Chemotherapy of cerebral malaria: Current recommendations for treatment and prophylaxis

CNS Drugs

Volumn 7, Issue 5, 1997, Pages 366-380

  Wilairatana, Polrat ^a   Looareesuwan, Sornchai ^a,c   Walsh, Douglas S ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b U S ARMY   (United States)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; ARTESUNATE; CHLOROQUINE; QUINIDINE; QUININE;

BRAIN MALARIA; CHEMOPROPHYLAXIS; CLINICAL FEATURE; DRUG CHOICE; DRUG EFFICACY; INTRAMUSCULAR DRUG ADMINISTRATION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031002936     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199707050-00004     Document Type: Review

References (116)

1. Implementation of the global malaria control strategy. Report of a WHO Study Group on the Implementation of the Global Plan of Action for Malaria Control 1993-2000. World Health Organ Tech Rep Ser 1993; 839: 1-57
2. Pasvol G, Clough B, Carlsson J, et al. The pathogenesis of severe falciparum malaria. Baillieres Clin Infect Dis 1995; 2 (2): 249-70
3. Warrell DA, Molyneux ME, Beales PF. Severe and complicated malaria. Trans R Soc Trop Med Hyg 1990; 84 Suppl. 2: 1-65
4. Marsh K, Forster D, Waruiru C, et al. Indicators of life-threatening malaria in African children. N Engl J Med 1995; 332 (21): 1399-404
5. Ho M, Sexton MM. Clinical immunology of malaria. Baillieres Clin Inf Dis 1995; 2 (2): 227-47
6. Walsh DS, Looareesuwan S, Vaniganonta S, et al. Cutaneous delayed-type hypersensitivity responsiveness in patients during and after Plasmodium falciparum and Plasmodium vivax infections. Clin Immunol Immunopathol 1995; 77 (1): 89-94
7. Ockenhouse CF, Ho M, Tandon NN, et al. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Infect Dis 1991; 164 (1): 163-97
8. Ockenhouse CF, Tegoshi T, Maeno Y, et al. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J Exp Med 1992; 176 (4): 1183-9
9. Wenisch C, Looareesuwan S, Parschalk B, et al. Soluble vascular cell adhesion molecule 1 is elevated in patients with Plasmodium falciparum malaria [letter]. J Infect Dis 1994; 169 (3): 710-1
10. Kwiatkowski D, Cannon JG, Manogue KR, et al. Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clin Exp Immunol 1989; 77 (3): 361-6
11. Looareesuwan S, Wilairatana P, Krishna S, et al. Magnetic resonance imaging of the brain in patients with cerebral malaria. Clin Infect Dis 1995; 21 (2): 300-9
12. Anstey NM, Weinberg JB, Hassanali MY, et al. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 1996; 184 (2): 557-67
13. Brewster DR, Kwiatkowski D, White NJ. Neurological sequelae of cerebral malaria in children. Lancet 1990; 336 (8722): 1039-43
14. Riganti M, Pongponratn E, Tegoshi T, et al. Human cerebral malaria in Thailand: a clinico-pathological correlation. Immunol Lett 1990; 25: 199-205
15. MacPherson GG, Warrell MJ, White NJ, et al. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am J Pathol 1985; 119 (3): 385-401
16. Looareesuwan S, Warrell DA, White NJ, et al. Do patients with cerebral malaria have cerebral oedema? A computed tomography study. Lancet 1983; 1 (8322): 434-7
17. Warrell DA, Looareesuwan S, Phillips RE, et al. Function of the blood-cerebrospinal fluid barrier in human cerebral malaria: rejection of the permeability hypothesis. Am J Trop Med Hyp 1986; 35 (5): 882-9
18. Warrell DA, White NJ, Veall N, et al. Cerebral anaerobic glycolysis and reduced cerebral oxygen transport in human cerebral malaria. Lancet 1988; 11 (8610): 534-8
19. White NJ. Lumbar puncture in cerebral malaria [letter]. Lancet 1991; 338 (8767): 640-1
20. Newton CR, Kirkham FJ, Winstanley PA, et al. Intracranial pressure in African children with cerebral malaria. Lancet 1991; 337 (8741): 573-6
