Survival after a very low (< 5 x 106/l) CD4+ T-cell count in individuals infected with HIV

AIDS

Volumn 11, Issue 9, 1997, Pages 1123-1127

  Sabin, Caroline A ^a,b   Mocroft, Amanda ^a   Bofill, Margarita ^b   Janossy, George ^b   Johnson, Margaret ^b   Lee, Christine A ^a   Phillips, Andrew N ^a  

^a Diabetes and Nutritional Sciences Division   (United Kingdom)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Age; AIDS diagnosis; Antiretroviral therapy; CD8+ T cell count; Low CD4+ T cell count; Survival

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; COHORT ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; NONBIOLOGICAL MODEL; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SCHOOL CHILD; SURVIVAL; T LYMPHOCYTE; UNITED KINGDOM;

EID: 0030996987     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199709000-00007     Document Type: Article

References (27)

1. Montaner JSG, Lawson LM, Gervais A, et al.: Aerosol pentamidine for secondary prophylaxis of AIDS-related Pneumocystis carinii pneumonia. A randomised, placebo-controlled study. Ann Intern Med 1991, 114:948-953.
2. Cooper DA, Gatell JM, Kroon S, et al.: Zidovudine in persons with asymptomatic HIV infection and CD4+ cell counts greater than 400 per cubic millimeter. N Engl J Med 1993, 329:297-303.
3. Osmond D, Charlebois E, Lang W, Shiboski S, Moss A: Changes in AIDS survival time in two San Francisco cohorts of homosexual men, 1983 to 1993. JAMA 1994, 271:1083-1087.
4. Lundgren JD, Melbye M, Pedersen C, Rosenberg PS, Gerstoft J: Changing patterns of Kaposi's sarcoma in Danish acquired immunodeficiency syndrome patients with complete follow-up. Am J Epidemiol 1995, 141:652-658.
5. Apolonio EG, Hoover DR, He Y, et al.: Prognostic factors in human immunodeficiency virus-positive patients with a CD4+ lymphocyte count < 50/μl. J Infect Dis 1995, 171:829-836.
6. Yarchoan R, Venzon DJ, Pluda JM, et al.: CD4 count and the risk for death in patients infected with HIV receiving antiretroviral therapy. Ann Intern Med 1991, 115:184-189.
7. Colford JM Jr, Ngo L, Tager I: Factors associated with survival in human immunodeficiency virus-infected patients with very low CD4 counts. Am J Epidemiol 1994, 139:206-218.
8. Ehmann WC, Eyster ME, Wilson SE, Andes VVA, Goedert JJ: Relationship of CD4 lymphocyte counts to survival in a cohort of hemophiliacs infected with HIV. J Acquir Immune Defic Syndr 1494, 7:1095-1098.
9. Nightingale SD, Jockusch JD, Haslund I, Cal SX, Peterson DM, Loss SD: Logarithmic relationship of the CD4 count to survival in patients with human immunodeficiency virus infection. Arch Intern Med 1993, 153:1313-1318.
10. Bofill M, Janossy G, Lee CA, et al.: Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis. Clin Exp Immunol 1992, 88:243-252.
11. Sabin CA, Phillips AN, Lee CA, et al.: Beta-2 microglobulin as a predictor of prognosis in HIV-infected men with haemophila: a proposed strategy for use in clinical care. Br J Haematol 1994, 86:366-371.
12. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
13. Cox DR, Oakes D: Analysis of Survival Data. London: Chapman and Hall; 1984.
14. SAS Institute, Inc.: SAS/STAT User's Guide, Version 6, 4th Edn. Cary: SAS Institute, Inc.; 1992.
15. Hanson DL, Horsburgh CR Jr, Fann SA, Havlik JA, Thompson SE III: Survival prognosis of HIV-infected patients. J Acquir Immune Defic Syndr 1993, 6:624-629.
16. Lundgren JD, Pedersen C, Clumeck N, et al.: Survival differences in European patients with AIDS, 1979-1989. BMJ 1994, 308:1068-1073.
17. Anderson RE, Shiboski SC, Royce R, Jewell NP, Lang W, Winkelstein Jr W: CD8+ T lymphocytes and progression to AIDS in HIV-infected men: some observations. AIDS 1991, 5:213-215.
18. Chevret S, Roquin H, Ganne P, Lefrère J-J: Prognostic value of an elevated CD8 lymphocyte count in HIV infection. Results of a prospective study of 152 asymptomatic HIV-positive individuals. AIDS 1992, 6:1349-1352.
19. Phillips AN, Sabin CA, Elford J, Bofill M, Lee CA, Janossy G: CD8 lymphocyte counts and serum immunoglobulin A levels early in HIV infection as predictors of CD4 lymphocyte depletion during 8 years of follow-up. AIDS 1993, 7:975-980.
20. Schlumpberger JM, Wolde-Tsadik G, Yao JFF, Hara J: CD8+ lymphocyte counts and the risk of death in advanced HIV infection. J Fam Pract 1994, 38:33-38.
21. Brinchmann JE, Vartdal F, Thorsby E: T lymphocyte subset changes in human immunodeficiency virus infection. J Acquir Immune Defic Syndr 1989, 2:398-403.
22. Nishanian P, Hofmann B, Wang Y, Jackson AL, Detels R, Fahey JL: Serum soluble CD8 molecule is a marker of CD8 T-cell activation in HIV-1 disease. AIDS 1491, 5:805-812.
23. Mackewicz CE, Blackbourn DJ, Levy JA: CD8+ T cells suppress human immunodeficiency virus replication by inhibiting viral transcription. Proc Natl Acad Sci USA 1995, 92:2308-2312.
24. Henrard DR, Phillips IF, Muenz LR, et al.: Natural history of HIV-1 cell-free viremia. JAMA 1995, 274:554-558.
25. Havlir DV, Richman DD: Viral dynamics of HIV: Implications for drug development and therapeutic strategies. Ann Intern Med 1996, 124:984-994.
26. Popescu M, Wolf E, Jaegel-Guedes E, Jaeger H: HIV-1 RNA viral load measurements. Are they a good predictor of mortality in CDC-AIDS-patients? XI International Conference on AIDS. Vancouver, July 1996 [ThB4298].
27. Hughes MD, Stein DS, Gundacker HM, Valentine FT, Phair JP, Volberding PA: Within-subject variation in CD4 lymphocyte count in asymptomatic human immunodeficiency virus infection: implications for patient monitoring. J Infect Dis 1994, 169:28-36.