Glutamate decarboxylase-reactive peripheral blood lymphocytes from patients with IDDM express gut-specific homing receptor α4β7-integrin

Diabetes

Volumn 46, Issue 4, 1997, Pages 583-588

  Paronen, Johanna ^a   Klemetti, Paula ^a   Kantele, Jussi M ^a,b   Savilahti, Erkki ^a   Perheentupa, Jaakko ^a   Åkerblom, Hans K ^a   Vaarala, Outi ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; GLUTAMATE DECARBOXYLASE; INTEGRIN; TETANUS TOXOID;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNITY; CELL SELECTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; FEMALE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; PANCREAS ISLET BETA CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031000729     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.46.4.583     Document Type: Article

References (31)

1. Atkinson MA, Maclaren NK: Islet cell autoantigens in insulin-dependent diabetes. J Clin Invest 92:1608-1616, 1993
2. Picker LJ, Butcher EC: Physiological and molecular mechansims of lymphocyte homing. Annu Rev Immunol 19:561-591, 1992
3. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, Weissman IL, Hamann A, Butcher EC: α4β7 Integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74:185-195, 1993
4. Schweighoffer T, Tanaka Y, Tidswell M, Erle DJ, Horgan KJ, Ginther Luce GE, Lazarovits AI, Buck D, Shaw S: Selective expression of integrin α4β7 on a subset of human C4+ memory T cells with hallmarks of gut-trophism. J Immunol 151:717-729, 1993
5. Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M: Expression and function of the MAdCAM-1 receptor, integrin α4β7, on human leukocytes. J Immunol 153:517-528, 1994
6. Hänninen A, Taylor C, Streeter PR, Stark LS, Sarte JM, Shiruzu JA, Simell O, Michie SA: Vascular addressins are induced on islet vessels during insulitis in non-obese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest 92:2509-2515, 1993
7. Faveeuw C, Gagnerault M-C, Lepault F: Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of non-obese diabetic mice. J Immunol 152:5969-5978, 1994
8. Yang XD, Michie SA, Tisch R, Karin N, Steinman L, McDevitt HO: A predominant role of integrin α4 in the spontaneous development of autoimmune diabetes in non-obese diabetic mice. Proc Natl Acad Sci USA 91:12604-12608, 1994
9. Virtanen SM, Räsänen L, Ylönen K, Aro A, Clayton D, Langholz B, Pitkäniemi J, Savilahti E, Lounamaa R, Tuomilehto J, Åkerblom HK, The Childhood Diabetes in Finland (DiMe) Study Group: Early introduction of dairy products associated with increased risk of IDDM in Finnish children. Diabetes 42:1786-1790, 1993
10. Hyöty H, Hiltunen M, Knip M, Laakkonen M, Vähäsalo P, Karjalainen J, Koskela P, Roivainen M, Leinikki P, Hovi T, Åkerblom HK, the Childhood Diabetes in Finland (DiMe) Study Group: A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Diabetes 44:652-657, 1995
11. Savilahti E, Åkerblom HK, Tainio V-M, Koskimies S: Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res 7:137-140, 1988
12. Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Åkerblom HK, Dosch H-M: A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327:302-307, 1992
13. Vaarala O, Klemetti P, Savilahti E, Reijonen H, Ilonen J, Åkerblom HK: Enhanced cellular immune response to cow milk β-lactoglobulin in patients with newly diagnosed IDDM. Diabetes 45:178-182, 1996
14. Aaltonen J, Björses P, Sandkijl L, Perheentupa J, Peltonen L: An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type 1 assigned to chromosome 21. Nat Genet 8:83-87, 1994
15. Moody AJ, Hejnaes KR, Marshall M, Larsen RS, Boel E, Svendsen I, Mortensen E, Dyrberg T: Isolation by anion-exchange of immunologically and enzymatically active human islet glutamic acid decarboxylase 65 overexpressed in Sf9 insect cells. Diabetologia 38:14-23, 1995
16. Lazarovits AI, Moscicki RA, Kurnick J, Camerini D, Bhan AK, Baird LG, Erikson M, Colvin RB: Lymphocyte activation antigens I: a monoclonal antibody, Act-I, defines a new late lymphocyte activation antigen. J Immunol 133:1857-1862, 1984
17. Harrison LC, Honeyman MC, DeAizpura HJ, Schmidli RS, Colman PG, Tait BD, Cram DS: Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341:1365-1369, 1993
18. Hagopian WA, Sanjeevi CB, Kockum I, Landin-Olsson M, Karlsen AE, Sundkvist G, Dahlquist G, Palmer J, Lernmark Å: Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95:1505-1511, 1995
19. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GSP, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69-72, 1993
20. Tisch R, Yang X-D, Singer SM, Liblau RS, Fugger L, McDevitt HO: Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366:72-75, 1993
21. Baron J, Reich E-P, Visintin I, Janeway CA Jr. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between α4-integrins and vascular cell adhesion molecule-1. J Clin Invest 93:1700-1708, 1994
22. Jakubowski A, Newman Ehrenfels B, Pepinsky RB, Burkly LC: Vascular cell adhesion molecule-Ig fusion protein selectively targets activated α4-integrin receptors in vivo. J Immunol 155:938-946, 1995
23. Hänninen A, Salmi M, Simell O, Jalkanen S: Mucosa-associated (β7-integrin high) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior. Diabetes 45:1173-1180, 1996
24. Ellis TM, Atkinson MA: The clinical significance of an autoimmune response against glutamic acid decarboxylase. Nature Med 2:148-153, 1996
25. Imhof BA, Dunon D: Leucocyte migration and adhesion. Adv Immunol 58:345-416, 1995
26. Dolimena M, Folli F, Denis-Donini S, Comi GC, Pozza G, De Camilli P, Vicari AM: Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy and type I diabetes mellitus. N Engl J Med 318:1012-1020, 1988
27. Wagner R, McNally JM, Bonifacio E, Genovese S, Foulis A, McGill M, Christie MR, Betterle C, Bosi E, Bottazzo GF: Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with β-selective GAD-speciflc islet cell antibodies. Diabetes 43:851-856, 1994
28. Hänninen A, Salmi M, Simell O, Jalkanen S: Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas: implications for pathogenesis of IDDM. Diabetes 42:1656-1662, 1993
29. Healey D, Ozegbe P, Arden S, Chandler P, Hutton J, Cooke A: In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest 95:2979-2985, 1995
30. Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ: Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 89:283-292, 1992
31. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94:2125-2129, 1994