21. Waller D, Crawley J, Nosten F, et al. Intracranial pressure in childhood cerebral malaria. Trans R Soc Trop Med Hyg 1991; 85 (3): 362-4
22. Lewallen S, Taylor TE, Molyneux ME, et al. Ocular fundus findings in Malawian children with cerebral malaria. Ophthalmology 1993; 100 (6): 857-61
23. Grau GE, Taylor TE, Molyneux ME, et al. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 1989; 320 (24): 1586-91
24. Kwiatkowski D. Cytokines and anti-disease immunity to malaria. Res Immunol 1991; 142: 707-12
25. Clark IA, Rockett KA, Cowden WB. Possible central role of nitric oxide in conditions clinically similar to cerebral malaria. Lancet 1992; 340 (8824): 894-6
26. Molyneux ME. The clinical manifestations and diagnosis of malaria. Baillieres Clin Infect Dis 1995; 2 (2): 271-92
27. Waller D, Krishna S, Crawley J, et al. Clinical features and outcome of severe malaria in Gambian children. Clin Infect Dis 1995; 21 (3): 577-87
28. Molyneux ME, Taylor TE, Wirima JJ, et al. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 1989; 71 (265): 441-59
29. Warrell DA. Cerebral malaria. Schweiz Med Wochenschr 1992; 122 (23): 879-86
30. Looareesuwan S. Overview: pathophysiology and management of cerebral malaria. Southeast Asian J Trop Med Public Health 1992; 23 Suppl. 4: 155-65
31. White NJ, Looareesuwan S. Cerebral malaria. In: Kennedy PGE, Johnson RT, editors. Infections of the nervous system. London: Butterworth's, 1987: 118-43
32. Looareesuwan S, Warrell DA, White NJ, et al. Retinal hemorrhage, a common sign of prognostic significance in cerebral malaria. Am J Trop Med Hyg 1983; 32 (5): 911-5
33. van Hensbroek MB, Onyiorah E, Jaffar S, et al. A trial of artemether or quinine in children with cerebral malaria. N Engl J Med 1996; 335 (2): 69-75
34. White NJ, Ho M. The pathophysiology of malaria. Adv Parasitol 1992; 31: 83-173
35. Trevett A, Lalloo D. A new look at an old drug: artemesinin and qinghaosu. P N G Med J 1992; 35 (4): 264-9
36. Field JW. The morphology of malarial parasites in thick blood films. IV. The identification of species and phase. Trans R Soc Trop Med Hyg 1941; 34: 405-14
37. Field JW, Niven JC. A note on prognosis in relation to parasite counts in acute subterian malaria. Trans R Soc Trop Med Hyg 1937; 30: 569-74
38. Nguyen PH, Day N, Pram TD, et al. Intraleucocytic malaria pigment and prognosis in severe malaria. Trans R Soc Trop Med Hyg 1995; 89 (2): 200-4
39. Beadle C, Long GW, Weiss WR, et al. Diagnosis of malaria by detection of Plasmodium falciparum HRP-2 antigen with a rapid dipstick antigen-capture assay. Lancet 1994; 343 (8897): 564-8
40. White NJ, Warrell DA. The management of severe malaria. In: Wernsdorfer W, McGregor SI, editors. Malaria. Principles and practice of malariology. New York: Churchill Livingstone, 1988: 865-88
41. Hien TT, Tam DT, Cuc NT, et al. Comparative effectiveness of artemisinin suppositories and oral quinine in children with acute falciparum malaria. Trans R Soc Trop Med Hyg 1991; 85 (2): 210-1
42. Pukrittayakamee S, Supanaranond W, Looareesuwan S, et al. Quinine in severe falciparum malaria: evidence of declining efficacy in Thailand. Trans R Soc Trop Med Hyg 1994; 88 (3): 324-7
43. White NJ, Miller KD, Churchill FC, et al. Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity, and new dosage recommendations. N Engl J Med 1988; 319 (23): 1493-500
44. White NJ. The treatment of malaria. N Engl J Med 1996; 335 (11): 800-6
45. White NJ, Krishna S, Waller D, et al. Open comparison of intramuscular chloroquine and quinine in children with severe chloroquine-sensitive falciparum malaria. Lancet 1989; 11 (8675): 1313-6
46. White NJ, Watt G, Bergqvist Y, et al. Parenteral chloroquine for treating falciparum malaria. J Infect Dis 1987; 155 (2): 192-201
