Effects of the calcium ionophore A23187 on airway responsiveness to histamine and substance P in guinea pigs

Inflammation Research

Volumn 46, Issue 3, 1997, Pages 108-113

  Uno, D ^a   Tsukagoshi, H ^a   Hisada, T ^a   Iwamae, S ^a   Mori, M ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

A23187; Histamine; Neutral endopeptidase; Nitric oxide; Substance P

Indexed keywords

CALCIMYCIN; CALCIUM IONOPHORE; EVANS BLUE; HISTAMINE; MEMBRANE METALLOENDOPEPTIDASE; NITRIC OXIDE; NITRITE; SUBSTANCE P;

AIRWAY CONDUCTANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EPITHELIUM CELL; GUINEA PIG; INFLAMMATORY CELL; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; LUNG LAVAGE; MALE; NEUTROPHIL; NONHUMAN; RESPIRATORY EPITHELIUM;

ANIMALS; BRONCHI; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CALCIMYCIN; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; HISTAMINE; IONOPHORES; MALE; MICROCIRCULATION; SUBSTANCE P; TRACHEA;

EID: 0030999204     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050125     Document Type: Article

References (25)

1. Stengel PW, Williams GD, Silbaugh SA. A23187-induced pulmonary gas trapping and inflammation in the guinea pig. Agents Actions 1991;32:270-6.
2. Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity. Am Rev Respir Dis 1980;121:289-413.
3. Lundberg JM, Saria A, Brodin E, Rosell S, Folkers K. A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig. Proc Natl Acad Sci USA 1993;80:1120-4.
4. Ollerenshaw SL, Jarvis DL, Woolcock AJ, Scheibner T, Sullivan CE. Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. Eur Respir J 1991;4:673-82.
5. Skidgel RA, Engelbrecht A, Johnson AR, Erdos EG. Hydrolysis of substance P and neurokinins by converting enzyme and neutral endopeptidase. Peptides 1984;5:769-76.
6. Sheppard D, Thompson JE, Scypinski L, Dusser DJ, Nadel JA, Borson DB. Toluene diisocyanate increases airway responsiveness to substance P and decreases airway neutral endopeptidase. J Clin Invest 1988;81:1111-5.
7. Dusser DJ, Djokic TD, Borson DB, Nadel JA. Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig: possible role of free radicals. J Clin Invest 1989;84:900-6.
8. Dusser DJ, Jacoby DB, Djokic TD, Rubinstein I, Borson DB, Nadel JA. Virus induces airway hyperresponsiveness to tachykinins: role of neutral endopeptidase. J Appl Physiol 1989;67:1504-11.
9. Stengel PW, Bendele AM, Cockerham SE, Silbaugh SA. Inhaled A23187 produces a preferential sensitization to substance P. Am Rev Respir Dis 1993;147:196-201.
10. Bult H, Boeckxstaens GE, Pelckkmans PA, Jordaens FH, VanMaercke YM, Herman AG. Nitric oxide as an inhibitory non-adrenergic non-cholineric neurotransmitter. Nature 1990;345:346-7.
11. Belvisi MG, Stretton CD, Yacoub M, Barnes PJ. Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur J Pharmacol 1992;210:221-2.
12. Blough NV, Zafiriou OC. Reaction of superoxide with nitric oxide to form peroxinitrite in alkaline aqueous solution. Inorg Chem 1985;24:3502-4.
13. Gryglewski RJ, Palmer RMJ, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986;320:454-6.
14. Murray JJ, Fridovich I, Makhoul RG, Hagen PO. Stabilization and partial characterization of endothelium derived relaxing factor from cultured bovine aortic endothelial cells. Biochem Biophys Res Commun 1986;141:689-96.
15. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-6.
16. Florentin D, Sassi A, Roques BP. A highly sensitive fluorometric assay for "enkephalinase", a neutral metalloendopeptidase that releases tyrosine-glycine-glycine from enkephalins. Anal Biochem 1984;141:62-9.
17. Lowry OH, Rosebrough NJ, Farr, AH, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-75.
18. Schmidt HHHW, Nau H, Wittfoht W, Gerlach J, Prescher K-E, Klein MM, et al. Arginine is a physiological precursor of endothelium-derived nitric oxide. Eur J Pharmacol 1988;154:213-6.
19. Lei Y-H, Barnes PJ, Rogers DF. Regulation of NANC neural bronchoconstriction in vivo in the guinea-pig: involvement of nitric oxide, vasoactive intestinal peptide and soluble guanylyl cyclase. Br J Pharmacol 1993;108:228-35.
20. Stuart-Smith K, Vanhoutte PM. Heterogeneity in the effects of epithelium removal in the canine bronchial tree. J Appl Physiol 1987;63:2510-5.
21. Nijkamp FP, van der Linde HJ, Folkerts G. Nitric oxide synthesis inhibition induces airway hyperresponsiveness: role of the epithelium [abstract]. Am Rev Respir Dis 1993;147:287a.
22. Shore SA, Romero L. Effect of a nitric oxide synthase inhibitor on bronchoconstriction induced by intravenous histamine [abstract]. Am Rev Respir Dis 1993;147:445a.
23. Stork AP, Cocks TM. Pharmacological reactivity of human epicardial coronary arteries: characterization of relaxation responses to endothelium-derived relaxing factor. Br J Pharmacol 1994;113:1099-104.
24. Jordan ML, Rominski B, Jaquins-Gerstl A, Celler D, Hoffman RA. Regulation of inducible nitric oxide production by intracellular calcium. Surgery 1995;118:138-46.
25. 2, and HOCl. Arch Biochem Biophys 1993;301:189-96.