Heparin-binding, highly basic regions within the thyroglobulin type-1 repeat of insulin-like growth factor (IGF)-binding proteins (IGFBPs) -3, -5, and -6 inhibit IGFBP-4 degradation

Endocrinology

Volumn 138, Issue 6, 1997, Pages 2280-2285

  Fowlkes, John L ^a   Thrailkill, Kathryn M ^a   George Nascimento, Carlos ^b   Rosenberg, Carlyn K ^c   Serra, Delila M ^c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Bios Chile IGSA   (Chile)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; THYROGLOBULIN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

EID: 0030998472     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.6.5182     Document Type: Article

References (27)

1. Rechler MM 1993 Insulin-like growth factor binding proteins. Vitam Horm 47:1-114
2. Bach LA, Rechler MM 1995 Insulin-like growth factor binding proteins. Diabetes Rev 3:38-61
3. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
4. Rechler MM 1995 Non-receptor-binding proteins for insulin-like growth factors and other cytokines: modulators of peptide action. In: Weintraub BD (ed) Molecular Endocrinology: Basic Concepts and Clinical Correlations. Raven Press, New York, pp 155-180
5. Fowlkes J, Freemark M 1992 Evidence for a novel insulin-like growth factor (IGF)-dependent protease regulating IGF-binding protein-4 in dermal fibroblasts. Endocrinology 131:2071-2076
6. Conover CA, Kiefer MC, Zapf J 1993 Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies. J Clin Invest 91:1129-1137
7. Myers SE, Cheung PT, Handwerger S, Chernausek SD 1993 Insulin-like growth factor-I (ICF-I) enhanced proteolysis of IGF-binding protein-4 in conditioned medium from primary cultures of human decidua: independence from IGF receptor binding. Endocrinology 133:1525-1531
8. Kamyar A, Pirola CJ, Wang HM, Sharifi B, Mohan S, Forrester JS, Fagin JA 1994 Expression and insulin-like growth factor-dependent proteolysis of insulin-like growth factor-binding protein-4 are regulated by cell confluence in vascular smooth muscle cells. Circ Res 74:576-585
9. Durham SK, Kiefer MC, Riggs BL, Conover CA 1994 Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology. J Bone Miner Res 9:111-117
10. Conover CA, Clarkson JT, Bale LK 1993 Phorbol ester tumor promoters regulate insulin-like growth factor-binding protein-4 proteolysis. Endocrinology 133:1347-1351
11. Fowlkes JL, Serra DM, Rosenberg CK, Thrailkill KM 1995 Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) functions as an IGF-reversible inhibitor of IGFBP-4 proteolysis. J Biol Chem 270:27481-27488
12. Fowlkes JL, Serra DM 1996 Characterization of glycosaminoglycan-binding domains present in insulin-like growth factor-binding protein-3. J Biol Chem 271:14676-14679
13. Kiefer MC, Schmid C, Waldvogel M, Schläpfer I, Futo E, Masiarz FR, Green K, Barr PJ, Zapf J 1992 Characterization of recombinant human insulin-like growth factor binding proteins 4, 5 and 6 produced in yeast. J Biol Chem 267:12692-12699
14. Sommer A, Maack CA, Spratt SK, Mascarenhas D, Tressel TJ, Rhodes ET, Lee R, Roumas M, Tatsuro GP, Flynn JA, Gerber N, Taylor J, Cudney H, Nanney L, Hunt TK, Spencer EM 1991 Molecular genetics and actions of recombinant insulin-like growth factor binding protein-3. In: Spencer EM (ed) Modern Concepts of Insulin-Like Growth Factors. Elsevier, New York, pp 715-728
15. Thrailkill KM, Quarles LD, Nagase H, Suzuki K, Serra DM, Fowlkes JL 1995 Characterization of insulin-like growth factor-binding protein-5-degrading proteases produced throughout murine osteoblast differentiation. Endocrinology 136:3527-3533
16. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head bacteriophage T. Nature 227:680-685
17. Conover CA, Durham SK, Zapf Z, Masiarz FR, Kiefer MC 1995 Cleavage analysis of insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis and expression of protease-resistant IGF-binding protein-4 mutants. J Biol Chem 270:4395-4400
18. Fowlkes JL, Enghild JJ, Suzuki K, Nagase H 1994 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. J Biol Chem 269:25742-25746
19. Campbell PG, Novak JF, Yanosick TB, McMaster JH 1992 Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex. Endocrinology 130:1401-1412
20. Cohen P, Graves CBG, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG 1992 Prostate specific antigen is an IGF binding protein-3 (IGFBP-3) protease found in seminal plasma. J Clin Endocrinol Metab 75:1046-1053
21. Molina F, Pau B, Granier C 1996 The type-1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes. FEBS Lett 391:229-231
22. Yamashita M, Konagaya S 1996 A novel cysteine protease inhibitor of the egg of chum salmon, containing a cysteine-rich thyroglobulin-like motif. J Biol Chem 271:1282-1284
23. Bar RS, Boes M, Booth BA, Dake BL, Moser DR, Erondu NE 1994 Vascular endothelium, IGFs, and IGF binding proteins. In: Baxter RC, Gluckman PD, Rosenfeld RG (eds) The Insulin-like Growth Factors and Their Regulatory Proteins. Excerpta Medica, Amsterdam, pp 237-244
24. Booth BA, Boes M, Andress DL, Dake BL, Kiefer MC, Maack C, Linhardt RJ, Bar K, Caldwell EE, Weiler J, Bar RS 1995 IGFBP-3 and 1GFBP-5 associate with endothelial cells: role of C-terminal heparin binding domain. Growth Regul 2:1-17
25. Andress DL 1995 Heparin modulates the binding of insulin-like growth factor (IGF) binding protein-5 to a membrane protein in osteoblast cells. J Biol Chem 270:28289-28296
26. Arai T, Parker AJ, Busby Jr WH, Clemmons DR 1994 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes. J Biol Chem 269:20388-20393
27. Parker A, Clarke JB, Busby Jr WH, Clemmons DR 1996 Identification of the extracellular matrix binding sites for insulin-like growth factor-binding protein-5. J Biol Chem 271:13523-13529