47. Desjardins RE, Doberstyn EB, Wernsdorfer WH. The treatment and prophylaxis of malaria. In: Wernsdorfer WH, McGregor I, editors. Malaria. Principles and practice of malariology New York: Churchill Livingstone, 1988: 827-64
48. Looareesuwan S, White NJ, Chanthavanich P, et al. Cardiovascular toxicity and distribution kinetics of intravenous chloroquine. Br J Clin Pharmacol 1986; 22 (1): 31-6
49. Miller KD, Greenberg AE, Campbell CC. Treatment of severe malaria in the United States with a continuous infusion of quinidine gluconate and exchange transfusion [see comments]. N Engl J Med 1989; 321 (2): 65-70
50. Pasvol G, Newton CR, Winstanley PA, et al. Quinine treatment of severe falciparum malaria in African children: a randomized comparison of three regimens. Am J Trop Med Hyg 1991; 45 (6): 702-13
51. Waller D, Krishna S, Craddock C, et al. The pharmacokinetic properties of intramuscular quinine in Gambian children with severe falciparum malaria. Trans R Soc Trop Med Hyg 1990; 84 (4): 488-91
52. White NJ, Looareesuwan S, Warrell DA, et al. Quinine pharmacokinetics and toxicity in cerebral and uncomplicated Falciparum malaria. Am J Med 1982; 73 (4): 564-72
53. Winstanley P, Newton C, Watkins W, et al. Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: the importance of unbound quinine concentration. Trans R Soc Trop Med Hyg 1993; 87 (2): 201-6
54. Silamut K, Molunto P, Ho M, et al. Alpha 1-acid glycoprotein (orosomucoid) and plasma protein binding of quinine in falciparum malaria. Br J Clin Pharmacol 1991; 32 (3): 311-5
55. White NJ, Looareesuwan S, Warrell DA, et al. Quinine loading dose in cerebral malaria. Am J Trop Med Hyg 1983; 32 (1): 1-5
56. van Hensbroek MB, Kwiatkowski D, van den Berg B, et al. Quinine pharmacokinetics in young children with severe malaria. Am J Trop Med Hyg 1996; 54 (3): 237-42
57. White NJ. Optimal regimens of parenteral quinine [letter]. Trans R Soc Trop Med Hyg 1995; 89 (4): 462-4
58. Watt G, Loesuttivibool L, Shanks GD, et al. Quinine with tetracycline for the treatment of drug-resistant falciparum malaria in Thailand. Am J Trop Med Hyg 1992; 47 (1): 108-11
59. White NJ, Warrell DA, Chanthavanich P, et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med 1983; 309 (2): 61-6
60. Silamut K, Hough R, Eggelte T, et al. A simple method for assessing quinine pre-treatment in acute malaria. Trans R Soc Trop Med Hyg 1995; 89 (6): 665-7
61. Looareesuwan S, Phillips RE, White NJ, et al. Quinine and severe falciparum malaria in late pregnancy. Lancet 1985; 11 (8445): 4-8
62. White NJ, Looareesuwan S, Warrell DA. Quinine and quinidine: a comparison of EKG effects during the treatment of malaria. J Cardiovasc Pharmacol 1983; 5 (2): 173-5
63. Phillips RE, Warrell DA, White NJ, et al. Intravenous quinidine for the treatment of severe falciparum malaria. Clinical and pharmacokinetic studies. N Engl J Med 1985; 312 (20): 1273-8
64. Phillips RE, Looareesuwan S, White NJ, et al. Hypoglycaemia and antimalarial drugs: quinidine and release of insulin. BMJ (Clin Res Ed) 1986; 292 (6531): 1319-21
65. Karbwang J, Davis TM, Looareesuwan S, et al. A comparison of the pharmacokinetic and pharmacodynamic properties of quinine and quinidine in healthy Thai males. Br J Clin Pharmacol 1993; 35 (3): 265-71
66. Hien TT, White NJ. Qinghaosu. Lancet 1993; 341 (8845): 603-8
67. Qinghaousu Antimalarial Coordinating Group. Antimalarial studies on qinghaosu. Chin Med J 1979; 92: 811-6
68. World Health Organization. The role of artemisinin and its derivatives in the current treatment of malaria (1994-1995): report of an informal consultation; 1993 Sep 27-29: Geneva. Geneva: WHO/MAL, 1993; 94.1067: 1-49
69. Price RN, Nosten F, Luxemburger C, et al. Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. Trans R Soc Trop Med Hyg 1995; 89 (5): 523-7
