804-15811.
58. Roach, P. D., A. M. Kambouris, R. P. Trimble, D. L. Topping, and P. J. Nestel. 1987. The effects of dietary fish oil on hepatic HDL and LDL receptor activities in the rat. FEBS Lett. 222: 159-162.
59. Ventura, M. A., L. A. Woollett, and D. K. Spady. 1989. Dietary fish oil stimulates hepatic low density lipoprotein transport in the rat. J. Clin. Invest. 84: 528-537.
60. Nestel, P. J. 1964. Relationship between plasma triglycerides and removal of chylomicrons. J. Clin. Invest. 43: 943-949.
61. Brunzell, J., W. R. Hazzard, D. J. Porte, and E. L. Bierman. 1973. Evidence for a common, saturable, triglyceride removal mechanism for chylomicrons and very low density lipoproteins in man. J. Clin. Invest. 52: 1578-1585.
62. Harris, W. S. 1996. n-3 fatty acids and lipoproteins: comparison of results from human and animal studies. Lipids. 31: 943-252.
63. Eckel, R. H. 1989. Lipoprotein lipase-a multifunctional enzyme relevant to common metabolic leases. N. Engl. J. Med. 320: 1060-1069.
64. Karpe, F., and M. Hultin. 1995. Endogenous triglyceride-rich lipoproteins accumulate in rat plasma when competing with a chylomicron-like triglyceride emulsion for a common lipolytic pathway. J. Lipid Res. 36: 1557-1566.
65. Hultin, M., A. Mullertz, M. A. Zundel, G. Olivecrona, T. T. Hansen, R. J. Deckelbaum, Y. A. Carpentier, and T. Olivecrona. 1994. Metabolism of emulsions containing medium- and long-chain triglycerides or interesterified triglycerides. J. Lipid Res. 35: 1850-1860.
66. Eckel, R. H. 1987. In Lipoprotein Lipase. J. Borensztajn, editor Evener Publishers, Chicago. Am 79-132.
67. Cohen, J. C. 1989. Chylomicron triglyceride clearance: a comparison of three assessment methods. Am. J. Clin. Nutr. 49: 306-313.