Electrophysiologic effects of nibentan (HE-11) on canine cardiac tissue

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 3, 1997, Pages 1137-1146

  Anyukhovsky, Evgeny P ^a   Sosunov, Eugene A ^a   Rosen, Michael R ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; ISOPRENALINE; NIBENTAN; SOTALOL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG MECHANISM; DRUG SPECIFICITY; HEART ATRIUM; HEART AUTOMATICITY; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART VENTRICLE; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER MEMBRANE POTENTIAL;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZAMIDES; DOGS; HEART; MEMBRANE POTENTIALS;

EID: 0031002489     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. ANDERSON, K. P., WALKER, R., DUSTMAN, T., LUX, R. L., ERSHLER, P. R., KATES, R. E. AND URIC, P. M.: Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo. Circulation 79: 948-958, 1989.
2. ANYUKHOVSKY, E. P. AND ROSEN, M. R.: Electrophysiologic effects of alprafenone on canine cardiac tissue. J. Cardiovasc. Pharmacol. 24: 411-419, 1994.
3. BRACHMAN, J., SCHERLAG, B. J., ROSENSHTRAUKH, L. V. AND LAZZARA, R.: Brady-cardia-dependent triggered activity: Relevance to drug-induced multiform ventricular tachycardia. Circulation 68: 846-856, 1983.
4. CARMELIET, E.: Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers. J. Pharmacol. Exp. Ther. 232: 817-825, 1985.
5. CARMELIET, E.: Mechanisms and control of repolarization. Eur. Heart J. 14: suppl H, 3-13, 1993.
6. COHEN, I. S., DATYNER, N. B., GINTANT, G. A. AND KLINE, R. P.: Time-dependent outward currents in the heart. In The Heart and Cardiovascular System -Scientific Foundations, ed. by H. A. Fozzard, E. Haber, R. B. Jennings, A. M. Katz, H. E. Morgan, pp. 637-669, Raven Press New York, 1986.
7. + channel blockers and activators in cardiac arrhythmias. Cardiovasc. Drug Rev. 7(3): 199-209, 1989.
8. CORABOEUF, E., DEROUBAIX, E. AND COULOMBE, A.: Effect of tetrodotoxin on action potentials of the conducting system in the dog heart. Am. J. Physiol. 236: H561-H567, 1979.
9. FUNCK-BRENTANO, C.: Rate-dependence of class III actions in the heart. Fundam. Clin. Pharmacol. 7: 51-59, 1993.
10. GALLAGHER, J. D., BIANCHI, J. AND GESSMAN, L. J.: A comparison of the electrophysiologic effects of acute and chronic amiodarone administration on canine Purkinje fibers. J. Cardiovasc. Pharmacol. 13: 723-729, 1989.
11. GILES, W. R. AND IMAIZUMI, Y.: Comparison of potassium currents in rabbit atrial and ventricular cells. J. Physiol. (Lond.) 405: 123-145, 1988.
12. GILL, J., HEEL, R. C. AND FITTON, A.: Amiodarone. An overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias. Drugs 43: 69-110, 1992.
13. GWILT, M., DALRIMPLE, H. W., BURGES, R. A., BLACKBURN, K. J., DICKINSON, R. P., CROSS, P. E. AND HIGGINS, A. J.: Electrophysiologic properties of UK-66,914, a novel class III antiarrhythmic agent. J. Cardiovasc. Pharmacol. 17: 376-385, 1991.
14. HAUSWIRTH, O., NOBLE, D. AND TSIEN, R. W.: The dependence of plateau currents in cardiac Purkinje fibers on the interval between action potentials. J. Physiol. (Lond) 222: 27-49, 1972.
15. HONDEGHEM, L. M. AND SNYDERS, D. J.: Class III antiarrhythmic drugs have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use-dependence. Circulation 81: 686-690, 1990.
16. HUME, J. R. AND UEHARA, A.: Ionic basis of the different action potential configuration of single guinea-pig atrial and ventricular myocytes. J. Physiol. (Lond.) 368: 525-544, 1985.
17. + current by dofetilide. Circ. Res. 72: 75-83, 1993.
18. KATRITIS, D. AND CAMM, A. J.: New class III antiarrhythmic drugs. Eur. Heart J. 14: suppl. H, 93-99, 1993.
19. max. Br. J. Pharmacol. 103: 1568-1572, 1991.
20. KODAMA, I., SUZUKI, R., KAMIYA, K., IWATA, H. AND TOYAMA, J.: Effects of longterm oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle. Br. J. Pharmacol. 107: 502-509, 1992.
21. + current in guinea pig ventricular cells. J. Pharmacol. Exp. Ther. 262: 99-108, 1992.
22. LITOVSKY, S. H. AND ANTZELEVITCH, C.: Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry? Circulation 87: 562-572, 1993.
