In vivo and in vitro evidence for nonrestricted transport of 2',7'- bis(2-carboxyethyl)-5(6)-carboxyfluorescein tetraacetoxymethyl ester at the blood-brain barrier

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 813-819

  Hirohashi, Tomoko ^a   Terasaki, Tetsuya ^a   Shigetoshi, Minoru ^a   Sugiyama, Yuichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2',7' BIS(2 CARBOXYETHYL) 5(6) CARBOXYFLUORESCEIN TETRAACETOXYMETHYL ESTER; DRUG METABOLITE; FLUORESCENT DYE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CATTLE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG TRANSPORT; DRUG UPTAKE; INTRAARTERIAL DRUG ADMINISTRATION; LIPOPHILICITY; MALE; MOLECULAR WEIGHT; NONHUMAN; PARTITION COEFFICIENT; PERMEABILITY; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

1-BUTANOL; 3-O-METHYLGLUCOSE; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BUTANOLS; CALORIMETRY; CAPILLARIES; CAROTID ARTERIES; CATTLE; CELLS, CULTURED; CEREBROVASCULAR CIRCULATION; DIFFUSION; ENDOTHELIUM, VASCULAR; FLUORESCEINS; INJECTIONS, INTRA-ARTERIAL; MALE; MANNITOL; RATS; RATS, WISTAR;

