Mild endotoxaemia and the inflammatory response induced by a marathon race

Clinical Science

Volumn 92, Issue 4, 1997, Pages 415-422

  Camus, G ^a   Poortmans, J ^b   Nys, M ^a   Deby Dupont, G ^a   Duchateau, J ^b   Deby, C ^a   Lamy, M ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b BRUGMANN UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Complement; Endotoxin; Exercise; Inflammatory response; Myeloperoxidase

Indexed keywords

ANAPHYLATOXIN; BACTERIUM LIPOPOLYSACCHARIDE; COMPLEMENT COMPONENT C5A; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 6; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN EXPERIMENT; HUMORAL IMMUNITY; INFLAMMATION; MALE; MARATHON RUNNER; NORMAL HUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 0030998071     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0920415     Document Type: Article

References (43)

1. Camus G, Deby-Dupont G, Deby C, Juchmès-Ferir A, Pincemail J, Lamy M. Inflammatory response to strenuous muscular exercise in man. Mediators of Inflammation 1993; 2: 335-42.
2. McCarthy DA, Dale MM. The leucocytosis of exercise. A review and a model. Sports Med 1988; 6: 333-63.
3. Dufaux B, Order U. Plasma elastase-α 1-antitrypsin, neopterin, tumor necrosis factor, and soluble interleukin-2 receptor after prolonged exercise. Int J Sports Med 1989; 10: 434-38.
4. Camus G, Deby-Dupont G, Duchateau J, Deby C, Pincemail J, Lamy M. Are similar inflammatory factors involved in strenuous exercise and sepsis? Intensive Care Med 1994; 20: 602-10.
5. Liesen H, Dufaus B, Hollmann W. Modification of serum glycoproteins on the days following prolonged physical exercise and the influence of physical training. Eur J Appl Physiol 1977; 37: 243-54
6. Armstrong RB. Initial events in exercise-induced muscular injury. Med Sci Sports Exercise 1990; 22: 429-35.
7. Ebbeling CB, Clarkson PM. Exercise-induced muscle damage and adaptation. Sports Med 1989; 7: 207-34.
8. Friden J, Sjostrom M, Ekblom B. Myofibrillar damage after intense eccentric exercise in man. Int J Sports Med 1983; 4: 170-6.
9. Hikida RS, Staron RS, Hagerman FC, Sherman WN, Costill DL. Muscle fiber necrosis associated with human marathon runners. J Neurol Sci 1983; 59: 185-203.
10. Jones DA, Newham DJ, Round JM, Tolfree SEJ. Experimental human muscle damage: morphological changes in relation to other indices of damage. J Physiol Lond 1986; 375: 435-48.
11. Dufaux B, Order U. Complement activation after prolonged exercise. Clin Chim Acta 1989; 179: 45-50.
12. Camus G, Duchateau J, Deby-Dupont G, Pincemail J, Deby C. Juchmès-Ferir A, Feron F, Lamy M. Anaphylatoxin C5a production during short-term submaximal dynamic exercise in man. Int J Sports Med 1994; 15: 32-5.
13. Dufaux B, Order U, Liesen L. Effect of a short maximal physical exercise on coagulation, fibrinolysis, and complement system, Int J Sports Med 1991; 12: S38-42.
14. Pincemail J, Camus G, Roesgen A, Dreezen E, Bertrand Y, Lismonde M, Deby-Dupont G, Deby C. Exercise induces pentane production and neutrophil activation in humans. Effects of propranolol. Eur J Appl Physiol 1990; 61: 319-22.
15. Sjödin B, Westing YH. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med 1990; 10: 236-54.
16. Northoff H, Berg A. Immunologic mediators as parameters of the reaction to strenuous exercise. Int J Sports Med 1991; 12: S9-15.
17. Pedersen BK. Influence of physical activity on the cellular immune system: mechanisms of action, Int J Sports Med 1991; 12: S23-9.
18. Pyne DB. Regulation of neutrophil function during exercise. Sports Med 1994; 17: 245-58.
19. Bosenberg AT, Brock-Utne JG, Gaffin SL, Wells MTB, Blacke GTW. Strenuous exercise causes systemic endotoxemia. J Appl Physiol 1988; 65: 106-8.
20. Brock-Utne JG, Gaffin SL, Wells MTB, Gathiram P, Sohar E, James MF, Morrell DF, Norman RJ, Bosenberg AT. Endotoxemia in exhausted runners after a long-distance race. S Afr Med J 1988; 73: 533-6.
