The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 3, 1997, Pages 1406-1414

  Mayer, Lawrence D ^a   Dougherty, Graeme ^b   Harasym, Troy O ^b   Bally, Marcel B ^b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CHOLESTEROL; DISTEAROYLPHOSPHATIDYLCHOLINE; DOXORUBICIN; LIPOSOME; MACROGOL; PHOSPHATIDYLETHANOLAMINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG FORMULATION; DRUG UPTAKE; ENCAPSULATION; FEMALE; FIBROSARCOMA; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; DRUG CARRIERS; FEMALE; FIBROSARCOMA; LIPOSOMES; MACROPHAGES; MICE; MICE, INBRED C3H;

EID: 0031002490     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. BALLY, M. B., MASIN, D., NAYAR, R., CULLIS, P. R. AND MAYER, L. D.: Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumour-bearing mice. Cancer Chemother. Pharmacol. 34: 137-146, 1994.
2. COWENS, J. W., CREAVEN, P. J., GRECO, W. R., BRENNER, D. E., TUNG, Y., OSTRO, M., PILKIEWIGZ, F., GINSBERG, R. S. AND PETRELLI, N.: Initial clinical (phase I) trial of TLC D-99 (doxorubicin encapsulated in liposomes). Cancer Res. 53: 2796-2802, 1993.
3. GABIZON, A.: Liposomal Anthracyclines: Facing the clinical challenge. J. Liposome Res. 4: 445-454, 1994.
4. GABIZON, A. AND PAPHADJOPOULOS, D.: Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumours. Proc. Natl Acad. Sci. U.S.A. 85: 6949-6953, 1988.
5. GABIZON, A., DAGAN, A., GOREN, D., BARENHOLZ, Y. AND FUKS, Z.: Liposomes in vivo as carriers of Adriamycin: reduced cardiac uptake and preserved antitumour activity in mice. Cancer Res. 42: 4734-4739, 1982.
6. GABIZON, A., GOREN, D., FUKS, Z., MESHORER, A. AND BARENHOLZ, Y.: Superior therapeutic activity of liposome-associated Adriamycin in a murine metastatic tumour model. Br. J. Cancer 51: 681-689, 1985.
7. GABIZON, A., SHIOTA, R. AND PAPHADJOPOULOS, D.: Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable liposomes with long circulation times. J. Natl. Cancer Inst. 81: 1484-1488, 1989.
8. HOWIE, S., MCBRIDE, W. H. AND JAMES, K.: Distribution of IgM, IgA and IgG secreting cells in the tissues of normal and tumour bearing mice. Immunology 46: 43-48, 1982.
9. HUANG, S. K., LEE, K. D., HONG, K., FRIEND, D. S. AND PAPHADJOPOULOS, D.: Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res. 52: 5135-5143, 1992a.
10. HUANG, S. K., MAYHEW, E., GILANI, S., LASIC, D. D., MARTIN, F. J. AND PAPAHADJOPOULOS, D.: Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma. Cancer Res. 52: 6774-6781, 1992b.
11. HUANG, S. K., STAUFFER, P. R., HONG, K., Guo, J. W. H., PHILLIPS, T. L., HUANG, A. AND PAPAHADJOPOULOS, D.: Liposome hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin of sterically stabilized liposomes. Cancer Res. 54: 2186-2191, 1994.
12. MAYER, L. D., BALLY, M. B., CULLIS, P. R., WILSON, S. L. AND EMERMAN, J. T.:. Comparison of free and liposome encapsulated doxorubicin tumour drug uptake and antitumour efficacy in the SC115 murine mammary tumour. Cancer Lett. 53: 183-190, 1990a.
13. MAYER, L. D., BALLY, M. B. AND CULLIS, P. R.: Strategies for optimizing liposomal doxorubicin. J. Liposome Res. 1: 462-480, 1990b.
14. MAYER, L. D., CULLIS, P. R. AND BALLY, M. B.: The use of transmembrane pH gradient-driven drug encapsulation in the pharmacodynamic evaluation of liposomal doxorubicin. J. Liposome Res. 4: 529-553, 1994.
15. MAYER, L. D., HOPE, M. J. AND CULLIS, P. R.: Vesicles of variable size produced by a rapid extrusion procedure. Biochim. Biophys. Acta 858: 161-168, 1986.
16. MAYER, L. D., HOPE, M, J., CULLIS, P. R. AND JANOFF, A. S.: Solute distribution and trapping efficiencies observed in freeze-thawed multilamellar vesicles. Biochim. Biophys. Acta 817: 93-196, 1985.
17. MAYER, L. D., TAI, L. C. L., KO, D. S. C., MASIN, D., GINSBERG, R. S., CULLIS, P. R. AND BALLY, M. B.: Influence of vesicle size, lipid composition and drug to lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res. 49: 5922-5930, 1989.
18. O'DAY, S. J., MAZANET, R., SKARIN, A. T., SALGIA, R., GORDON, D. AND ELIAS, A. D.: Dose escalation of liposome-encapsulated doxorubicin (D-99) with granulocyte colony stimulating factor (G-CSF) support in patients with advanced malignancies. Proc. Am. Assoc. Clin. Oncol. 13: 153, 1994.
19. PARR, M. J., BALLY, M. B. AND CULLIS, P. R.: The presence of GM1 in liposomes with entrapped doxorubicin does not prevent RES blockade. Biochim. Biophys. Acta 1168: 249-252, 1993.
20. STORM, G., STEERENBER, P. A., EMMEN, F., VAN BORSSUM, W. M. AND CROMMELIN, D. J.: Release of doxorubicin from peritoneal macrophages exposed in vivo to doxorubicin-containing liposomes. Biochim. Biophys. Acta 965: 136-145, 1988.
21. UZIELY, B., JEFFERS, S., ISACSON, R., KUTSCH, K., WEI-TSAO, D., YEHOSHUO, Z., LIBSON, E., MUGGIN, F. M. AND GABIZON, A.: Liposomal doxorubicin: antitumour activity and unique toxicities during two complementary phase I studies. J. Clin. Oncol. 13: 1777-1785, 1995.
22. WORKING, P. K., NEWMAN, M. S., HUANG, S. K., MAYHEW, E., VAAGE, J. AND LASIC, D. D.: Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth liposomes (Doxil). J. Liposome Res. 4: 667-688, 1994.
23. Wu, N. Z., DA, D., RUDOLL, T. L., NEEDHAM, D., WHORTON, A. R. AND DEWHIRST M. W.: Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumour tissue. Cancer Res. 53: 3765-3770, 1993.
24. YUAN, F., LEUNIG, M., HUANG, S. K., BERK, D. A., PAPAHADJOPOULOS, D. AND JAIN, R. K.: Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumour xenograft. Cancer Res. 54: 3352-3356, 1994.