70. ter Kuile F, White NJ, Holloway P, et al. Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Exp Parasitol 1993; 76 (1): 85-95
71. Udomsangpetch R, Pipitaporn B, Krishna S, et al. Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum. J Infect Dis 1996; 173 (3): 691-8
72. White NJ. Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S41-3
73. Li GQ, Guo XB, Fu LC, et al. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S5-6
74. White NJ, Waller D, Crawley J, et al. Comparison of artemether and chloroquine for severe malaria in Gambian children. Lancet 1992; 339 (8789): 317-21
75. Win K, Than M, Thwe Y. Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus oral tetracycline for treating cerebral malaria. Bull World Health Organ 1992; 70 (6): 777-82
76. Looareesuwan S, Viravan C, Vanijanonta S, et al. Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria. Lancet 1942; 339 (8797): 821-4
77. Looareesuwan S, Kyle DE, Viravan C, et al. Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine. Am J Trop Med Hyg 1992; 47 (6): 794-9
78. Looareesuwan S, Vanijanonta S, Viravan C, et al. Randomized trial of mefloquine alone and artesunate followed by mefloquine for the treatment of acute uncomplicated falciparum malaria. Ann Trop Med Parasitol 1994; 88 (2): 131-6
79. Barradell LB, Fitton A. Artesunate: a review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs 1995; 50 (4): 714-41
80. Boecken GH, Lademann M. Complicated malaria tropica - therapy with artemether. Wien Med Wochenschr 1994; 144 (4): 69-73
81. White NJ. Artemisinin: current status. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S3-4
82. Li GQ, Guo XB, Jin R, et al. Clinical studies on treatment of cerebral malaria with qinghaosu and its derivatives. J Tradit Chin Med 1982; Jun; 2 (2): 125-30
83. Guo X, Fu L, Fan T. Thirty three patients with cerebral malaria treated with intravenous artesunate. In: Li G, Guo X, Fu Y, editors. Clinical trials on qinghaosu and its derivatives (vol. 1). Guangzhou: Guangzhou College of Traditional Chinese Medicine, Sanya Tropical Medicine Institute, 1990: 59-63
84. Hien TT, Phu NH, Mai NT, et al. An open randomized comparison of intravenous and intramuscular artesunate in severe falciparum malaria. Trans R Soc Trop Med Hyg 1992; 86 (6): 584-5
85. Wilairatana P, Looareesuwan S. APACHE II scoring for predicting outcome in cerebral malaria. J Trop Med Hyg 1995; 98 (4): 256-60
86. Karbwang J, Sukontason K, Rimchala W, et al. Preliminary report: a comparative clinical trial of artemether and quinine in severe falciparum malaria. Southeast Asian J Trop Med Public Health 1992; 23 (4): 768-72
87. Karbwang J, Tin T, Rimchala W, et al. Comparison of artemether and quinine in the treatment of severe falciparum malaria in south-east Thailand. Trans R Soc Trop Med Hyg 1995; 89 (6): 668-71
88. Hien TT, Arnold K, Vinh H, et al. Comparison of artemisinin suppositories with intravenous artesunate and intravenous quinine in the treatment of cerebral malaria. Trans R Soc Trop Med Hyg 1992; 86 (6): 582-3
89. Taylor TE, Wills BA, Kazembe P, et al. Rapid coma resolution with artemether in Malawian children with cerebral malaria. Lancet 1993; 341 (8846): 661-2
90. Hien TT, Day NP, Nguyen HP, et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N Engl J Med 1996; 335 (2): 76-83
91. Looareesuwan S, Wilairatana P, Vanijanonta S, et al. Efficacy and tolerability of a sequential, artesunate suppository plus mefloquine, treatment of severe falciparum malaria. Ann Trop Med Parasitol 1995; 89 (5): 469-75
92. Looareesuwan S, Wilairatana P, Vanijanonta S, et al. A comparative clinical trial of sequential treatments of severe malaria with artesunate suppository followed by mefloquine in Thailand. Am J Trop Med Hyg. In press
