Preclinical ocular irritation findings with dorzolamide hydrochloride

Journal of Toxicology - Cutaneous and Ocular Toxicology

Volumn 16, Issue 1, 1997, Pages 9-17

  Gordon, L R ^a   Bailly, Y ^b   Durand Cavagna, G ^b   Delort, P ^b   Peter, C P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Dohme Chibret Centre de Recherche Riom   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DORZOLAMIDE; GELRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CORNEA THICKNESS; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG FORMULATION; DRUG SAFETY; EYE IRRITATION; EYELID REFLEX; GLAUCOMA; LACRIMATION; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; SLIT LAMP; TOPICAL DRUG ADMINISTRATION;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0030997175     PISSN: 07313829     EISSN: None     Source Type: Journal    
DOI: 10.3109/15569529709048884     Document Type: Article

References (5)

1. D. L. Epstein and W. Grant, Carbonic anhydrase inhibitor side effects, Arch. Ophthalmol. 95: 1378-1382, 1977.
2. J. H. Draize, A. Woodard, and H. O. Calvery, Method for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes, J. Pharmacol. Exp. Ther. 82: 377-390, 1944.
3. J. W. Tukey, J. L. Ciminera, and J. F. Hayse, Testing the statistical certainty of a response to increasing doses of a drug, Biometrics 41: 295-301, 1985.
4. G. W. Snedecor and W. G. Cochran, Statistical Methods, 7th ed., Iowa State University Press, Ames, IA, 1980.
5. T. H. Maren, Carbonic anhydrase: chemistry, physiology and inhibition, Physiol. Rev. 47: 595-781, 1967.