21. Pincemail J, Deby-Dupont G, Deby C, Thirion A, Torpier G, Faymonville ME, Damas P, Tomassini M, Lamy M. Fast double antibody radioimmunoassay of human granulocyte myeloperoxidase and its application to human plasma. J Immunol Methods 1991; 137: 181-91.
22. Westphal O, Jann K. Bacterial lipopolysaccharides. Extraction with phenol-water and further applications of the procedure. In: Whistler RL, Wolfram ML, eds. Methods of carbohydrate chemistry, vol. V. New York: Academic Press, 1965: 83-87.
23. Galanos C, Lüderitz O, Westphal O. A new method for the extraction of R lipopolysaccharides. Eur J Biochem 1969; 9: 245-9.
24. Chang CM, Nowotny A. Relation of structures to function in bacterial O antigens. VII. Endotoxicity of lipid A. Immunochem 1975; 12: 19-28.
25. Nys M, Damas P, Damas F, Joassin L, Demonty J. A direct enzyme-linked immunosorbent assay (ELISA) for antibodies to enterobacterial Re core glycolipid and lipid A. Med Microbiol Immunol 1987; 176: 257-71.
26. Van Deventer SJH, Buller HR, Ten Cate JW, Sturk A, Pauw W. Endotoxaemia: an early predictor of septicaemia in febrile patients. Lancet 1988; 1: 605-9.
27. Moses FM. Gastrointestinal bleeding and the athlete. Am J Gastroenterology 1993; 88: 1157-59.
28. Brouns F, Beckers E. Is the gut an athletic organ? Sports Med 1993; 15: 242-57.
29. Halvorsen F-A, Ritland S. Gastrointestinal problems related to endurance event training. Sports Med 1992; 14: 157-63.
30. Moses F, Singh A, Smoak B, Hollander D, Deuster P. Alterations in intestinal permeability during prolonged high intensity running. Gastroenterology; 1991; 100: A472.
31. Morrison DC, Ryan JL. Endotoxins and disease mechanisms. Ann Rev Med 1987; 320: 365-76.
32. Mythen MG, Barclay GR, Purdy G, Hamilton-Davies C, Mackie U, Webb AR, Machin SJ. The role of endotoxin immunity, neutrophil degranulation and contact activation in the pathogenesis of post-operative organ dysfunction. Blood Coagulation Fibrinolysis 1993; 4: 999-1005.
33. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer, Dinarello CA, Cerami A, Wolf SM, Wilmore DW. Detection of circulating tumor necrosis after endotoxin administration. N Engl J Med 1988; 23: 1481-6.
34. Fong Y, Moldawer LL, Marano M, Wei H, Tatter SB, Clarick RH, Santhanam U, Sherris D, May LT, Seghal PB, Lowry SF. Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man. J Immunol 1989; 142: 2321-4.
35. Morrison DC, Kline LF Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS). J Immunol 1977; 118: 362-8.
36. Shalaby MR, Aggarwal BB, Rinderknecht E, Svedersky LP, Finkle BS, Palladino MAJR. Activation of human polymorphonuclear neutrophil function by tumor necrosis factor. J Immunol 1985; 135: 2069-73.
37. Klebanoff SJ, Vadas MA, Harla JM, Sparks LH, Gamble JR, Agosti JM, Waltersdorph AM. Stimulation of neutrophils by tumor necrosis factor. J Immunol 1986; 136: 4220-5.
38. Yancey KB. Biological properties of human C5a: Selected in vitro and in vivo studies. Clin Exp Immunol 1988; 71: 207-10.
39. Fujishima S, Aikawa N. Neutrophil-mediated tissue injury and its modulation. Int Care Med 1995; 21: 277-85.
40. Barclay GR. Endogenous endotoxin-core antibody (EndoCab) as a marker of endotoxin exposure and a prognostic indicator: a review. In: Levin J, Alving CR, Munford RS, Redl H, eds. Bacterial Endotoxins: Lipopolysaccharides from genes to therapy. New York: Wiley-Liss Inc, 1995; 263-72.
41. Jacob AI, Golberg PK, Bloom N, Degenshein GA, Kozinn PJ. Endotoxin and bacteria in the portal blood. Gastroenterology 1977; 72: 1268-70.
42. Barclay JR, Scott BB. Serological relationships between Escherichia coli and Salmonella smooth- and rough-mutant lipopolysaccharides as revealed by enzyme-linked immunosorbent assay for human immunoglobulin G antiendotoxin antibodies. Infect. Immun 1987; 55: 2706-14.
43. Nys M, Laub R, Damas P, Sondag D, Goethals T, Jamaer D, Joassin L, Lamy M. Screening and characterization of specific anti-lipopolysaccharide antibodies in Belgian blood donors by enzyme-linked immunosorbent assays. Eur J Clin Invest 1996; 26: 1134-42.