Platelet factor 4, target of heparin-dependent antibodies. Application for the biological diagnostic of heparin induced thrombocytopenia;Le facteur 4 plaquettaire, cible des anticorps anti-heparine: Application au diagnostic biologique de la thrombopenie induite par l'eparine (TIH)

Annales de Medecine Interne

Volumn 148, Issue 2, 1997, Pages 142-149

  Amiral, Jean ^a,b  

^a Serbio ^*  (France)

^b PAE Parispace 3   (France)

Author keywords

antibodies; heparin; thrombocytopenia

Indexed keywords

ANTIBODY; HEPARIN; IMMUNOGLOBULIN G; LOW MOLECULAR WEIGHT HEPARIN; THROMBOCYTE FACTOR 4;

CONFERENCE PAPER; HUMAN; THROMBOCYTOPENIA;

ANTIBODIES; HEPARIN; HUMANS; PLATELET FACTOR 4; THROMBOCYTOPENIA;

EID: 0031000382     PISSN: 0003410X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (32)

1. HIRSH J. HEPARIN. N Engl J Med 1991 ; 234 : 1563-74.
2. LINDAHL U, LIDHOLT K, SPILLMANN D, KJELLÉN L. More to « heparin » than anticoagulant. Thromb Res 1994 ; 75 : 1-32.
3. BRANDT E, FLAD HD. Structure and function of platelet-derived cytokines of the β-thromboglobulin/interleukin 8 family. Platelets 1992 ; 3 : 295-305.
4. CHONG BH. Heparin-induced thrombocytopenia. BR J HAEMATOL 1995 ; 89 : 431-9.
5. AMIRAL J, MEYER D. Rôle du facteur plaquettaire 4 (PF4) dans les thrombopénies induites par l'héparine. STV 1995 ; 7 : 549-55.
6. AMIRAL J, BRIDEY F, DREYFUS M, et al : Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin induced thrombocytopenia. Thromb Haemost 1992 ; 68 : 95-6.
7. AMIRAL J, BRIDEY F, WOLF M, et al : Antibodies to macromolecular platelet factor 4-heparin complexes in heparin induced thrombocytopenia : a study of 44 cases. Thromb Haemost 1995 ; 73 : 21-8.
8. AMIRAL J, PEYNAUD-DEBAYLE E, WOLF M, BRIDEY F, VISSAC AM, MEYER D. Generation of antibodies to Heparin-PF4 complexes without thrombocytopenia in patients treated with unfractionated or low molecular weight heparin. Am J Hematol 1996 ; 52 : 90-5.
9. AMIRAL J, WOLF M, VISSAC AM, MEYER D. Mécanismes moléculaires et cellulaires des thrombopénies induites par l'héparine. Hématologie 1996 ; 2 : 1-8.
10. AMIRAL J, MARFAING-KOKA A, WOLF M, et al : D. Presence of auto-antibodies to interleukin-8 or neutrophil activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood 1996, 88: 410-416.
11. KELTON JG, SMITH JW, WARKENTIN TE, HAYWARD CPM, DENOMME GA, HORSEWOOD P. Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4. BLOOD 1994 ; 83 : 3232-9.
12. AMIRAL J, WOLF M, FISCHER AM, BOYER-NEUMANN C, VISSAC AM, MEYER D. Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin induced thrombocytopenia. Br J Haematol 1996 ; 92 : 954-9.
13. VISENTIN GP, FORD SE, SCOTT JP, ASTER RH. Antibodies from patients with heparin-induced thrombocytopenia/ thrombosis are specific for platelet factor 4 complexes with heparin or bound to endothelial cells. J Clin Invest 1994 ; 93 : 81-8.
14. WARKENTIN TE, LEVINE MN, HIRSH J, et al : Heparin-induced thrombocytopenia in patients treated with low molecular-weight heparin or unfractionated heparin. N Engl J Med 1995 ; 332 : 1330-5.
