Effect of progressive incremental exercise and β-adrenergic blockade on erythrocyte ion concentrations

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 1, 1997, Pages 19-25

  McKelvie, Robert S ^a,b   Jones, N L ^a   Heigenhauser, G J F ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b HAMILTON GENERAL HOSPITAL   (Canada)

Author keywords

Hydrogen ion; Ion movement; Lactate; Potassium; Red cell volume

Indexed keywords

LACTIC ACID; POTASSIUM; PROPRANOLOL;

ADULT; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BICYCLE ERGOMETRY; BLOOD ANALYSIS; CELL VOLUME; CONTROLLED STUDY; ERYTHROCYTE; EXERCISE TEST; HEART RATE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LACTATE BLOOD LEVEL; MALE; MEAN CORPUSCULAR VOLUME; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OXYGEN CONSUMPTION; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL;

EID: 0031001307     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y96-153     Document Type: Article

References (35)

1. Bodemann, H.H., Irmer, M., Schliuter, K.J., Reininghaus, M., and Keul, J. 1987. Activation of sodium transport in human erythrocytes by beta-adrenoceptor stimulation in vivo. Eur. J. Appl. Physiol. 56: 375-380.
2. Boning, D., Tibes, U., and Schweigart, U. 1976. Red cell hemoglobin, hydrogen ion and electrolyte concentrations during exercise in trained and untrained subjects. Eur. J. Appl. Physiol. 35: 243-249.
3. Brugnara, C., Van Ha, T., and Tosteson, D.C. 1989. Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cells. Am. J. Physiol. 256: C994-C1003.
4. Buono, M.J., and Faucher, P.E. 1985. Intraerythrocyte and plasma osmolality during graded exercise in humans. J. Appl. Physiol. 58: 1069-1072.
5. Buono, M.J., and Yeager, J.E. 1986. Intraerythrocyte and plasma lactate concentrations during exercise in humans. Eur. J. Appl. Physiol. 55: 326-329.
6. Canessa, M., Brugnara, C., Cusi, D., and Tosteson, D.C. 1986. Modes of operation and variable stoichiometry of the furosemide-sensitive Na and K-fluxes in human red cells. J. Gen. Physiol. 87: 113-142.
7. Carlsson, E., Fellenius, E., Lundborg, P., and Svensson, L. 1978. β-Adrenoceptor blockers, plasma potassium, and exercise. Lancet, ii: 424-425.
8. + homeostasis. Acta Med. Scand. Suppl. 672: 111-115.
9. + transport in skeletal muscle. Physiol. Rev. 66: 542-580.
10. 2 blockade on exercise endurance and muscle metablism in humans. J. Appl. Physiol. 66(2): 548-554.
11. Decker, D.G., and Rosenbaum, J.D. 1942. The distribution of lactic acid in human blood. Am. J. Physiol. 138: 7-11.
12. Deuticke, B. 1982. Monocarboxylate transport in erythrocytes. J. Membr. Biol. 70: 89-103.
13. Deuticke, B., Beyer, E., and Forst, B. 1982. Discrimination of three parallel pathways of lactate transport in the human erythrocyte membrane by inhibitors and kinetic properties. Biochim. Biophys. Acta, 684: 96-110.
14. Dubinsky, W.P., and Racker, E. 1978. The mechanism of lactate transport in human erythrocytes. J. Membr. Biol. 44: 25-36.
15. Greenleaf, J.E., Convertino, V.A., and Mangseth, G.R. 1979. Plasma volume during stress in man: osmolality and red cell volume. J. Appl. Physiol. 47: 1031-1038.
16. Harris, R.T., and Dudley, G.A. 1989. Exercise alters the distribution of ammonia and lactate in blood. J. Appl. Physiol. 66: 313-317.
