Down regulation of intimin expression during attaching and effacing enteropathogenic Escherichia coli adhesion

Infection and Immunity

Volumn 65, Issue 5, 1997, Pages 1644-1652

  Knutton, Stuart ^a   Adu Bobie, Jeannette ^b   Bain, Christopher ^a   Phillips, Alan D ^c   Dougan, Gordon ^b   Frankel, Gad ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN;

ARTICLE; BACTERIAL GROWTH; BACTERIUM ADHERENCE; DOWN REGULATION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INTESTINE MUCOSA; PRIORITY JOURNAL;

EID: 0031000799     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.5.1644-1652.1997     Document Type: Article

References (33)

1. Adu-Bobie, J., G. Frankel, S. Knutton, G. Douce, and G. Dougan. Unpublished data.
2. Cravioto, A., R. J. Gross, S. M. Scotland, and B. Rowe. 1979. An adhesive factor found in strains of Escherichia coli belonging to the traditional infantile enteropathogenic serogroups. Curr. Microbiol. 3:95-99.
3. Donnenberg, M. S., S. B. Calderwood, A. Donohue-Rolfe, G. T. Keusch, and J. B. Kaper. 1990. Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells. Infect. Immun. 58:1565-1571.
4. Donnenberg, M. S., and J. B. Kaper. 1991. Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect. Immun. 59:4310-4317.
5. Donnenberg, M. S., and J. B. Kaper. 1992. Enteropathogenic Escherichia coli. Infect. Immun. 60:3953-3961.
6. Donnenberg, M. S., C. O. Tacket, S. P. James, G. Losonsky, J. B. Nataro, S. S. Wasserman, J. B. Kaper, and M. M. Levine, 1993. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection, J. Clin. Invest 92:1412-1417.
7. Donnenberg, M. S., J. Yu, and J. B. Kaper. 1993. A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells. J. Bacteriol. 175:4670-4680.
8. Foubister, V., I. Rosenshine, M. S. Donnenberg, and B. B. Finlay. 1994. The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells. Infect. Immun. 62:3038-3040.
9. Frankel, G., D. C. A. Candy, P. Everest, and G. Dougan. 1994. Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Infect. Immun. 62:1835-1842.
10. Frankel, G., D. C. A. Candy, E. Fabiani, J. Adu-Bobie, S. Gil, M. Novakova, A. D. Phillips, and G. Dougan. 1995. Molecular characterization of a carboxy-terminal eukaryotic-cell-binding domain of intimin from enteropathogenic Escherichia coli. Infect. Immun. 63:4323-4328.
11. Girón, J. A., S. Y. Ho, and G. K. Schoolnik. 1991. An inducible bundle-forming pilus of enteriopathogenic Escherichia coli. Science 254:710-713.
12. Gómez-Duarte, O. G., and J. B. Kaper. 1995. A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli. Infect. Immun, 63:1767-1776.
13. Haigh, R., T. J. Baldwin, S. Knutton, and P. H. Williams. 1995. Carbon dioxide regulated secretion of the EaeB protein of enteropathogenic Escherichia coli, FEMS Microbiol. Lett. 129:63-68.
14. Jarvis, K. G., J. A. Giron, A. E. Jerse, T. K. McDaniel, M. S. Donnenberg, and J. B. Kaper 1995. Enteropathogenic Escherichia coli contains a specialised secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc. Natl. Acad. Sci. USA 92:7996-8000.
15. Jerse, A. E., and J. B. Kaper. 1991. The eae gene of enteropathogenic Escherichai coli encodes a 94-kilodalton membrane protein, the expression of which is influenced by the EAF plasmid. Infect. Immun. 59:4302-43109.
16. Jerse, A. E., J. Yu, B. D. Tall, and J. B. Kaper. 1991. A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc Natl. Acad. Sci. USA 87:7839-7843.
17. Kaper, J. B. 1996. Defining EPEC. Rev. Microbiol. Sao Paulo 27(Suppl.):130-133.
18. Kenny, B., and B. B. Finlay. 1995. Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals in epithelial cells. Proc. Natl. Acad. Sci. USA 92:7991-7995.
19. Kenny, B., L. C. Lai, B. B. Finlay, and M. S. Donnenberg. 1996. EspA. a protein secreted by enteropathogenic Escherichia coli (EPEC) is required to induce signals in epithelial cells. Mol. Microbiol. 20:313-323.
20. Knutton, S. 1995. Electron microscopical methods in adhesion. Methods Enzymol. 253:145-158.
21. Knutton, S., M. M. Baldini, J. B. Kaper, and A. S. McNeish. 1987. Role of plasmid-encoded adherence factors in adhesion of enteropathogenic Escherichia coli to HEp-2 cells. Infect. Immun. 55:78-85.
22. Knutton, S., T. Baldwin, P. H. Williams, and A. S. McNeish. 1989. Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli. Infect. Immun. 57:1290-1298.
23. Knutton, S., G. K. Collington, T. J. Baldwin, R. D. Haigh. and P. H. Williams. 1996. Cellular responses to EPEC infection. Rev. Microbiol. Sao Paulo 27(Suppl.):89-94.
24. Knutton, S., D. R. Lloyd, and A. S. McNeish. 1987. Adhesion of enteropathogenic Escherichia coli to human intestinal enterocytes and cultured human intestinal mucosa. Infect. Immun. 55:69-77.
25. Levine, M. M. 1987. Escherichia coli that cause diarrhoea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohaemorrhagic. and enteroadherent. J. Infect. Dis. 155:377-389.
26. Levine, M. M., E. J. Berquist, D. R. Nalin, D. H. Waterman, R. B. Hornick, C. R. Young, S. Stoman. and B. Rowe. 1978. Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasive. Lancet i:119-122.
27. Levine, M. M., J. P. Nataro, H. Karch, M. M. Baldini, J. B. Kaper, R. E. Black, M. L. Clements, and A. D. O'Brien. 1985. The diarrhoeal response of humans to some classic serotypes of enteropathogenic Escherichia coli is dependent on a plasmid encoding an enteroadhesiveness factor. J. Infect. Dis. 152:550-559.
28. McDaniel, T. K., K. G. Jarvis, M. S. Donnenberg, and J. B. Kaper. 1995. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc. Natl. Acad. Sci. USA 92:1664-1668.
29. Puente, J. L., D. Beiber, S. W. Ramer, W. Murray, and G. K. Schoolnik. 1996. The bundle-forming pili of enteropathogenic Escherichia coli: transcriptional regulation by environmental signals. Mol. Microbiol. 20:87-100.
30. Rosenshine, I., S. Ruschowski, and B. B. Finlay. 1996. Expression of attaching/effacing activity by enteropathogenic Escherichia coli depends on growth phase, temperature, and protein synthesis upon contact with epithelial cells. Infect. Immun. 64:966-973.
31. Tobe, T., G. K. Schoolnik, I. Sohel, V. H. Bustamante, and J. L. Puente. 1996. Cloning and characterisation of bfpTVW, genes required for the transcriptional activation of bfpA in enteropathogenic Escherichia coli. Mol. Microbiol. 21:963-975.
32. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
33. Ulshen, M. H., and J. L. Rollo. 1980. Pathogenesis of Escherichia coli gastroenteritis in man - another mechanism. N. Engl. J. Med. 302:99-101.