EID: 0030997276     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. ALLEN, C. N., HARPUR, E. S., GRAY, T. J., SIMMONS, N. L. AND HIRST, B. H.: Efflux of bis-carboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells. Biochem. Biophys. Res. Commun. 172: 262-267, 1990.
2. BANKS, W. A. AND KASTIN, A. J.: Peptides and the blood-brain barrier. Lipophilicity as a predictor of permeability. Brain Res. Bull. 15: 287-292, 1985.
3. BRADBURY, M.: The Concept of a Blood-Brain Barrier, John Wiley & Sons, New York, 1979.
4. CEFALU, W. T. AND PARDRIDGE, W. M.: Restrictive transport of a lipid-soluble peptide (cyclosporin) through the blood-brain barrier. J. Neurochem. 45: 1954-1956, 1985.
5. COLLINGTON, G. K., ALLEN, C. N., SIMMONS, N. L. AND HIRST, B. H.: Pharmacological profile of inhibition of 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein efflux in human H. C. T.-8 intestinal epithelial cells. Biochem. Pharmacol. 42: S33-38, 1991.
6. COLLINGTON, G. K., HUNTER, J., ALLEN, C. N., SIMMONS, N. L. A. N. D. HIRST, B. H.: Polarized efflux of 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers. Biochem. Pharmacol. 44: 417-424, 1992.
7. CORNFORD, E. M., BRAUN, L. D., OLDENDORF, W. H. AND HILL, M. A.: Comparision of lipid-mediated blood-brain-barrier penetrability in neonates and adults. Am. J. Physiol. 243: C161-168, 1982.
8. CORNFORD, E. M.: The blood-brain barrier, a dynamic regulatory interface. Mol. Physiol., 7: 219-260, 1985.
9. HUGHES, C. C. AND LANTOS, P. L.: Uptake of leucine and alanine by cultured cerebral capillary endothelial cells. Brain. Res. 480: 126-132, 1989.
10. LEO, A., HANSCH, C. AND ELKINS, D.: Partition coefficient and their uses. Chem. Rev. 71: 525-554, 1971.
11. LEVITAN, H., ZIYLAN, Z., SMITH, Q. R., TAKASATO, Y. AND RAPOPORT, S. I.: Brain uptake of a food dye, erythrosin B, prevented by plasma protein binding. Brain Res. 322: 131-134, 1984.
12. LEVIN, V. A.: Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23: 682-684, 1980.
13. LOWRY, O. H., ROSEBROUGH, N. J., FARR, A. L. AND RANDALL, R. J.: Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
14. MARTIN, A., SWARBRICK, J. AND CAMMARATA, A.: Physical Pharmacy, pp. 399-444, Lea & Febiger, Philadelphia, 1983.
15. OLDENDORF, W. H.: Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard. Brain. Res. 24: 372-376, 1970.
16. + exchange in gastric glands as measured with a cytoplasmic-trapped, fluorescent pH. indicator. Proc. Natl. Acad. Sci. U.S.A. 81: 7436-7440, 1984.
17. PARDRIDGE, W. M. AND FIERER, G.: Blood-brain barrier transport of butanol and water relative to N-isopropyl-p-iodoamphetamine as the internal reference. J. Cereb. Blood Flow Metab. 5: 275-281, 1985.
18. PARDRIDGE, W. M., LANDAW, E. M., MILLER, L. P., BRAWN, L. D. AND OLDENDORF, W. H.: Carotid artery injection technique: bounds for bolus mixing by plasma and by brain. J. Cereb. Blood Flow Metab. 5: 576-83, 1985.
19. PARDRIDGE, W. M.: Peptide Delivery to the Brain. Raven Press, New York, 1991.
20. PARDRIDGE, W. M.: Brain drug delivery and blood-brain barrier transport. Drug Delivery 1: 83-101, 1993.
21. PARDRIDGE, W. M.: New approaches to drug delivery through the blood-brain barrier. Trends Biotech, 12: 239-245, 1994.
22. SAHEKI, A., TERASAKI, T., TAMAI, I. AND TSUJI, A.: In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A. (H. M. G.-CoA) reductase inhibitors. Pharm. Res. 11: 305-311, 1994.
23. SCHINKEL, A. H., SMIT, J. J., VAN TELLINGEN, O., BEIJNEN, J. H., WAGENAAR, E., VAN DEEMTER, L., MOL, C. A. A. M., VAN DER VALK, M. A., ROBANUS-MAANDAG, E. C., T. E. RIELE, H. P. J., BERNS, A. J. M. AND BORST, P.: Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491-502, 1994.
24. TAKASATO, Y., RAPOPORT, S. I. AND SMITH, Q. R.: An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am. J. Physiol. 247: H484-493, 1984.
25. TAKEGUCHI, N., ICHIMURA, K., KOIKK, M., MATSUI, W., K.A.S.H. I.W.A.G.U.R.A., T. AND KAWAHARA, K.: Inhibition of the multidrug efflux pump in isolated hepatocyte couplets by immunosuppressants F. K.506 and cyclosporine. Transplantation 55: 646-650, 1993.
26. TATSUTA, T., NAITO, M., O. H.-HARA, T., SUGAWARA, I. AND TSURCO, T.: Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267: 20383-20391, 1992.
27. TERASAKI, T., TAKAKUWA, S., MORITANI, S. AND TSUJI, A.: Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells. J. Pharmacol. Exp. Ther. 258: 932-937, 1991.
28. TRAUBLE, H.: The movement of molecules across lipid membranes: a molecular theory. J. Membr. Biol. 4: 193-208, 1971.
29. TSUJI, A., KUBO, O., MIYAMOTO, E. AND YAMANA, T.: Physicochemical properties of β-lactam antibiotics: oil-water distribution. J. Pharm. Sci. 66: 1675-1679, 1977.
30. TSUJI, A., TERASAKI, T., TAKABATAKE, Y., TENDA, Y., TAMAI, I., YAMASHIMA, T., MORITANI, S., TSURUO, T. AND YAMASHITA, J.: P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51: 1427-1437, 1992.
31. TSUJI, A., TAMAI, I., SAKATA, A., TENDA, Y. AND TERASAKI, T.: Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem. Pharmacol. 46: 1096-1099, 1993.
32. VAN BREE, J. B. M. M., AUDUS, K. L. AND BORCHARDT, R. T.: Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary culture. Pharm. Res. 5: 369-371, 1988.
33. WEINER, I. D. AND HAMM, L. L.: Use of fluorescent dye BCECF to measure intracellular pH. in cortical collecting tubule. Am. J. Physiol. 256: F957-964, 1989.