Tumor therapy with an antibody-targeted superantigen generates a dichotomy between local and systemic immune responses

American Journal of Pathology

Volumn 150, Issue 5, 1997, Pages 1607-1618

  Litton, Mark J ^a,e   Dohlsten, Mikael ^b   Hansson, Johan ^b   Rosendahl, Alexander ^b   Ohlsson, Lennart ^b   Kalland, Terje ^b   Andersson, Jan ^a,c   Andersson, Ulf ^a,d  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d ST GÖRAN S HOSPITAL   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; STAPHYLOCOCCUS ENTEROTOXIN; SUPERANTIGEN; TUMOR NECROSIS FACTOR; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER IMMUNOTHERAPY; GENE TARGETING; IMMUNE RESPONSE; LUNG METASTASIS; LYMPHOCYTIC INFILTRATION; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION;

EID: 0031000834     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Kappler J, Kotzin B, Herron L, Gelfand EW, Bigler RD, Boylston A, Carrel S, Posnett DN, Choi Y, Marrack P: Vβ-specific stimulation of human T cells by staphylococcal toxins. Science 1989, 244:811-813
2. Janeway CJ, Yagi J, Conrad PJ, Katz ME, Jones B, Vroegop S, Buxser S: T-cell responses to Mls and to bacterial proteins that mimic its behavior. Immunol Rev 1989, 107:61-88
3. White J, Herman A, Pullen AM, Kubo R, Kappler JW, Marrack P: The Vβ-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 1989, 56:27
4. Langford MP, Stanton GK, Johnsson HM: Biological effects of staphylococcal enterotoxins A on human peripheral lymphocytes. Infect Immun 1978, 22:62-68
5. Scherer MT, Ignatowicz L, Winslow GM, Kappler JW, Marrack P: Superantigens: Bacterial and viral proteins that manipulate the immune system. Annu Rev Cell Biol 1993, 9:101-128
6. Andersson J, Nagy S, Björk L, Abrams JS, Andersson U, Holm S: Bacterial toxin-induced cytokine production studied at the single cell level. Immunol Rev 1992, 127:69-96
7. Dohlsten M, Sundstedt A, Björklund M, Hedlund G, Kalland T: Superantigen-induced cytokines suppress growth of human colon-carcinoma cells. Int J Cancer 1993, 54:482-488
8. Dhein J, Walczak H, Baumler C, Debatin K-M, Krammer PH: Autocrine T-cell suicide mediated by APO-1/(Fas/ CD95). Nature 1995, 373:438-441
9. Dohlsten M, Abrahmsén L, Björk P, Lando PA, Hedlund G, Forsberg G, Brodin T, Gascoigne NR, Förberg C, Lind P, Kalland T: Monoclonal antibody-superantigen fusion proteins: tumor specific agents for T cell based tumor therapy. Proc Natl Acad Sci USA 1994, 91:8945-8949
10. Dohlsten M, Lando PA, Abrahmsén L, Bjork P, Ohlsson L, Lind P, Kalland T: Immunotherapy of human colon cancer by antibody targeted cytokines. Cancer immunol immunother 1995, 41(3):162-168
11. Dohlsten M, Hansson J, Ohlsson L, Litton MJ, Kalland T: Antibody-targeted superantigens are potent inducers of tumor-infiltrating T lymphocytes in vivo. Proc Natl Acad Sci USA 1995, 92:9791-9795
12. Lando PA, Dohlsten M, Ohlsson L, Kalland T: Tumor-reactive superantigens suppress tumor growth in humanized SCID mice. Int J Cancer 1995, 62:2471-2476
13. Haskins K: The T cell receptor for antigen. Year Immunol 1985, 63:74-79
14. Litton MJ, Sander BS, Murphy E, O'Garra A, Abrams JS: Early Expression of cytokines in lymph nodes after treatment in vivo with SEB. J Immunol Methods 1994, 175:47-58
15. Litton MJ, Dohlsten M, Lando PA, Kalland T, Ohlsson L, Andersson J, Andersson U: Antibody targeted superantigen induces tumor infiltrating lymphocytes, excessive cytokine production, and apoptosis in human colon carcinoma. Eur J Immunol 1996, 26:1-9
16. Takimoto H, Yoshikai Y, Kashihara K, Matsuzaki G, Kuga H, Otani T, Nomoto K: Stimulation of all T cells bearing Vβ1, Vβ3, Vβ11, and Vβ12 by staphylococcal enterotoxin A. Eur J Immunol 1990, 20:617-621
17. Hudson KR, Robinson H, Fraser JD: Two additional residues in staphylococcal enterotoxins A and E determine T cell receptor Vβ specificity. J Exp Med 1993, 177:175-185
18. Rocken M, Urban J, Shevach EM: Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo. J Exp Med 1994, 179:1885-1893
19. Florquin S, Amraoui Z, Goldman M: T cells made deficient in IL-2 production by exposure to SEB in vivo are primed for IFN-γ and IL-10 secretion. Eur J Immunol 1995, 25:1148-1153
20. Paul WE (ed): Fundamental immunology. New York, Raven Press, 1989, p 1123
21. Bette M, Schafer MKH, Rooijen NV, Weihe E, Fleischer B: Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen. J Exp Med 1993, 178:1531-1540
22. Dohlsten M, Bjorklund M, Sundstedt A, Hedlund G, Samson D, Kalland T: Immunopharmacology of the superantigen staphylococcal enterotoxin A in T-cell receptor Vβ3 transgenic mice. Immunology 1993, 79:520-527
23. Beutler B, Cerami A: The biology of cachoxin/TNFα primary mediator of the host response. Annu Rev Immunol 1989, 7:625-655
24. Trede N, Geha RS, Chatila T: Transcriptional activation of monokine genes by MHC class II ligands. J Immunol 1991, 146:2310-2315
25. Mehindate K, Thibodeau J, Dohlsten M, Kalland T, Sekaly R, Mourad W: Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression. J Exp Med 1995, 182:1573-1577
26. Kawabe Y, Ochi A: Selective anergy of Vβ8 T cells by Staphylococcus enterotoxin B-primed mice. J Exp Med 1990, 172:1065-1070
27. MacDonald HR, Baschieri S, Lees RK: Clonal expansion precedes anergy and death of Vβ8 peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur J Immunol 1991, 21:1963-1966
28. + cells to bacterial superantigens. Eur J Immunol 1992, 22:1935-1938
29. Sundstedt A, Dohlsten M, Hedlund G, Hoiden I, Bjorklund M, Kalland T: Superantigens energize cytokine production but not cytotoxicity in vivo. Immunology 1994, 82:117-125
30. + T cells. J Immunol 1995, 154:6306-6313
31. Rice GE, Bevilacqua MP: An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science 1989, 246:1303-1306
32. Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S: T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1β. Nature 1993, 361:79-82
33. Sakurai M, Iigo M, Tamura T, Otsu A, Sasaki Y, Nakano H, Nakagawa K, Minato K, Ohe Y, Saijo N: Comparative study of the antitumor effect of two types of murine recombinant interferons, (β) and (γ), against B16-F10 melanoma. Cancer Immunol Immunother 1988, 26:109-113