Kinetics of splenocyte interleukin-4 production after injury and lethal endotoxin challenge

Journal of Surgical Research

Volumn 67, Issue 1, 1997, Pages 33-39

  Napolitano, Lena M ^a   Campbell, Cara ^b   Bass, Barbara L ^a  

^a UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; ENDOTOXIN; INTERLEUKIN 10; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; RECOMBINANT INTERLEUKIN 10; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDOTOXEMIA; FEMUR FRACTURE; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LETHALITY; MALE; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE ACTIVATION;

EID: 0030998146     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.4925     Document Type: Article

References (24)

1. 1. Hoch, R. C., Rodriguez, R., Manning, T., et al. Effects of accidental trauma on cytokine and endotoxin production. Crit. Care Med. 21: 839, 1993.
2. 2. Faist, E., Ertel, W., Mewes, A., et al. Trauma-induced alterations of the lymphokine cascade. In E. Faist, J. Ninnemann, and D. Greed (Eds.), Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches. Berlin: Springer-Verlag, 1989. Pp. 79-84.
3. 3. Fearon, D. R., and Locksley, R. M. The instructive role of innate immunity in the acquired immune response. Science 272: 50-54, 1996.
4. 4. Fiorentino, D. F., Bond, M. W., and Mosmann, T. R. Two types of mouse T helper cells. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170: 2081-2095, 1989.
5. 5. Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., and O'Garra, A. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815-3822, 1991.
6. 6. deWaal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. F., and deVries, J. E. Interleukin 10 inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174: 1209-1220, 1991.
7. 7. Fiorentino, D. F., Zlotnik, A., Vierira, P., Mosmann, T. R., Howard, M., Moore, K. W., and O'Garra, A. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146: 3444-3451, 1991.
8. 8. Napolitano, L. M., and Campbell, C. Nitric oxide inhibition normalizes splenocyte interleukin-10 synthesis in murine thermal injury. Arch. Surg. 129: 1276-1283, 1994.
9. 9. Napolitano, L. M., and Campbell, C. Polymicrobial sepsis following trauma inhibits interleukin-10 secretion and lymphocyte proliferation. J. Trauma 39(1): 104-111, 1995.
10. 10. Howard, M., Muchamuel, T., Andrade, S., and Menon, S. Interleukin-10 protects mice from lethal endotoxemia. J. Exp. Med. 177: 1205-1208, 1993.
11. 11. Gerard, C., Bruyns, C., Marchant, A., Abramowicz, D., Vandenabeele, P., Delvaux, A., Fiers, W., Goldman, M., and Velu, T. Interleukin-10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 177: 547-550, 1993.
12. 12. Napolitano, L. M., and Campbell, C. Interleukin-10 decreases mortality in a lethal murine trauma/sepsis model. Abstract presented at the Surgical Infection Society Fifteenth Annual Meeting, April 20-22, 1995.
13. 13. Swain, S. L., Weinberg, A. D., English, M., and Huston, G. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145: 3796-3806, 1990.
14. 14. Rhoades, K. L., Cai, S., Golub, S. H., and Economou, J. S. Granulocyte-macrophage colony-stimulating factor and interleukin-4 differentially regulate the human tumor necrosis factor-alpha promoter region. Cell Immunol. 161(1): 125-131, 1995.
15. 15. Coyle, A. J., LeGros, G., Bertrand, C., Tsuyuki, S., Heusser, C. H., Kopf, M., and Anderson, G. P. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Respir. Cell Mol. Biol. 13(1): 54-59, 1995.
16. 16. Kopf, M., LeGros, G., Bachmann, M., Lamers, M. C., Bluethmann, H., and Kohler, G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362: 245-248, 1993.
17. 17. Ayala, A., Lehman, D. L., Herdon, C. D., and Chaudry, I. H. Mechanism of enhanced susceptibility to sepsis following hemorrhage. Interleukin-10 suppression of T-cell response is mediated by eicosanoid-induced interleukin-4 release. Arch. Surg. 129: 1172-1178, 1994.
18. 18. Houssiau, F. A., Schandene, L., Stevens, M., Cambiaso, C., Goldman, M., vanSnick, J., Renauld, J. C. A cascade of cytokines is responsible for IL-9 expression in human T cells. Involvement of IL-2, IL-4 and IL-10. J. Immunol. 154(6): 2624-2630, 1995.
19. 19. Molloy, R. G., O'Riordain, M., Holzheimer, R., et al. Mechanism of increased tumor necrosis factor production after thermal injury: Altered sensitivity to PGE2 and immunomodulation with indomethacin. J. Immunol. 151: 2142-2149, 1993.
20. 20. O'Riordain, D. S., Mendez, M. V., O'Riordain, M. G., et al. Molecular mechanisms of decreased interleukin-2 production after thermal injury. Surgery 114: 407-415, 1993.
21. 21. Wood, J. J., Rodrick, M. L., O'Mahoney, M. L., et al. Inadequate interleukin-2 production: A fundamental immunological deficiency in patients with major burns. Ann. Surg. 200: 311-320, 1984.
22. 22. Teodorczk-Injuyan, J. A., Sparkes, B. G., Mills, B. G., Falk, R. E., and Peters, W. R. Impaired expression of interleukin-2 receptor in the immunosuppressed burn patient: Reversal by exogenous IL-2. J. Trauma 27: 180, 1987.
23. 23. Sieling, P. A., Abrams, J. S., Yamamura, M., Salgame, P., Bloom, B. R., Rea, T. H., and Modline, R. L. Immunosuppressive roles for IL-10 and IL-4 in human infection. J. Immunol. 150: 5501-5510, 1993.
24. 24. Schwarz, M., Majdic, O., Knapp, W., and Holter, W. High-level IL-10 production by monoclonal antibody-stimulated human T cells. Immunology 86(3): 364-371, 1995.