15. HACH-WUNDERLE V, KAINER K, KRUG B, MÜLLER-BERGHAUS G, PÖTZSCH B. Heparin-associated thrombosis despite normal platelet counts. Lancet 1994 ; 344 : 469-70.
16. O'BRIEN JR, ETHERINGTON MD, PASHLEY M. Intra-platelet platelet factor 4 (IP.PF4) and the heparin-mobilisable pool of PF4 in health and atherosclerosis. Thromb Haemost 1984 ; 51 : 354-7.
17. HORNE III McDK, CHAO ES. Heparin binding to resting and activated platelets. Blood 1989 ; 74 : 238-43.
18. GREINACHER A, PÖTZCH B, AMIRAL J, DUMMEL V, EICHNER A, MUELLER-ECKHARDT C. Heparin associated thrombocytopenia : isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen. Thromb Haemost 1994 ; 71 : 247-51.
19. RUBINSTEIN E, BOUCHEIX C, WORTHINGTON RE, CAROLL RC. Anti-platelet antibody interactions with Fcγ receptor. Semin Thromb Hemost 1995 ; 21 : 10-22.
20. NASH GB. Adhesion between neutrophils and platelets : a modulator of thrombotic and inflammatory events ? Thromb Res 1994 ; 74 : S3-S11.
21. MARCUS AJ, SAFIER LB, BROEKMAN MJ, et al : Thrombosis and inflammation as multicellular processes : significance of cell-cell interactions. Thromb Haemost 1995 ; 74 : 213-7.
22. SHEN L. Receptors for IgA on phagocytic cells. Immunol Res 1992 ; 11 : 273-82.
23. FOLLEA G, HAMANDJIAN I, TRZECIAK MC, NEDEY C, STREICHENBERGER R, DECHAVANNE M. Pentosane polysulphate associated thrombocytopenia. Thromb Res 1986 ; 42 : 413-418.
24. CHONG BH, PILGRIM RL, COOLEY MA, CHESTERMAN CN. Increased expression of platelet IgG Fc receptors in immune heparin induced thrombocytopenia. Blood 1993 ; 81 : 988-93.
25. BRANDT J, ISENHGART CE, OSBORNE JM, AHMED A, ANDERSON CL. On the role of platelet FcγRIIA phenotype in heparin-induced thrombocytopenia. Thromb Haemost 1995 ; 74 : 1564-72.
26. HUISSE MC, GUILLIN MC, BEZEAUD Z, TOULEMONDE F, KITZIS M, ANDREASSIAN B. Heparin-associated thrombocytopenia. In vitro effects of different molecular weight heparin fractions. Thromb Res 1982 ; 27 : 485-90.
27. SHERIDAN D, CARTER C, KELTON J.G. A diagnostic test for heparin-induced thrombocytopenia. Blood 1986 ; 67 : 27-30.
28. GREINACHER A, MICHELS I, KIEFEL V, MUELLER-ECKHARDT C. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb Haemost 1991 ; 66 : 734-6.
29. STEWART MW, ETCHES WS, BOSHKOV LK, GORDON PA. Heparin-induced thrombocytopenia : an improved method of detection based on lumi-aggregometry. Br J Haematol 1995 ; 91 : 173-7.
30. GREINACHER A, AMIRAL J, DUMMEL V, VISSAC AM, KIEFEL V, MUELLER-ECKHARDT C. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin induced platelet activation test, and platelet factor 4/heparin enzyme linked immunosorbant assay. Transfusion 1994 ; 34 : 381-5.
31. AREPALLY G, REYNOLDS C, TOMASKI A, et al : Comparison of PF4/heparin ELISA assay with 14C-serotonin release assay in the diagnosis of heparin induced thrombocytopenia. Am J Clin Pathol 1995 ; 104 : 648-54.
32. BENDTZEN K, HANSEN MB, ROSS C, POULSEN LK, SVENSON M. Cytokines and autoantibodies to cytokines. Cells 1995 ; 13 : 206.