Failure of heparin to inhibit the expression of the thrombin receptor following endothelial injury of the rabbit carotid artery

European Journal of Pharmacology

Volumn 327, Issue 2-3, 1997, Pages 157-162

  Guitteny, Anne Françoise ^a   Herbert, Jean Marc ^a  

^a SANOFI   (France)

Author keywords

Arterial injury; Heparin; In situ hybridization; Thrombin receptor

Indexed keywords

HEPARIN; THROMBIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM INJURY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031000409     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)89655-0     Document Type: Article

References (34)

1. Au Y.P.T., Kenagy R.D., Clowes A.W. Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis. J. Biol. Chem. 267:1992;3438-3444.
2. Barzu T., Herbert J.M., Desmouliere A., Carayon P., Pascal M. Characterization of rat aortic smooth muscle cells resistant to the heparin antiproliferative activity following long-term heparin treatment. J. Cell. Physiol. 160:1994;239-248.
3. Bloch B., Popovici T., Le Guellec D., Normand E., Chouham S., Guitteny A.F., Bohlen P. In situ hybridization histochemistry for the analysis of gene expression in the endocrine and central nervous system tissues: a 3-year experience. J. Neurosci. Res. 16:1986;183-200.
4. Brass L.F., Vassallo R.R. Jr., Belmonte E., Ahuja M., Cichowski K., Hoxie J.A. Structure and function of the human platelet thrombin receptor. J. Biol. Chem. 267:1992;13795-13798.
5. Cadroy Y., Gaspin D., Dupouy D., Lormeau J.C., Boneu B., Sié P. Heparin reverses the procoagulant properties of stimulated endothelial cells. Thromb. Haemost. 75:1995;190-195.
6. Chen L.B., Buchanan J.M. Mitogenic activity of blood components. I. Thrombin and prothrombin Proc. Natl. Acad. Sci. USA. 72:1975;131-135.
7. Chen L.B., Teng N.N.H., Buchanan J.M. Mitogenicity of thrombin and surface alterations on mouse splenocytes. Exp. Cell Res. 101:1976;41-46.
8. Clowes A.W., Clowes M.M. Kinetics of cellular proliferation after arterial injury. IV: Heparin inhibits rat smooth muscle mitogenesis and migration Circ. Res. 58:1986;839-845.
9. Clowes A.W., Clowes M.M., Kirkman T.R., Jackson C.L., Au Y.P.T., Kenagy R.D. Heparin inhibits the expression of tissue-type plasminogen activator in injured rat carotid artery. Circ. Res. 70:1992;1128-1136.
10. Eidt J.F., Allison P., Nobel S., Asthon J., Golino P., McNatt J., Buja L.M., Willerson J.T. Thrombin is an important mediator of platelet aggregation in stenosis canine coronary arteries with endothelial injury. J. Clin. Invest. 84:1989;18-27.
11. Fishman J.A., Ryan G.B., Karnovsky M.J. Endothelial regeneration in the rat carotid artery and the significance of endothelial denudation in the pathogenesis of myointimal thickening. Lab. Invest. 32:1975;339-347.
12. Geary R.L., Koyama K.K., Wang T., Vergel S., Clowes A.W. Failure of heparin to inhibit intimal hyperplasia in injured baboon arteries. Circulation. 91:1995;2972-2981.
13. Guitteny A.F., Fouque B., Mougin C., Teoule R., Bloch B. Histological detection of messenger RNAs with biotinylated synthetic oligonucleotide probes. J. Histochem. Cytochem. 36:1988;563-571.
14. Guyton J.R., Rosenberg R.D., Clowes A.W., Karnovsky M.J. Inhibition of rat arterial smooth muscle cell proliferation by heparin. I. In vivo studies with anticoagulant and non-anticoagulant heparin Circ. Res. 46:1980;625-634.
