Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom

Biochemistry

Volumn 36, Issue 23, 1997, Pages 6936-6940

  Lu, Zhe ^a   MacKinnon, Roderick ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; POTASSIUM CHANNEL; SCORPION VENOM;

ARTICLE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SYNTHESIS; SCORPION; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SCORPION VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

LEIURUS QUINQUESTRIATUS; SCORPIONES; XENOPUS LAEVIS;

EID: 0030997658     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9702849     Document Type: Article

References (27)

1. Adams, M. E., and Swanson, G. (1994) TINS Suppl., 1-29.
2. Jan, L. Y., and Jan, Y. N. (1994) Nature 371, 119-122.
3. MacKinnon, R. (1991) Nature 350, 232-235
4. Liman, E. R., Tytgat, J., and Hess, P. (1992) Neuron 9, 861-871.
5. Yang, J., Jan, Y. N., and Jan, L. Y. (1995) Neuron 15, 1441-1447.
6. Ho, K., Nichols, C. G., Lederer, W. J., Lytton, J., Vassilev, P. M., Kanazirska, M. V., and Hebert, S. C. (1993) Nature 362, 31-38.
7. Kubo, Y., Baldwin, T. J., Jan, Y. N., and Jan, L. Y. (1993) Nature 362, 127-132.
8. Garcia, M. L., Garcia-Calvo, M., Hidalgo, P., Lee A., and MacKinnon, R. (1994) Biochemistry 33, 6834-6839.
9. Park, C.-S., Hausdorff, S. F., and Miller, C. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 2046-2050.
10. Escobar, L., Root, M. J., and MacKinnon, R. (1993) Biochemistry 32, 6982-6987.
11. Lu, Z., and MacKinnon, R. (1994) Nature 371, 243-246.
12. Wible, B. A., Taglialatela, M., Ficker, E., and Brown, A. M. (1994) Nature 371, 246-249.
13. Lucchesi, K., Ravindran, A., Young, H., and Moczydlowski, E. (1989) J. Membrane Biol. 109, 69-281.
14. Heginbotham, L., Lu, Z., Abramson, T., and MacKinnon, R. (1994) Biophys. J. 66, 1061-1067.
15. Schwalbe, R. A., Wang, Z., Wible, B. A., and Brown, A. M. (1995)J. Biol. Chem. 270, 15336-15340.
16. Park, C.-S., and Miller, C. (1992) Biochemistry 31, 7749-7755.
17. Stampe, P., Kolmakova-Partensky, L., and Miller, C. (1994) Biochemistry 33, 443-450.
18. Goldstein, S. A. N., Pheasant, D. J., and Miller, C. (1994) Neuron 12, 1377-1388.
19. Hidalgo, P., and MacKinnon, R. (1995) Science 268, 307-310.
20. Ranganathan, R., Lewis, J. H., and MacKinnon, R. (1996) Neuron 16, 131-139.
21. Aiyar, J., Withka, J. M., Rizzi, J. P., Singleton, D. H., Andrews, G. C., Lin, W., Boyd, J., Hanson, D. C., Simon, M., Dethlefs, B., Lee, C. L., Hall, J. E., Gutman, G. A., and Chandy, K. G. (1995) Neuron 15, 1169-1181.
22. Naranjo, D., and Miller, C. (1996) Neuron, 16, 123-130.
23. Heginbotham, L., Abramson, T., and MacKinnon, R. (1992) Science 258, 942-944.
24. MacKinnon, R., and Miller, C. (1988) J. Gen. Physiol. 91, 335-349.
25. Park, C.-S., and Miller, C. (1992b) Neuron 9, 307-313.
26. Goldstein, S. A. N., and Miller, C. (1993) Biophys. J. 65, 1613-1619.
27. Bontems, F., Gilquin, B., Roumestand, C., Menez, A., and Toma, F. (1992) Biochemistry 31, 7756-7764.