Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro

Journal of Neuroscience Research

Volumn 48, Issue 6, 1997, Pages 499-506

  Dorandeu, F ^a   Wetherell, J ^b   Pernot Marino, I ^a   Tattersall, J E H ^b   Fosbraey, P ^b   Lallement, G ^a  

^a CENTRE DE RECHERCHES   (France)

^b Medical Countermeasures   (United Kingdom)

Author keywords

Dendrotoxin; Glu receptor antagonists; Rat hippocampus

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOPYRIDINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; 6,7 DINITRO 2,3 QUINOXALINEDIONE; ACETYLCHOLINE; AMINO ACID RECEPTOR BLOCKING AGENT; ASPARTIC ACID; DENDROTOXIN; DIZOCILPINE; EXCITATORY AMINO ACID RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; EPILEPTIC DISCHARGE; HIPPOCAMPUS; MALE; NERVE CELL LESION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ACETYLCHOLINE; ACTION POTENTIALS; ANIMALS; ASPARTIC ACID; DIZOCILPINE MALEATE; ELAPID VENOMS; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HIPPOCAMPUS; MALE; NEUROTOXINS; NEUROTRANSMITTER AGENTS; POTASSIUM CHANNELS; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES;

EID: 0030999609     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19970615)48:6<499::AID-JNR2>3.0.CO;2-5     Document Type: Article

References (27)

1. Alger BE (1984): Hippocampus: Electrophysiological studies of epileptiform activity in vitro. In Dingledine R (ed): "Brain Slices." New York: Plenum Press, pp 155-199.
2. + channel sub-types in rat brain: characteristic locations revealed using β-bungarotoxin, α- and δ-dendrotoxins. Neuroscience 40:29-39.
3. + channel blocker. Neurosci Lett 139:34-40.
4. + channel blocker - involves non-NMDA receptor activation. Neurochem Int 24:81-90.
5. Bagetta G, Iannone M, Palma E, Nistico G, Dolly JO (1996): N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors mediate seizures and CA1 hippocampal damage induced by dendrotoxin-K in rats. Neuroscience 71:613-624.
6. 2+-dependent releasable pool of glutamate in striatal synaptosomes associated with dendrotoxin-induced potassium channel blockade. J Neural Transm 80:167-179.
7. Coleman MH, Yamaguchi S, Rogawski MA (1992): Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs. Brain Res 575:138-142.
8. Docherty RJ, Dolly JO, Halliwell JV, Othman I (1983): Excitatory ettects of dendrotoxin on the hippocampus in vitro. J Physiol (London) 336:58-59.
9. 3H)noradrenaline release from rat cerebral cortex. Eur J Pharmacol 248:85-88.
10. + channel blocker-induced seizures. Brain Res 495:189-192.
11. + channel inhibitors. Eur J Pharmacol 160:173-177.
12. Halliwell JV, Othman IB, Pelchen-Matthews A, Dolly JO (1986): Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors. Proc Natl Acad Sci USA 83:493-497.
13. Harvey AL, Anderson AJ (1991): Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. In Harvey AL (ed): "International Encyclopedia of Pharmacology and Therapeutics, Snake Toxins." New York: Pergamon Press, Inc., pp 131-160.
14. 3H)noradrenaline release from rat hippocampus. Eur J Pharmacol 209:87-93.
15. Lallement G, Fosbraey P, Baille-Le-Crom V, Tattersall JEH, Blanchet G, Wetherell JR, Rice P, Passingham SL, Sentenac-Roumanou H (1995): Compared toxicity of the potassium channel blockers, apamin and dendrotoxin. Toxicology 104:47-52.
16. Lowry OH, Rosebrough NF, Farr AL, Randall RJ (1951): Protein measurements with the Folin phenol reagent. J Biol Chem 193:265-275.
17. Lindroth P, Mopper K (1979): High performance liquid Chromatographic determination of sub picomole amounts of amino acids by precolumn fluorescence derivatisation with O-phtaldialdehyde. Anal Chem 51:1667-1674.
18. Morales-Villagrán A, Ureña-Guerrero ME, Tapia R (1996): Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. Eur J Pharmacol 305:87-93.
19. + current of rat hippocampal neurones in vitro. J Physiol (London) 457:575-590.
20. + channel probe. Neuroscience 29:347-361.
21. Perreault P, Avoli M (1991): Physiology and pharmacology of epileptiform activity induced by 4-Aminopyridine in rat hippocampal slices. J Neurophysiol 65:771-785.
22. Sequier JM, Brennand J, Barhanin J, Lazdunski M (1990): Regional expression of a MCD-peptide and dendrotoxin I-sensitive voltage-dependent potassium channel in rat brain. FEBS Lett 263:163-165.
23. 2+ and glutamate release. J Neurochem 53:1693-1699.
24. 2+-dependent release of glutamate from guinea-pig cerebrocortical synaptosomes. J Neurochem 52:201-206.
25. + channel mRNAs in the rat brain and down-regulation in the hippocampus following seizures. Neuron 8:1055-1067.
26. Weller U, Bernhardt U, Siemen D, Dreyer F, Vogel W, Habermann E (1985): Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin. Naunyn Schmiedebergs Arch Pharmacol 330:77-83.
27. Yamaguchi S, Rogawski MA (1991): Effect of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice. Epilepsia 32(Suppl 3):5.