In vivo study of halothane hepatotoxicity in the rat using magnetic resonance imaging and 31P spectroscopy

Journal of Biochemical and Biophysical Methods

Volumn 34, Issue 2, 1997, Pages 107-122

  Noseworthy, Michael D ^a   Janzen, Edward G ^a   Towner, Rheal A ^a   Yamashiro, S ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Anaesthetic; Halothane; Liver; MRI; MRS; Rat; Toxicity

Indexed keywords

HALOTHANE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INHALATIONAL DRUG ADMINISTRATION; LIVER TOXICITY; MALE; MITOCHONDRION SWELLING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; SMOOTH ENDOPLASMIC RETICULUM; TISSUE WATER; TRANSMISSION ELECTRON MICROSCOPY;

ANESTHETICS, INHALATION; ANIMALS; HALOTHANE; LIVER; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, WISTAR;

EID: 0031001112     PISSN: 0165022X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-022X(97)01207-4     Document Type: Article

References (30)

1. Neuberger, J. and Davis, M., Advances in understanding halothane hepatitis, drug metabolism and distribution. In: J.W. Lamble (Ed.), Biotransformation, Elsevier Biomedical Press, New York, 1983, pp. 126-129.
2. Hall, P.M., Cousins, M.J., Plummer, J.L. and Lunman, C.A., Pathogenic mechanisms for halothane hepatotoxicity in animal models and man. In: Molecular and Cellular Mechanisms of Anesthetics, Plenum Press, New York, 1986, pp. 433-441.
3. Rosenak, D., Halevy, A. and Orda, R., Halothane and liver damage, Postgrad. Med. J., 65 (1985) 129-135.
4. Wright, R., Chisolm, M., Lloyd, B., Edwards, J.C., Eade, O.E., Hawksley, M., Moles, T.M. and Gardner, M.J., Controlled prospective study of the effect on liver function of multiple exposures to halothane, Lancet, i (1975) 817-820.
5. Lunam, C.A., Hall, P.M. and Cousins, M.J., The pathology of halothane hepatotoxicity in a guinea pig model: A comparison with human halothane hepatitis, Br. J. Exp. Pathol., 70 (1989) 533-544.
6. Mallédant, Y., Siproudhis, L., Tanguy, M., Clerc, C., Chesné, C., Saint-Marc, C. and Guillouzo, A., Effects of halothane on human and rat hepatocyte cultures, Anesthesiology, 72 (1990) 526-534.
7. Ghantous, H.N., Fernando, J., Gandolfi, A.J. and Brendel, K., Toxicity of halothane in guinea pig liver slices, Toxicology, 62 (1990) 59-69.
8. Lind, R.C., Gandolfi, A.J., Sipes, I.G., Brown, B.R. and Waters, S.J., Oxygen concentrations required for reductive defluorination of halothane by rat hepatic microsomes, Anesth. Analg., 65 (1986) 835-839.
9. 2 on high energy phosphate levels maintained by isolated rat liver mitochondria, Anesth. Analg., 65 (1986) 1130-1134.
10. Janzen, E.G., Towner, R.A., Krygsman, P.H. and Haire, D.L., Structure identification of free radicals by ESR and GC/MS of PBN spin adducts from the in vitro and in vivo, rat liver metabolism of halothane, Free Radic. Res. Commun., 9 (1990) 343-351.
11. Brauer, M., Towner, R.A., Renaud, I., Janzen, E.G. and Foxall, D.L., In vivo proton nuclear magnetic resonance imaging studies of halocarbon-induced liver damage, Magn. Reson. Med., 9 (1989) 229-239.
12. 4-induced rat liver injury detected by proton magnetic resonance imaging (MRI) in vivo and electron microscopy (EM), Free Radic. Res. Commun., 9 (1990) 325-335.
13. 31P-NMR spectroscopy of rat liver treated with halocarbons, Biochim. Biophys. Acta, 993 (1989) 92-99.
14. Kimmich, R. and Hoepfel, D., Volume selective multipulse spin-echo spectroscopy, J. Magn. Reson., 72 (1986) 379-384.
15. Kay, I. and Henkelman, R.M., Practical implementation and optimization of one-shot T1 imaging, Magn Reson. Med., 22 (1991) 414-424.
16. Bendall, M.R., Foxall, D., Nichols, B.G. and Schmidt, J.R., Complete localization of in vivo NMR spectra using two concentric surface coils and RF methods only, J. Magn. Reson., 70 (1986) 181-186.
17. 31P NMR spectroscopy, Biochim. Biophys. Acta, 885 (1986) 1-11.
18. Gadian, D.G., Nuclear Magnetic Resonance and its Applications to Living Systems. Oxford University Press, New York, 1982.
19. 2+, MgATP, and MgADP in intact Ehrlich ascites tumor cells, Proc. Natl. Acad. Sci. U.S.A., 77 (1980) 2487-2491.
20. Lind, R.C., Gandolfi, A.J., Sipes, J.G. and Brown, B.R., Comparison of the requirements for hepatic injury with halothane and enflurane in rats, Anesth. Analg., 64 (1985) 955-963.
21. Shingu, K., Eger El, I.I. and Johnson B.H., Hypoxia may be more important than reductive metabolism in halothane induced hepatic injury, Anesth. Analg., 61 (1982) 824-827.
22. Stark, D.D., Bass, H.M., Moss, A.A., Bacon, B.R., McKerrow, J.H., Cann, C.E., Brito, A. and Goldberg, H.I., Nuclear magnetic resonance imaging of experimentally induced liver disease, Radiology, 148 (1983) 743-751.
23. Towner, R.A., Reinke, L.A., Janzen, E.G. and Yamashiro, S., Enhancement of carbon tetrachloride-induced liver injury by a single dose of ethanol: proton magnetic resonance imaging (MRI) studies in vivo, Biochim. Biophys. Acta, 1096 (1991) 222-230.
24. 31P NMR spectroscopy, Magn. Reson. Med., 20 (1991) 100-112.
25. Guyton, A.C., Textbook of Medical Physiology, W.B. Saunders, Toronto, 8th edition, 1991, pp. 98-110.
26. 450 monooxygenase system in rat liver lobes, Jpn. J. Pharmacol., 32 (1982) 999-1011.
27. Edelman, R.R., Kleefield, J., Wentz, K.U. and Atkinson, D.J., Basic principles of magnetic resonance imaging. In: R.R. Edelman and J.R. Hesselink (Eds.), Clinical Magnetic Resonance Imaging. W.B. Saunders, Toronto, 1990, pp. 3-38.
28. Marzella, L. and Trump, B.F., Pathology of the liver: Functional and structural alterations of hepatocyte organelles induced by cell injury. In: R.G. Meeks, S.D. Harrison and R.J. Bull (Eds.), Hepatotoxicology. CRC Press, Boca Raton, FL, 1991, pp. 93-138.
29. 2+ concentrations, J. Biol. Chem., 248 (1973) 4811-4819.
30. Garlid, K.D. and Beavis, A.D., Swelling and contraction of the mitochondrial matrix. II. Quantitative application of the light scattering technique to solute transport across the inner membrane, J. Biol. Chem., 260 (1985) 13434-13441.