93. Duc DD, de Vries PJ, Nguyen XK, et al. The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. Am J Trop Med Hyg 1994; 51 (6): 785-90
94. Navaratnam V, Mansor SM, Chin LK, et al. Determination of artemether and dihydroartemisinin in blood plasma by high-performance liquid chromatography for application in clinical pharmacological studies. J Chromatogr B Biomed Appl 1995; 669 (2): 289-94
95. Kager PA, Schultz MJ, Zijlstra EE, et al. Arteether administration in humans: preliminary studies of pharmacokinetics, safety and tolerance. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S53-4
96. Edwards G. Measurement of artemisinin and its derivatives in biological fluids. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S37-9
97. Teja-Isavadharm P, Nosten F, Kyle DE, et al. Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: use of simultaneous measurement by high performance liquid chromatography and bioassay. Br J Pharmacol 1996; 42: 599-604
98. Looareesuwan S, Viravan C, Vanijanonta S, et al. Randomized trial of mefloquine-doxycycline, and artesunate-doxycycline for treatment of acute uncomplicated falciparum malaria. Am J Trop Med Hyg 1994; 50 (6): 784-9
99. Phillips Howard PA, ter Kuile FO. CNS adverse events associated with antimalarial agents: fact or fiction? Drug Saf 1995; 12 (6): 370-83
100. Wesche DL, DeCoster MA, Tortella FC, et al. Neurotoxicity of artemisinin analogs in vitro. Antimicrob Agents Chemother 1994; 38 (8): 1813-9
101. Brewer TG, Grate SJ, Peggins JO, et al. Fatal neurotoxicity of arteether and artemether. Am J Trop Med Hyg 1994; 51 (3): 251-9
102. Brewer TG, Peggins JO, Grate SJ, et al. Neurotoxicity in animals due to arteether and artemether. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S33-6
103. Looareesuwan S. Overview of clinical studies on artemisinin derivatives in Thailand. Trans R Soc Trop Med Hyg 1994; 88 Suppl. 1: S9-11
104. Lackritz EM, Campbell CC, Ruebush TK, et al. Effect of blood transfusion on survival among children in a Kenyan hospital. Lancet 1992; 349: 524-8
105. Looareesuwan S, Phillips RE, Karbwang J, et al. Plasmodium falciparum hyperparasitaemia: use of exchange transfusion in seven patients and a review of the literature. Q J Med 1990; 75 (277): 471-81
106. Warrell DA, White NJ, Warrell MJ. Dexamethasone deleterious in cerebral malaria [letter]. BMJ (Clin Res Ed) 1982; 285 (6355): 1652
107. Wyler DJ. Malaria chemoprophylaxis for the traveler. N Engl J Med 1993; 329 (1): 31-7
108. Nyirjesy P, Kavasya T, Axelrod P, et al. Malaria during pregnancy: neonatal morbidity and mortality and the efficacy of chloroquine chemoprophylaxis. Clin Infect Dis 1993; 16 (1): 127-32
109. Nosten F, ter Kuile F, Maelankiri L, et al. Mefloquine prophylaxis prevents malaria during pregnancy: a double-blind, placebo-controlled study. J Infect Dis 1994; 169 (3): 595-603
110. Nosten F, Karbwang J, White NJ, et al. Mefloquine antimalarial prophylaxis in pregnancy: dose finding and pharmacokinetic study. Br J Clin Pharmacol 1990; 30 (1): 79-85
111. Greenwood BM, Greenwood AM, Bradley AK, et al. Comparison of two strategies for control of malaria within a primary health care programme in the Gambia. Lancet 1988; 1 (8595): 1121-7
112. Shanks GD. Malaria prevention and prophylaxis. Baillieres Clin Infect Dis 1995; 2 (2): 331-49
113. Beadle C, Hoffman SL. History of malaria in the United States Naval Forces at war: World War I through the Vietnam conflict. Clin Infect Dis 1993; 16 (2): 320-9
114. Olliaro P, Cattani J, Wirth D. Malaria, the submerged disease. JAMA 1996; 275 (3): 230-3
115. Patz JA, Epstein PR, Burke TA, et al. Global climate change and emerging infectious diseases. JAMA 1996; 275 (3): 217-23
116. Hoffman SL. Artemether in severe malaria - still too many deaths. N Engl J Med 1996; 335 (2): 124-6