15. Harker L.A., Kelly A.B., Hanson S.R. Experimental arterial thrombosis in non-human primates. Circulation. 83:1991;IV41-IV55.
16. Herbert J.M., Lamarche I., Dol F. Induction of vascular smooth muscle cell growth by selective activation of thrombin receptor. Effect of heparin. FEBS Lett. 301:1992;155-158.
17. Herbert J.M., Tissinier A., Defreyn G., Maffrand J.P. Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits. Arterioscl. Thromb. 13:1993;1171-1179.
18. Herbert J.M., Dupuy E., Laplace M.C., Zini J.M., Bar Shavit R., Tobelem G. Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway. Biochem. J. 303:1994;227-231.
19. Herbert J.M., Guy A.F., Lamarche I., Mares A.M., Savi P., Dol F. Intimal hyperplasia following vascular injury is not inhibited by an antisense thrombin receptor oligodeoxynucleotide. J. Pharmacol. Exp. Ther. 170:1997;106-114.
20. Hoover R.L., Rosenberg R., Haering W., Karnovsky M.J. Inhibition of rat arterial smooth muscle cell proliferation by heparin: in vitro studies. Circ. Res. 47:1980;578-583.
21. Kenagy R.D., Clowes A.W. Regulation of baboon arterial smooth muscle cell plasminogen activators by heparin and growth factors. Thromb. Res. 77:1995;55-61.
22. Kenagy R.D., Nikkari S.T., Welgus H.G., Clowes A.W. Heparin inhibits the induction of three matrix metalloproteinases (stromelysis, 92-kD gellatinase and collagenase) in primate arterial smooth muscle cells. J. Clin. Invest. 93:1994;1987-1993.
23. McNamara C.A., Sarembock I.J., Gimple L.W., Fenton J.W. II, Coughlin S.R., Owens G.K. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J. Clin. Invest. 91:1993;94-98.
24. Nelken N.A., Soifer S.J., O'Keefe J., Vu T.K.H., Charo I.F., Coughlin S.R. Thrombin receptor expression in normal and atherosclerotic human arteries. J. Clin. Invest. 90:1992;1614-1621.
25. Ottlinger M.E., Pukak L.A., Karnovsky M.J. Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells. J. Biol. Chem. 268:1993;19173-19176.
26. 2+ mobilization. FEBS Lett. 288:1991;123-128.
27. Reilly C.F., Kindy M.S., Brown K.E., Rosenberg R.D., Sonenshein G.E. Heparin prevents vascular smooth muscle cell progression through the G1 phase of the cell cycle. J. Biol. Chem. 264:1989;6990-6995.
28. Sarembock I.J., Gertz S.D., Gimple L.W., Owen R.M., Powers E.R., Roberts W.C. Effectiveness of recombinant desulphatohirudin (CGP 39393) in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation. 84:1991;232-243.
29. Snow A.D., Bolender R.P., Wight T.N., Clowes A.W. Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells. Am. J. Pathol. 137:1990;313-330.
30. Vu T.K.H., Hung D.T., Wheaton V.I., Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 64:1991;1057-1068.
31. Weiss R.H., Maduri M. The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor. J. Biol. Chem. 268:1993;5724-5727.
32. Wilcox J.N., Rodriguez J., Subramanian R., Ollerenshaw J., Zhong C., Hayzer D.J., Horaist C., Hanson S.R., Lumsden A., Salam T.A., Kelly A.B., Harker L.A., Runge M. Characterization of thrombin receptor expression during vascular lesion formation. Circ. Res. 75:1994;1029-1038.
33. Wright T.C. Jr., Pukac L.A., Castellot J.J. Jr., Karnovsky M.J., Levine R.A., Kim-Park H.Y., Campisi J. Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway. Proc. Natl. Acad. Sci. USA. 86:1989;3199-3203.
34. Zhong C., Hayzer D.J., Corson M.A., Runge M.S. Molecular cloning of the rat vascular smooth muscle thrombin receptor. J. Biol. Chem. 267:1992;16975-16979.