17. Harrison, M.H. 1985. Effects of thermal stress and exercise on blood volume in humans. Physiol. Rev. 65: 149-209.
18. Hespel, P., Lijnen, P., Fiocchi, R., Denys, B., Lissens, W., M'Buyamba-Kabangu, J.R., and Avery, A. 1986a. Cationic concentrations and transmembrane fluxes in erythrocytes of humans during exercise. J. Appl. Physiol. 61: 37-43.
19. +-ATPase pump activity in athletes and sedentary subjects. Eur. J. Appl. Physiol. 55: 24-29.
20. Hoffman, J.F., Yingst, D.R., Goldfinger, J.M., Blum, R.M., and Knauf, P.A. 1980. On the mechanism of Ca-dependent K-transport in human red blood cells. In Membrane transport in erythrocyte relations between function and molecular structure. Edited by W.V. Lassen, H.H. Ussing, and J.O. Weith. Munksgaard, Copenhagen. pp. 179-192.
21. Hoffmann, E.K., and Simonsen, L.O. 1989. Membrane mechanisms in volume and pH regulation of vertebrate cells. Physiol. Rev. 69: 315-382.
22. Hohorst, H.J. 1965. L-(+)-Lactate determination with lactate dehydrogenase and DPN. In Methods of enzymatic analysis. Edited by H.U. Bergmeyer. Academic Press, New York. p. 266.
23. Hughson, R.L., and McFarlane, B.J. 1981. Effect of oral propranolol on the anaerobic threshold and maximum exercise performance in normal man. Can. J. Physiol. Pharmacol. 59: 567-573.
24. + flux in exercising humans. J. Appl. Physiol. 59: 336-341.
25. Kilburn, K.H. 1966. Muscular origin of elevated plasma potassium during exercise. J. Appl. Physiol. 21: 675-678.
26. Lijnen, P., Hespel, P., Fagard, R., Goris, M., Lysens, R., Vanden Eynde, E., and Amery, A. 1989. Effect of prolonged physical exercise on intra-erythrocyte and plasma potassium. Eur. J. Appl. Physiol. 59: 296-302.
27. - distribution in humans during and after high-intensity exercise: role in muscle fatigue attenuation? J. Appl. Physiol. 78(3): 765-777.
28. McKelvie, R.S., and Jones, N.L. 1989. Cardiopulmonary exercise testing. Clin. Chest Med. 10: 277-291.
29. McKelvie, R.S., Jones, N.L., and Heigenhauser, G.J.F. 1991a. Factors contributing to increased muscle fatigue with β-blockers. Can. J. Physiol. Pharmacol. 69: 254-261.
30. McKelvie, R.S., Lindinger, M.I., Heigenhauser, G.J.F., and Jones, N.L. 1991b. Contribution of erythrocytes to the control of the electrolyte changes of exercise. Can. J. Physiol. Pharmacol. 69: 984-993.
31. McKelvie, R.S., Lindinger, M.I., Jones, N.L., and Heigenhauser, G.J.F. 1992. Erythrocyte ion regulation across inactive muscle during leg exercise. Can. J. Physiol. Pharmacol. 70: 1625-1633.
32. Poole, R.C., and Halestrap, A.P. 1993. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 264: C761-C782.
33. Van Beaumont, W., Underkofler, S., and Van Beaumont, S. 1981. Erythrocyte volume, plasma volume, and acid-base changes in exercise and heat dehydration. J. Appl. Physiol. 50: 1255-1262.
34. Williams, M.E., Gervino, E.V., Rosa, R.M., Landsberg, L., Young, J.B., Silva, P., and Epstein, F.H. 1985. Catecholamine modulation of rapid potassium shifts during exercise. N. Engl. J. Med. 312: 823-827.
35. Woodbury, J.W. 1965. The cell membrane: ionic and potential gradients and active transport. In Physiology and biophysics. 19th ed. Edited by T.C. Ruch and H.D. Patton. W.B. Saunders Co., Philadelphia. pp. 1-25.