Biological matrix-dependent pharmacokinetic and pharmacodynamic parameters of a novel platelet glycoprotein IIB/IIIA receptor antagonist, XU063, in beagle dogs

Thrombosis Research

Volumn 86, Issue 3, 1997, Pages 221-232

  Kapil, Ram P ^a   Emm, Thomas A ^b   Mousa, Shaker A ^b   Padovani, Patricia K ^b   Quon, Check Y ^b   Lam, Gilbert N ^b  

^a DUPONT COMPANY   (United States)

^b NONE

Author keywords

Antiplatelet agent; Biological matrix; GP IIb IIIa receptor antagonist; Pharmacodynamics; Pharmacokinetids; Platelet poor plasma; Platelet rich plasma; XU063

Indexed keywords

3 N [2 [3 (4 FORMAMIDINOPHENYL)ISOXAZOLIN 5 YL]ACETYL] 2 N (1 BUTOXYCARBONYL) 2,3 DIAMINOPROPIONIC ACID; ANTITHROMBOCYTIC AGENT; FIBRINOGEN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; XU 063;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DOG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD PROTEINS; BLOOD SPECIMEN COLLECTION; DOGS; HALF-LIFE; ISOXAZOLES; MALE; METABOLIC CLEARANCE RATE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING;

EID: 0030999658     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(97)00065-0     Document Type: Article

References (21)

1. WITYAK, J., PINTO, D.J., WANG, S., SZE, J.Y., MOUSA, S.A., OLSON, R.E. and WEXLER, R. ACS Natl. Mtg., 211, Abstract No. 131, 1996.
2. XUE, C.B., WITYAK, J., SIELECKI, T.M., CAIN, G.A., LIU, J., BOSTROM, L.L., DIMEO, S.V., HIGLEY, C.A., LALKA, G.K., TOBIN, A.E., FRIETZE, W.E., EMMETT, G., MOUSA, S.A., SZE, J.Y., THOOLEN, M.J., REILLY, T.M., DEGRADO, W.F., OLSON, R.E. and WEXLER, R. ACS Natl. Mtg., 211 Abstract No. 132, 1996.
3. OLSON, R.E., WITYAK, J., XUE, C.B., SIELECKI, T.M., CAIN, G.A., MOUSA, S.A., THOOLEN, M.J., RACANELLI, A.L., HAUSNER, E.A., REILLY, T.M., DEGRADO, W.F. and WEXLER, R. ACS Natl. Mtg., 211 Abstract No. 250, 1996.
4. MOUSA, S.A., BOZARTH, J., FORSYTHE, M., XUE, C.B., WITYAK, J., OLSON, R.E., THOOLEN and M.J., REILLY, T.M. Recep. Bind. & Specif. Circul., 94 (8), 1-513, 3006 1996.
5. MOUSA, S.A. The DuPont Merck Pharmaceutical Company, Pharmaceutical Research Report No. PRR95-19, 1995.
6. LAPOSATA, M. , CONNOR, A.M., HICKS, D.G. and PHILLIPS, D.K. In: The Clinical Hemostasis Handbook, pp 175, Year Book Medical Publishers, Inc., Chicago-London-Boca Raton-Littleton, Mass., 1989.
7. SHATTIL, S.J. and BRASS L.F. Nouv. Rev. Fr. Hematol., 27, 211-217, 1985.
8. MOUSA, S.A., FORSYTHE, F. LORELLI, W., BOZARTH, J., XUE, C.B., WITYAK, J., SIELECKI, T.M., OLSON, R.E., DEGRADO, W., KAPIL, R.P., HUSSAIN, M., WEXLER, R., THOOLEN, M.J. and REILLY, T.M. Coronary Artery Disease, 7(10), 767-774, 1996.
9. BARRETT, J.S., GOULD, R.J., ELLIS, J.D., HOLAHAN, M.M., STRANIERI, M.T., LYNCH, JR., J.J., HARTMAN, G.D., IHLE, N., DUGGAN, M., MORENO, O.A. and THEOHARIDES, A.D. Pharmaceutical Research, 11(3), 426-431, 1994.
10. NICHOLSON, N.S., PANZER-KNODLE, S., SALYERS, A.K., TAITE, B.B., SZALONY, J.A., HAAS, N.F., KING, L.W., ZABLOCKI, J.A., KELLER, B.T., BROSCHAT, K., ENGLEMAN, V.W., HERIN, M., JACQMIN, P. and FEIGEN, L.P. Circulation, 91, 403-410, 1995.
11. SZALONY, J.A., HAAS, N.F., SALYERS, A.K., TAITE, B.B., NICHOLSON, N.S., MEHROTRA, D.V. and FEIGEN, L.P. Circulation, 91, 411-416, 1995.
12. KLEIMAN, N.S., RAIZNER, A.E., JORDAN, R., WANG, A.L., NORTON, D., MACE, K.F., JOSHI, A., COLLER, B.S. and WEISMAN, H.F. J. Am. Coll.Cardiol., 26, 1665-1671, 1995.
13. KAWAMURA, M., IMURA, Y., MORIYA, N., KITA, S., FUKUSHI, H., SUGIHARA, H., NISHIKAWA, KOHEI AND TERASHITA, Z.I. J. Phar. Exp. Ther., 277(1), 502-510, 1996.
14. SALYERS, A.K., SZALONY, J.A., TAITE, B.B., HAAS, N.F., MEHROTRA, D.V., FEIGEN, L.P. and NICHOLSON, N.S. Thromb. Res., 75(4), 409-417, 1994.
15. MOUSA, S.A., DEGRADO, W.F., MU, D.X., KAPIL, R.P., LUCCHESI, B.R. and REILLY, T.M. Circulation, 93, 537-543, 1996.
16. IMURA, Y., STASSEN, J.M., BUNTING, S., STOCKMANS, F. and COLLEN, D. Blood, 80(5), 1247-1253, 1992.
17. PEERLINCK, K., LEPELEIRE, D., GOLDBERG, M., FARELL, D., BARETT, J.S., HAND, E., PANEBIANCO, D., DECKMYN, H., VERMYLEN, J. AND ARNOUT, J. Circulation, 88(1), 1512-1517, 1993.
18. BARRETT, J.S., MURPHY, G., PEERLINCK, K., LEPELEIRE, I.D., GOULD, R.J., PANEBIANCO, D., HAND, E., DECKMYN, H., VERMYLEN, J. and ARNOUT, J. Clin. Pharmacol. Ther., 55, 377-388, 1994.
19. NICHOLS, A.J., VASKO, J.A., KOSTER, P.F., VALCIK, R.E., RHODES, G.R., MILLER-STEIN, C., BOPPANA, V. and SAMANEN, J.M. J. Exp. Phar. Ther., 270(2), 614-621, 1994.
20. KAPIL, R. Internal Report of The DuPont Merck Pharmaceutical Company, Drug Metabolism and Pharmacokinetics Section, Report No. DM&P 95-082, 1995.
21. WYLD, P.J. Platelet Function Tests, In: Clinical Measurement in Drug Evaluation. W.Nimmo and Geoffrey Tucker (eds.) pp 127-128, John Wiley & Sons, Chichester, New York, Brisbane, Toronto, London, 1995.