Altered biochemical profile and gene expression in aflatoxin B1-transformed C3H10T1/2 cells

International Journal of Oncology

Volumn 10, Issue 6, 1997, Pages 1265-1275

  Nadadur, Srikanth S ^a   Lisciandro, Kelly ^a   Mudipalli, Anuradha ^a   Maccubbin, Alexander E ^a   Faletto, Michael B ^a,b   Gurtoo, Hira L ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Aflatoxin B1; Benzo(a)pyrene; Epoxide hydrolase; Gene rearrangement; Mdr p glycoprotein; MRNA differential expression; P53; Ras oncogene; Solution hybridization; SSCP; Subtractive cDNA library

Indexed keywords

AFLATOXIN B1; COMPLEMENTARY DNA; PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; DNA HYBRIDIZATION; GENE MUTATION; GENE REARRANGEMENT; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SOUTHERN BLOTTING;

EID: 0031002870     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.10.6.1265     Document Type: Article

References (4)

1. Eaton DL and Groopman JD (eds): The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance. Academic Press, San Diego, CA, 1994.
2. 1 carcinogenicity. Proc Soc Exp Biol Med 208: 213-227, 1995.
3. Bressac B, Kew M, Wands J and Ozturk M: Selective G to T mutations of p53 gene in hepatocellular carcinoma from Southern Africa. Nature 350: 429-431, 1991.
4. Scorsone KA, Zhou YZ, Butel JS and Slagle BL: P53 mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinoma from China. Cancer Res 52: 1635-1638, 1992.