23. MANLEY, B. S., ALEXOPOULOS, D., ROBINSON, G. J. AND LUCCHESI, B. R.: Subsidiary class III effects of beta-blockers? A comparison of atenolol, metoprolol, nadolol, oxprenolol and sotalol. Cardiovasc. Res. 20: 705-709, 1985.
24. MAYKOV, E. B., BAKALOV, S. A., KRUTANOV, I. B., GOLITSIN, S. P., RUDA, M. YA., RUSENSHTRAUKH, L. V. AND CHAZOV, YE. I.: Pilot experience in investigation of electrophysiological and antiarrhythmic effects of nibentan in patients with paroxysmal tachyarrhythmias (Rus). Kardiologiya 5: 10-18, 1995.
25. MAYKOV, E. B., BAKALOV, S. A., KRUTANOV, I. B., GOLITSIN, S. P., RUDA, M. YA., ROSENSHTRAUKH, L. V. AND CHAZOV, YE. I.: Electrophysiological and antiarrhythmic effects of a new class III antiarrhythmic drug nibentan in patients with paroxysmal supraventricular tachyarrhythmias (Rus). Kardiologiya 6: 38-51, 1996.
26. RODEN, D. M. AND HOFFMAN, B. F.: Action potential prolongation and induction of abnormal automaticity by low quinidine concentration in canine Purkinje fibers: Relationship to potassium and cycle length. Circ. Res. 56: 857-867, 1985.
27. ROSEN, M. R., GELBAND, H. AND HOFFMAN, B. F.: Effects of blood perfusion on electrophysiologic properties of isolated canine Purkinje fibers. Circ. Res. 30: 575-588, 1972.
28. ROSENSHTRAUKH, L. V., ANYUKHOVSKY, E. P., BELOSHAPKO, G. G., YUSHMANOVA, A. V., NESTERENKO, V. V., BOGDANOV, K. YU., ZAKHAROV, S. I., GOLOVINA, V. A., GOLITSIN, S. P., RUDA, M. YA. AND CHAZOV, YE. I.: Electrophysiological aspects of cardiac action of a new antiarrhythmic drug nibentan: Experimental study (Rus). Kardiologiya, 5: 25-36, 1995.
29. RUDA, M. YA., MERKULOVA, I. N., TARARAK, A. E., DRAGNEV, A. G., GOLITSIN, S. P., ROZENSHTRAUKH, L. V. AND CHAZOV, E. I.: Clinical study of nibentan - new class III antiarrhythmic drug. II. Efficacy in patients with supraventricular tachyarrhythmias (Rus). Kardiologiya 6: 28-37, 1996.
30. + current: Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 96: 194-214, 1990.
31. SANGUINETTI, M. C., JURKIEWICZ, N. K., SCOTT, A. AND SIEGL, P. K. S.: Isoproterenol antagonizes prolongation of refractory period by class III antiarrhythmic agent E-4031 in guinea pig myocytes. Circ. Res. 68: 77-84, 1991.
32. SHIMONI, Y., CLARK, R. B. AND GILES, W. R.: Role of an inwardly rectifying potassium current in rabbit ventricular action potential. J. Physiol. (Lond.) 448: 709-727, 1992.
33. SOSUNOV, E. A., ANYUKHOVSKY, E. P. AND ROSEN, M. R.: Chronic in vivo and in vitro effects of amiodarone on guinea pig hearts. J. Pharmacol. Exp. Ther. 278: 906-912, 1996.
34. TALAJIC, M., NATTEL, S., DEVIS, M. AND MCCANS, J.: Attenuation of class 3 and sinus node effects of amiodarone by experimental hypothyroidism. J. Cardiovasc. Pharmacol. 13: 447-450, 1989.
35. TASK FORCE OF THE WORKING GROUP ON ARRHYTHMIAS OF THE EUROPEAN SOCIETY OF CARDIOLOGY: The Sicilian gambit. Circulation 84: 1831-1851, 1991.
36. UNGER, J., LAMBERT, M., JONCKHEER, M. H. AND DENAYER, P. H.: Amiodarone and the thyroid: Pharmacological, toxic and therapeutic effects. J. Int. Med. 233: 435-443, 1993.
37. WINER, B. G., BROWN, D. R. AND MICHELS, K. M.: Statistical Principles in Experimental Design, McGraw-Hill, Inc., New York, 1991.
38. WYSE, K. R., YE, V. AND CAMPBELL, T. J.: Action potential prolongation exhibits simple dose-dependence for sotalol, but reverse dose-dependence for quinidine and disopyramide: Implications for proarrhythmia due to triggered activity. J. Cardiovasc. Pharmacol. 21: 316-322, 1993.
39. YABEK, S. M., KATO, R., IKEDA, N. AND SINGH, B. N.: Effects of flecainide on the cellular electrophysiology of neonatal and adult cardiac fibers. Am. Heart J. 113: 70-76, 1987.
40. YAZAWA, K. AND KAMEYAMA, M.: Mechanism of receptor-mediated modulation of the delayed outward potassium current in guinea pig ventricular myocytes. Am. J. Physiol. 428: 135-150, 1990.
41. YUSUF, S. AND TEO, K. K.: Approaches to prevention of sudden death: Need for fundamental re-evaluation. J. Cardiovasc. Electrophysiol. 2(3): S233-S239, 1991.
42. ZAZA, A., MALFATTO, G. AND ROSEN, M. R.: Electrophysiologic effects of ketanserin on canine Purkinje fibers, ventricular myocardium and the intact heart. J. Pharmacol. Exp. Ther. 250: 397-405, 1989.